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O42122

- WNT5B_ORYLA

UniProt

O42122 - WNT5B_ORYLA

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Protein
Protein Wnt-5b
Gene
wnt5b
Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:wnt5b
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038: Chromosome 23

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 371343Protein Wnt-5b
PRO_0000041436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 106 By similarity
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi145 ↔ 153 By similarity
Disulfide bondi155 ↔ 173 By similarity
Disulfide bondi229 ↔ 243 By similarity
Disulfide bondi231 ↔ 238 By similarity
Lipidationi235 – 2351O-palmitoyl serine; by PORCN By similarity
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi316 ↔ 331 By similarity
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi346 ↔ 361 By similarity
Disulfide bondi348 ↔ 358 By similarity
Disulfide bondi353 ↔ 354 By similarity

Post-translational modificationi

Palmitoylation at Ser-235 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017197.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00740000115016.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO42122.
KOiK00444.
OMAiQGQRKLC.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O42122-1 [UniParc]FASTAAdd to Basket

« Hide

MDNRSVQRRR TGDVRHLLLA AAFLTCNSQL LLVDANSWWS LGLTPIQRPE    50
MYIIGAQPLC SQLSGLSQGQ RKLCQLYQDH MTYIGDGAKT GIKECQYQFR 100
QRRWNCSTVD NTSVFGRVMQ IGSRETAFTY AISAAGVVNA ISRACREGEL 150
STCGCSRTAR PRDLPRDWLW GGCGDNVYYG KRFAQEFVDA REREKNYPRG 200
SREHARTLMN LHNNEAGRQA VYNLADVACK CHGVSGSCSL KTCWLQLADF 250
RRVGEFLKEK YDSAAAMRIG RKGRLELLDK RFNPPTPEDL VYIDLSPDYC 300
HRNETTGSLG TQGRFCNKTS EGMDGCELMC CGRGYDQFRV YKHERCHCKF 350
HWCCYVKCKR CSTLVDQFVC K 371
Length:371
Mass (Da):42,280
Last modified:January 1, 1998 - v1
Checksum:iE9864E1FA342E82D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006579 mRNA. Translation: BAA22143.1.
RefSeqiNP_001098129.1. NM_001104659.1.
UniGeneiOla.60.

Genome annotation databases

EnsembliENSORLT00000017198; ENSORLP00000017197; ENSORLG00000013709.
GeneIDi100049184.
KEGGiola:100049184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006579 mRNA. Translation: BAA22143.1 .
RefSeqi NP_001098129.1. NM_001104659.1.
UniGenei Ola.60.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8090.ENSORLP00000017197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSORLT00000017198 ; ENSORLP00000017197 ; ENSORLG00000013709 .
GeneIDi 100049184.
KEGGi ola:100049184.

Organism-specific databases

CTDi 81029.

Phylogenomic databases

eggNOGi NOG284879.
GeneTreei ENSGT00740000115016.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi O42122.
KOi K00444.
OMAi QGQRKLC.
OrthoDBi EOG7C8GJ8.
TreeFami TF105310.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Yokoi H., Nishimatsu A., Ozato K., Yoda K.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiWNT5B_ORYLA
AccessioniPrimary (citable) accession number: O42122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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