Reviewed, UniProtKB/Swiss-Prot O42123 (FKB1A_XENLA)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1A
      Short name=PPIase FKBP1A
    EC=5.2.1.8
Alternative name(s):
    FK506-binding protein 1A
      Short name=FKBP-1A
    Rotamase
    Immunophilin FKBP12
      Short name=12 kDa FKBP
      Short name=FKBP-12

Gene names

Name:

fkbp1a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase Rotamase
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 108	107	Peptidyl-prolyl cis-trans isomerase FKBP1A		PRO_0000075293
Regions
	Domain	20 – 108	89	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	O42123-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: CFA335430638BC08	FASTA	108	11,912
	10 20 30 40 50 60 MGVQVETITE GDGRTFPKKG QTVVVHYVGS LENGKKFDSS RDRNKPFKFI IGRCEVIRGW 70 80 90 100 EEGVAQMSVG QRARLTCSPD FAYGATGHPG IIPPNATLTF DVELLRLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Xenopus FK 506-binding protein homolog induces a secondary axis in frog embryos, which is inhibited by coexisting BMP 4 signaling." Nishinakmaura R., Matsumoto Y., Uochi T., Asashima M., Yokota T. Biochem. Biophys. Res. Commun. 239:585-591(1997) [PubMed: 9344875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB006678 mRNA. Translation: BAA23102.1. BC041248 mRNA. Translation: AAH41248.1.
PIR	JC5764.
RefSeq	NP_001079382.1.
UniGene	Xl.960
3D structure databases
HSSP	HSSP built from PDB template 1FKL based on UniProtKB P18203.
SMR	O42123. Positions 2-108.
ModBase	Search...
Genome annotation databases
GeneID	379069.
KEGG	xla:379069.
Organism-specific databases
Xenbase	XB-FEAT-5836757.
Phylogenomic databases
HOVERGEN	O42123.
Enzyme and pathway databases
BRENDA	5.2.1.8. 648.
Family and domain databases
InterPro	IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKB1A_XENLA

Accession

Primary (citable) accession number: O42123
Secondary accession number(s): Q5D0D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project