Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O42122 (WNT5B_ORYLA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-235 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-95. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 371343Protein Wnt-5b
PRO_0000041436

Amino acid modifications

Lipidation951S-palmitoyl cysteine By similarity
Lipidation2351O-palmitoyl serine; by PORCN By similarity
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O42122 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: E9864E1FA342E82D

FASTA37142,280
        10         20         30         40         50         60 
MDNRSVQRRR TGDVRHLLLA AAFLTCNSQL LLVDANSWWS LGLTPIQRPE MYIIGAQPLC 

        70         80         90        100        110        120 
SQLSGLSQGQ RKLCQLYQDH MTYIGDGAKT GIKECQYQFR QRRWNCSTVD NTSVFGRVMQ 

       130        140        150        160        170        180 
IGSRETAFTY AISAAGVVNA ISRACREGEL STCGCSRTAR PRDLPRDWLW GGCGDNVYYG 

       190        200        210        220        230        240 
KRFAQEFVDA REREKNYPRG SREHARTLMN LHNNEAGRQA VYNLADVACK CHGVSGSCSL 

       250        260        270        280        290        300 
KTCWLQLADF RRVGEFLKEK YDSAAAMRIG RKGRLELLDK RFNPPTPEDL VYIDLSPDYC 

       310        320        330        340        350        360 
HRNETTGSLG TQGRFCNKTS EGMDGCELMC CGRGYDQFRV YKHERCHCKF HWCCYVKCKR 

       370 
CSTLVDQFVC K 

« Hide

References

[1]Yokoi H., Nishimatsu A., Ozato K., Yoda K.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006579 mRNA. Translation: BAA22143.1.
RefSeqNP_001098129.1. NM_001104659.1.
UniGeneOla.60.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8090.ENSORLP00000017197.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSORLT00000017198; ENSORLP00000017197; ENSORLG00000013709.
GeneID100049184.
KEGGola:100049184.

Organism-specific databases

CTD81029.

Phylogenomic databases

eggNOGNOG284879.
GeneTreeENSGT00740000115016.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidO42122.
KOK00444.
OMAQGQRKLC.
OrthoDBEOG7C8GJ8.
TreeFamTF105310.

Family and domain databases

InterProIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF23. PTHR12027:SF23. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWNT5B_ORYLA
AccessionPrimary (citable) accession number: O42122
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families