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O42053 (NCAP_HRSVB) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nucleoprotein

Short name=Protein N
Alternative name(s):
Nucleocapsid protein
Gene names
Name:N
OrganismHuman respiratory syncytial virus B (strain B1) [Reference proteome]
Taxonomic identifier79692 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaePneumovirinaePneumovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

Subunit structure

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, interacts with the protein P and thereby positions the polymerase on the template. Interacts with protein M2-1; this interaction allows the association of nucleocapsid with the matrix protein, supposely to shut down virus transcriptase activity and initiate assembly and budding By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Sequence similarities

Belongs to the paramyxoviruses nucleocapsid family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Nucleoprotein
PRO_0000365782

Sequences

Sequence LengthMass (Da)Tools
O42053 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9A2B4E578E3B6D35

FASTA39143,411
        10         20         30         40         50         60 
MALSKVKLND TLNKDQLLSS SKYTIQRSTG DNIDTPNYDV QKHLNKLCGM LLITEDANHK 

        70         80         90        100        110        120 
FTGLIGMLYA MSRLGREDTI KILKDAGYHV KANGVDITTY RQDINGKEMK FEVLTLSSLT 

       130        140        150        160        170        180 
SEIQVNIEIE SRKSYKKMLK EMGEVAPEYR HDSPDCGMII LCIAALVITK LAAGDRSGLT 

       190        200        210        220        230        240 
AVIRRANNVL KNEIKRYKGL IPKDIANSFY EVFEKHPHLI DVFVHFGIAQ SSTRGGSRVE 

       250        260        270        280        290        300 
GIFAGLFMNA YGSGQVMLRW GVLAKSVKNI MLGHASVQAE MEQVVEVYEY AQKLGGEAGF 

       310        320        330        340        350        360 
YHILNNPKAS LLSLTQFPNF SSVVLGNAAG LGIMGEYRGT PRNQDLYDAA KAYAEQLKEN 

       370        380        390 
GVINYSVLDL TAEELEAIKN QLNPKEDDVE L 

« Hide

References

[1]"Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant."
Karron R.A., Buonagurio D.A., Georgiu A.F., Whitehead S.S., Adamus J.E., Clements-Mann M.L., Harris D.O., Randolph V.B., Udem S.A., Murphy B.R., Sidhu M.S.
Proc. Natl. Acad. Sci. U.S.A. 94:13961-13966(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF013254 Genomic RNA. Translation: AAB82431.1.
AF013255 Genomic RNA. Translation: AAB82442.1.
RefSeqNP_056858.1. NC_001781.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1489820.

Family and domain databases

InterProIPR004930. Pneumo_ncap.
[Graphical view]
PfamPF03246. Pneumo_ncap. 1 hit.
[Graphical view]
ProDomPD006438. Pneumo_ncap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNCAP_HRSVB
AccessionPrimary (citable) accession number: O42053
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families