ID   TY3H_ANGAN              Reviewed;         488 AA.
AC   O42091;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Tyrosine 3-monooxygenase;
DE            EC=1.14.16.2;
DE   AltName: Full=Tyrosine 3-hydroxylase;
DE            Short=TH;
GN   Name=th;
OS   Anguilla anguilla (European freshwater eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7936;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=98344760; PubMed=9681435;
RA   Boularand S., Biguet N.F., Vidal B., Veron M., Mallet J.,
RA   Vincent J.D., Dufour S., Vernier P.;
RT   "Tyrosine hydroxylase in the European eel (Anguilla anguilla): cDNA
RT   cloning, brain distribution, and phylogenetic analysis.";
RL   J. Neurochem. 71:460-470(1998).
CC   -!- FUNCTION: Plays an important role in the physiology of adrenergic
CC       neurons (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-
CC       dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.
CC   -!- COFACTOR: Fe(2+) ion.
CC   -!- ENZYME REGULATION: Phosphorylation leads to an increase in the
CC       catalytic activity (By similarity).
CC   -!- PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis;
CC       dopamine from L-tyrosine: step 1/2.
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family.
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DR   EMBL; AJ000731; CAA04264.1; -; mRNA.
DR   HSSP; P04177; 1TOH.
DR   SMR; O42091; 150-488.
DR   HOVERGEN; O42091; -.
DR   BRENDA; 1.14.16.2; 273635.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:EC.
DR   GO; GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
DR   GO; GO:0042423; P:catecholamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   InterPro; IPR005962; Tyr_3_mOase.
DR   InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR   Gene3D; G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
DR   PANTHER; PTHR11473; Aaa_hydroxylase; 1.
DR   Pfam; PF00351; Biopterin_H; 1.
DR   PIRSF; PIRSF000336; TH; 1.
DR   PRINTS; PR00372; FYWHYDRXLASE.
DR   ProDom; PD002559; Aaa_hydroxylase; 1.
DR   TIGRFAMs; TIGR01269; Tyr_3_monoox; 1.
DR   PROSITE; PS00367; BIOPTERIN_HYDROXYL; 1.
PE   2: Evidence at transcript level;
KW   Catecholamine biosynthesis; Iron; Metal-binding; Monooxygenase;
KW   Neurotransmitter biosynthesis; Oxidoreductase; Phosphoprotein.
FT   CHAIN         1    488       Tyrosine 3-monooxygenase.
FT                                /FTId=PRO_0000205559.
FT   METAL       321    321       Iron (By similarity).
FT   METAL       326    326       Iron (By similarity).
FT   METAL       366    366       Iron (By similarity).
FT   MOD_RES      38     38       Phosphoserine; by PKA (By similarity).
SQ   SEQUENCE   488 AA;  55490 MW;  573553BA39EBD448 CRC64;
     MPISNSSGSS TKSITRAGSE LDRADSITSP RFVGRRQSLI EDARKEREAA AAAESSEASE
     QIVFDEEDGK ALLNLFFTLR SSKIPALSRA LKVFETFEAK IHHLETRTRR KPKDSLEDLE
     YFVRCEVHLA DVSTLISSIR RIAEDVRTTK EVKFHWFPKK ISELDSCHHL VTKFDPDLDQ
     DHPGFTDPVY RQRRRMIGEI AFRYKHGEPI PRVEYTEEEI GTWREVYSTL RDLYTTHACS
     EHLEAFRLLE RHCGYSPNSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ
     CTQYIRHASS PMHSPEPDCV HELLGHVPML ADRTFAQFSQ NIGLASLGAS EEDIEKLSTL
     YWFTVEFGLC KQGDGVKAYG AGLLSSYGEL VHSLSDEPER REFDPEAAAA EPYQDQNYQS
     VYFVSESFTD AKEKLRVYAA GINRPFSVRF DPYTYSIEVL DNPLKIRGGL ESVKDELKVL
     TDALNVLA
//