O42091 (TY3H_ANGAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine 3-monooxygenase
EC=1.14.16.2

Alternative name(s):
Tyrosine 3-hydroxylase
Short name=TH

Gene names

Name:

th

Organism

Anguilla anguilla (European freshwater eel) (Muraena anguilla)

Taxonomic identifier

7936 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Anguilliformes › Anguillidae › Anguilla

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the physiology of adrenergic neurons By similarity.
Catalytic activity	L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.
Cofactor	Fe2+ ion.
Enzyme regulation	Phosphorylation leads to an increase in the catalytic activity By similarity.
Pathway	Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
Sequence similarities	Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Ontologies

Keywords
Biological process	Catecholamine biosynthesis Neurotransmitter biosynthesis
Ligand	Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro catecholamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW neurotransmitter biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro tyrosine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Tyrosine 3-monooxygenase		PRO_0000205559
Sites
	Metal binding	321	1	Iron By similarity
	Metal binding	326	1	Iron By similarity
	Metal binding	366	1	Iron By similarity
Amino acid modifications
	Modified residue	38	1	Phosphoserine; by PKA By similarity

Sequences

	Sequence		Length	Mass (Da)
	O42091 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 573553BA39EBD448	FASTA	488	55,490
	10 20 30 40 50 60 MPISNSSGSS TKSITRAGSE LDRADSITSP RFVGRRQSLI EDARKEREAA AAAESSEASE 70 80 90 100 110 120 QIVFDEEDGK ALLNLFFTLR SSKIPALSRA LKVFETFEAK IHHLETRTRR KPKDSLEDLE 130 140 150 160 170 180 YFVRCEVHLA DVSTLISSIR RIAEDVRTTK EVKFHWFPKK ISELDSCHHL VTKFDPDLDQ 190 200 210 220 230 240 DHPGFTDPVY RQRRRMIGEI AFRYKHGEPI PRVEYTEEEI GTWREVYSTL RDLYTTHACS 250 260 270 280 290 300 EHLEAFRLLE RHCGYSPNSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ 310 320 330 340 350 360 CTQYIRHASS PMHSPEPDCV HELLGHVPML ADRTFAQFSQ NIGLASLGAS EEDIEKLSTL 370 380 390 400 410 420 YWFTVEFGLC KQGDGVKAYG AGLLSSYGEL VHSLSDEPER REFDPEAAAA EPYQDQNYQS 430 440 450 460 470 480 VYFVSESFTD AKEKLRVYAA GINRPFSVRF DPYTYSIEVL DNPLKIRGGL ESVKDELKVL TDALNVLA

References

[1]	"Tyrosine hydroxylase in the European eel (Anguilla anguilla): cDNA cloning, brain distribution, and phylogenetic analysis." Boularand S., Biguet N.F., Vidal B., Veron M., Mallet J., Vincent J.D., Dufour S., Vernier P. J. Neurochem. 71:460-470(1998) [PubMed: 9681435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ000731 mRNA. Translation: CAA04264.1.
3D structure databases
ProteinModelPortal	O42091.
SMR	O42091. Positions 150-488.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006841.
Family and domain databases
InterPro	IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. IPR005962. Tyr_3_mOase. IPR019773. Tyrosine_3-monooxygenase-like. IPR021164. Tyrosine_hydroxylase_CS. [Graphical view]
Gene3D	G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHER	PTHR11473. Aaa_hydroxylase. 1 hit.
Pfam	PF00351. Biopterin_H. 1 hit. PF12549. TOH_N. 1 hit. [Graphical view]
PIRSF	PIRSF000336. TH. 1 hit.
PRINTS	PR00372. FYWHYDRXLASE.
SUPFAM	SSF56534. Aaa_hydroxylase. 1 hit.
TIGRFAMs	TIGR01269. Tyr_3_monoox. 1 hit.
PROSITE	PS00367. BH4_AAA_HYDROXYL_1. 1 hit. PS51410. BH4_AAA_HYDROXYL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TY3H_ANGAN

Accession

Primary (citable) accession number: O42091

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 28, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program