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O42091 (TY3H_ANGAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine 3-monooxygenase

EC=1.14.16.2
Alternative name(s):
Tyrosine 3-hydroxylase
Short name=TH
Gene names
Name:th
OrganismAnguilla anguilla (European freshwater eel) (Muraena anguilla)
Taxonomic identifier7936 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an important role in the physiology of adrenergic neurons By similarity.

Catalytic activity

L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.

Cofactor

Fe2+ ion.

Enzyme regulation

Phosphorylation leads to an increase in the catalytic activity By similarity.

Pathway

Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Tyrosine 3-monooxygenase
PRO_0000205559

Sites

Metal binding3211Iron By similarity
Metal binding3261Iron By similarity
Metal binding3661Iron By similarity

Amino acid modifications

Modified residue381Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
O42091 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 573553BA39EBD448

FASTA48855,490
        10         20         30         40         50         60 
MPISNSSGSS TKSITRAGSE LDRADSITSP RFVGRRQSLI EDARKEREAA AAAESSEASE 

        70         80         90        100        110        120 
QIVFDEEDGK ALLNLFFTLR SSKIPALSRA LKVFETFEAK IHHLETRTRR KPKDSLEDLE 

       130        140        150        160        170        180 
YFVRCEVHLA DVSTLISSIR RIAEDVRTTK EVKFHWFPKK ISELDSCHHL VTKFDPDLDQ 

       190        200        210        220        230        240 
DHPGFTDPVY RQRRRMIGEI AFRYKHGEPI PRVEYTEEEI GTWREVYSTL RDLYTTHACS 

       250        260        270        280        290        300 
EHLEAFRLLE RHCGYSPNSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ 

       310        320        330        340        350        360 
CTQYIRHASS PMHSPEPDCV HELLGHVPML ADRTFAQFSQ NIGLASLGAS EEDIEKLSTL 

       370        380        390        400        410        420 
YWFTVEFGLC KQGDGVKAYG AGLLSSYGEL VHSLSDEPER REFDPEAAAA EPYQDQNYQS 

       430        440        450        460        470        480 
VYFVSESFTD AKEKLRVYAA GINRPFSVRF DPYTYSIEVL DNPLKIRGGL ESVKDELKVL 


TDALNVLA 

« Hide

References

[1]"Tyrosine hydroxylase in the European eel (Anguilla anguilla): cDNA cloning, brain distribution, and phylogenetic analysis."
Boularand S., Biguet N.F., Vidal B., Veron M., Mallet J., Vincent J.D., Dufour S., Vernier P.
J. Neurochem. 71:460-470(1998) [PubMed: 9681435] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ000731 mRNA. Translation: CAA04264.1.

3D structure databases

ProteinModelPortalO42091.
SMRO42091. Positions 150-488.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006841.

Family and domain databases

InterProIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view]
Gene3DG3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHERPTHR11473. Aaa_hydroxylase. 1 hit.
PfamPF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 1 hit.
[Graphical view]
PIRSFPIRSF000336. TH. 1 hit.
PRINTSPR00372. FYWHYDRXLASE.
SUPFAMSSF56534. Aaa_hydroxylase. 1 hit.
TIGRFAMsTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTY3H_ANGAN
AccessionPrimary (citable) accession number: O42091
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 28, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families