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O42122

- WNT5B_ORYLA

UniProt

O42122 - WNT5B_ORYLA

Protein

Protein Wnt-5b

Gene

wnt5b

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5b
    Gene namesi
    Name:wnt5b
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Chromosome 23

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 371343Protein Wnt-5bPRO_0000041436Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi95 ↔ 106By similarity
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 153By similarity
    Disulfide bondi155 ↔ 173By similarity
    Disulfide bondi229 ↔ 243By similarity
    Disulfide bondi231 ↔ 238By similarity
    Lipidationi235 – 2351O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi316 ↔ 331By similarity
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi346 ↔ 361By similarity
    Disulfide bondi348 ↔ 358By similarity
    Disulfide bondi353 ↔ 354By similarity

    Post-translational modificationi

    Palmitoylation at Ser-235 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi8090.ENSORLP00000017197.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115016.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiO42122.
    KOiK00444.
    OMAiQGQRKLC.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O42122-1 [UniParc]FASTAAdd to Basket

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    MDNRSVQRRR TGDVRHLLLA AAFLTCNSQL LLVDANSWWS LGLTPIQRPE    50
    MYIIGAQPLC SQLSGLSQGQ RKLCQLYQDH MTYIGDGAKT GIKECQYQFR 100
    QRRWNCSTVD NTSVFGRVMQ IGSRETAFTY AISAAGVVNA ISRACREGEL 150
    STCGCSRTAR PRDLPRDWLW GGCGDNVYYG KRFAQEFVDA REREKNYPRG 200
    SREHARTLMN LHNNEAGRQA VYNLADVACK CHGVSGSCSL KTCWLQLADF 250
    RRVGEFLKEK YDSAAAMRIG RKGRLELLDK RFNPPTPEDL VYIDLSPDYC 300
    HRNETTGSLG TQGRFCNKTS EGMDGCELMC CGRGYDQFRV YKHERCHCKF 350
    HWCCYVKCKR CSTLVDQFVC K 371
    Length:371
    Mass (Da):42,280
    Last modified:January 1, 1998 - v1
    Checksum:iE9864E1FA342E82D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006579 mRNA. Translation: BAA22143.1.
    RefSeqiNP_001098129.1. NM_001104659.1.
    UniGeneiOla.60.

    Genome annotation databases

    EnsembliENSORLT00000017198; ENSORLP00000017197; ENSORLG00000013709.
    GeneIDi100049184.
    KEGGiola:100049184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006579 mRNA. Translation: BAA22143.1 .
    RefSeqi NP_001098129.1. NM_001104659.1.
    UniGenei Ola.60.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8090.ENSORLP00000017197.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSORLT00000017198 ; ENSORLP00000017197 ; ENSORLG00000013709 .
    GeneIDi 100049184.
    KEGGi ola:100049184.

    Organism-specific databases

    CTDi 81029.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115016.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi O42122.
    KOi K00444.
    OMAi QGQRKLC.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yokoi H., Nishimatsu A., Ozato K., Yoda K.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiWNT5B_ORYLA
    AccessioniPrimary (citable) accession number: O42122
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3