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Protein

Protein Wnt-5b

Gene

wnt5b

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:wnt5b
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 371343Protein Wnt-5bPRO_0000041436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 106By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi145 ↔ 153By similarity
Disulfide bondi155 ↔ 173By similarity
Disulfide bondi229 ↔ 243By similarity
Disulfide bondi231 ↔ 238By similarity
Lipidationi235 – 2351O-palmitoleyl serine; by PORCNBy similarity
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi316 ↔ 331By similarity
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi346 ↔ 361By similarity
Disulfide bondi348 ↔ 358By similarity
Disulfide bondi353 ↔ 354By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017197.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO42122.
KOiK00444.
OMAiQGQRKLC.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRSVQRRR TGDVRHLLLA AAFLTCNSQL LLVDANSWWS LGLTPIQRPE
60 70 80 90 100
MYIIGAQPLC SQLSGLSQGQ RKLCQLYQDH MTYIGDGAKT GIKECQYQFR
110 120 130 140 150
QRRWNCSTVD NTSVFGRVMQ IGSRETAFTY AISAAGVVNA ISRACREGEL
160 170 180 190 200
STCGCSRTAR PRDLPRDWLW GGCGDNVYYG KRFAQEFVDA REREKNYPRG
210 220 230 240 250
SREHARTLMN LHNNEAGRQA VYNLADVACK CHGVSGSCSL KTCWLQLADF
260 270 280 290 300
RRVGEFLKEK YDSAAAMRIG RKGRLELLDK RFNPPTPEDL VYIDLSPDYC
310 320 330 340 350
HRNETTGSLG TQGRFCNKTS EGMDGCELMC CGRGYDQFRV YKHERCHCKF
360 370
HWCCYVKCKR CSTLVDQFVC K
Length:371
Mass (Da):42,280
Last modified:January 1, 1998 - v1
Checksum:iE9864E1FA342E82D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006579 mRNA. Translation: BAA22143.1.
RefSeqiNP_001098129.1. NM_001104659.1.
XP_011489304.1. XM_011491002.1.
UniGeneiOla.60.

Genome annotation databases

EnsembliENSORLT00000017198; ENSORLP00000017197; ENSORLG00000013709.
GeneIDi100049184.
KEGGiola:100049184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006579 mRNA. Translation: BAA22143.1.
RefSeqiNP_001098129.1. NM_001104659.1.
XP_011489304.1. XM_011491002.1.
UniGeneiOla.60.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSORLT00000017198; ENSORLP00000017197; ENSORLG00000013709.
GeneIDi100049184.
KEGGiola:100049184.

Organism-specific databases

CTDi81029.

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO42122.
KOiK00444.
OMAiQGQRKLC.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Yokoi H., Nishimatsu A., Ozato K., Yoda K.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiWNT5B_ORYLA
AccessioniPrimary (citable) accession number: O42122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 22, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.