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Protein

Hepatocyte nuclear factor 3-beta

Gene

foxa2

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription activator for a number of liver genes. Interacts with the cis-acting regulatory regions of these genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi150 – 24495Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-beta
Short name:
HNF-3-beta
Short name:
HNF-3B
Alternative name(s):
Forkhead box protein A2
Me-HNF3B
Gene namesi
Name:foxa2
Synonyms:hnf3b
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Hepatocyte nuclear factor 3-betaPRO_0000091798Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000021768.

Structurei

3D structure databases

ProteinModelPortaliO42097.
SMRiO42097. Positions 150-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 12493Met-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3563. Eukaryota.
COG5025. LUCA.
HOVERGENiHBG006621.
InParanoidiO42097.
KOiK08035.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR013638. Fork-head_N.
IPR001766. Fork_head_dom.
IPR018533. Forkhead_box_C.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF08430. Forkhead_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O42097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLGAVKMEG HEHTDWSTYY GEPECYTSVG NMNTGLGMNS MNTYMSMSGM
60 70 80 90 100
STTANMTANS MNMSYVNTGM SPSMTGMSPG TGAMNGMGAG MTAMSTALSP
110 120 130 140 150
SMSPMTGQPG SMNALTSYTN MNAMSPIYGQ SNINRSRDPK TYRRSYTHAK
160 170 180 190 200
PPYSYISLIT MAIQQSPSKM LTLAEIYQWI MDLFPFYRQN QQRWQNSIRH
210 220 230 240 250
SLSFNDCFLK VPRSPDKPGK GSFWTLHPDS GNMFENGCYL RRQKRFKCEK
260 270 280 290 300
KMSMKEPGRK GGDGGSANSS SDSCNGNESP HSNSSSGEHK RSLSDMKGSQ
310 320 330 340 350
ALSPEHTAPS PVSQGQHLMS QHHSVLAHEA HLKPEHHYSF NHPFSINNLM
360 370 380 390 400
SSEQQHHKMD LKTYEQVMHY SGYGSPMTGA LSMGSMAGKA GLDSASIPDT
410
SYYQGVYSRP IMNSS
Length:415
Mass (Da):45,722
Last modified:January 1, 1998 - v1
Checksum:iCB85A0C2A20FF52A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001572 mRNA. Translation: BAA23579.1.
RefSeqiNP_001098162.1. NM_001104692.1.
UniGeneiOla.93.

Genome annotation databases

GeneIDi100049256.
KEGGiola:100049256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001572 mRNA. Translation: BAA23579.1.
RefSeqiNP_001098162.1. NM_001104692.1.
UniGeneiOla.93.

3D structure databases

ProteinModelPortaliO42097.
SMRiO42097. Positions 150-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000021768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100049256.
KEGGiola:100049256.

Organism-specific databases

CTDi3170.

Phylogenomic databases

eggNOGiKOG3563. Eukaryota.
COG5025. LUCA.
HOVERGENiHBG006621.
InParanoidiO42097.
KOiK08035.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR013638. Fork-head_N.
IPR001766. Fork_head_dom.
IPR018533. Forkhead_box_C.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF08430. Forkhead_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXA2_ORYLA
AccessioniPrimary (citable) accession number: O42097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.