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Protein

Aristaless-related homeobox protein

Gene

arx

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi215 – 27460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • neuron development Source: ZFIN
  • pancreatic A cell development Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • subthalamus development Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aristaless-related homeobox protein
Short name:
ARX
Gene namesi
Name:arx
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-990415-15. arxa.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Aristaless-related homeobox proteinPRO_0000048818Add
BLAST

Proteomic databases

PaxDbiO42115.
PRIDEiO42115.

Expressioni

Tissue specificityi

Expressed in brain.

Developmental stagei

Expressed at 10 hours and 12 hours in presumptive diencephalon. Expressed transiently at 12 hours in caudal telencephalon. Later expression in floor plate and somites, followed by rostral telencephalon and ventral thalamus. Expressed at 40 hours in hypothalamus.

Gene expression databases

BgeeiENSDARG00000058011.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000075256.

Structurei

3D structure databases

ProteinModelPortaliO42115.
SMRiO42115. Positions 214-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi421 – 43414OARPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi320 – 3278Poly-Ala
Compositional biasi409 – 4135Poly-Ser

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000012381.
HOVERGENiHBG004285.
InParanoidiO42115.
KOiK09452.
OMAiIGPTFGR.
OrthoDBiEOG091G0S4E.
PhylomeDBiO42115.
TreeFamiTF350743.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQYDDDSR DRSECKSKSP TVLSSYCIDS ILGRRSPCKV RQLGAQSLPA
60 70 80 90 100
PVRPDHEMTT EVTSKENSFD SDMHLPPKLR RLYGPGGKYL DSGRGFHEHL
110 120 130 140 150
EKGERERLLD QACESLKISQ APQVSISRSK SYRENAPFSQ SDEGQSPEHM
160 170 180 190 200
AQELVELSTL KFEEDVVKEE ACGDNSLSPK DEESLHNDGD VKDGEDSVCL
210 220 230 240 250
SAGSDSEEGM LKRKQRRYRT TFTSYQLEEL ERAFQKTHYP DVFTREELAM
260 270 280 290 300
RLDLTEARVQ VWFQNRRAKW RKREKAGVQA HPTGLPFPGP LAAAHPLSHY
310 320 330 340 350
LEGGPFPPHP HPALESAWTA AAAAAAAFPG LAPPPNSSAL PPATPLGLGT
360 370 380 390 400
FLGTAMFRHP AFIGPTFGRL FSSMGPLTSA STAAALLRQT APPVESPVQP
410 420 430 440 450
SAALPEPPSS SSSTAADRRA SSIAALRLKA KEHSAQLTQL NILPSGTAGK

EVC
Length:453
Mass (Da):49,396
Last modified:January 1, 1998 - v1
Checksum:i547F7CC478534808
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006104 mRNA. Translation: BAA21764.1.
RefSeqiNP_571459.1. NM_131384.1.
UniGeneiDr.9011.

Genome annotation databases

EnsembliENSDART00000080810; ENSDARP00000075256; ENSDARG00000058011.
GeneIDi30657.
KEGGidre:30657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006104 mRNA. Translation: BAA21764.1.
RefSeqiNP_571459.1. NM_131384.1.
UniGeneiDr.9011.

3D structure databases

ProteinModelPortaliO42115.
SMRiO42115. Positions 214-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000075256.

Proteomic databases

PaxDbiO42115.
PRIDEiO42115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000080810; ENSDARP00000075256; ENSDARG00000058011.
GeneIDi30657.
KEGGidre:30657.

Organism-specific databases

CTDi30657.
ZFINiZDB-GENE-990415-15. arxa.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000012381.
HOVERGENiHBG004285.
InParanoidiO42115.
KOiK09452.
OMAiIGPTFGR.
OrthoDBiEOG091G0S4E.
PhylomeDBiO42115.
TreeFamiTF350743.

Miscellaneous databases

PROiO42115.

Gene expression databases

BgeeiENSDARG00000058011.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARX_DANRE
AccessioniPrimary (citable) accession number: O42115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.