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Protein

Protein Wnt-5b

Gene

wnt5b

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:wnt5b
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000004143629 – 371Protein Wnt-5bAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 106By similarity
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 153By similarity
Disulfide bondi155 ↔ 173By similarity
Disulfide bondi229 ↔ 243By similarity
Disulfide bondi231 ↔ 238By similarity
Lipidationi235O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi316 ↔ 331By similarity
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 361By similarity
Disulfide bondi348 ↔ 358By similarity
Disulfide bondi353 ↔ 354By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017197

Structurei

3D structure databases

SMRiO42122
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO42122
KOiK00444
OMAiFRRVGEF
OrthoDBiEOG091G0OFF
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026537 Wnt5b
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF87 PTHR12027:SF87, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRSVQRRR TGDVRHLLLA AAFLTCNSQL LLVDANSWWS LGLTPIQRPE
60 70 80 90 100
MYIIGAQPLC SQLSGLSQGQ RKLCQLYQDH MTYIGDGAKT GIKECQYQFR
110 120 130 140 150
QRRWNCSTVD NTSVFGRVMQ IGSRETAFTY AISAAGVVNA ISRACREGEL
160 170 180 190 200
STCGCSRTAR PRDLPRDWLW GGCGDNVYYG KRFAQEFVDA REREKNYPRG
210 220 230 240 250
SREHARTLMN LHNNEAGRQA VYNLADVACK CHGVSGSCSL KTCWLQLADF
260 270 280 290 300
RRVGEFLKEK YDSAAAMRIG RKGRLELLDK RFNPPTPEDL VYIDLSPDYC
310 320 330 340 350
HRNETTGSLG TQGRFCNKTS EGMDGCELMC CGRGYDQFRV YKHERCHCKF
360 370
HWCCYVKCKR CSTLVDQFVC K
Length:371
Mass (Da):42,280
Last modified:January 1, 1998 - v1
Checksum:iE9864E1FA342E82D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006579 mRNA Translation: BAA22143.1
RefSeqiNP_001098129.1, NM_001104659.1
XP_011489304.1, XM_011491002.1
UniGeneiOla.60

Genome annotation databases

EnsembliENSORLT00000017198; ENSORLP00000017197; ENSORLG00000013709
GeneIDi100049184
KEGGiola:100049184

Similar proteinsi

Entry informationi

Entry nameiWNT5B_ORYLA
AccessioniPrimary (citable) accession number: O42122
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health