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Protein

Nucleoprotein

Gene

N

Organism
Human respiratory syncytial virus B (strain B1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host PKR activity Source: UniProtKB-KW
  2. suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host PKR by virus, Viral immunoevasion

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Short name:
Protein N
Alternative name(s):
Nucleocapsid protein
Gene namesi
Name:N
OrganismiHuman respiratory syncytial virus B (strain B1)
Taxonomic identifieri79692 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaePneumovirinaePneumovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002472: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
  3. ribonucleoprotein complex Source: UniProtKB-KW
  4. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391NucleoproteinPRO_0000365782Add
BLAST

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, interacts with the protein P and thereby positions the polymerase on the template. Interacts with protein M2-1; this interaction allows the association of nucleocapsid with the matrix protein, supposely to shut down virus transcriptase activity and initiate assembly and budding (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004930. Pneumo_ncap.
[Graphical view]
PfamiPF03246. Pneumo_ncap. 1 hit.
[Graphical view]
ProDomiPD006438. Pneumo_ncap. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O42053-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSKVKLND TLNKDQLLSS SKYTIQRSTG DNIDTPNYDV QKHLNKLCGM
60 70 80 90 100
LLITEDANHK FTGLIGMLYA MSRLGREDTI KILKDAGYHV KANGVDITTY
110 120 130 140 150
RQDINGKEMK FEVLTLSSLT SEIQVNIEIE SRKSYKKMLK EMGEVAPEYR
160 170 180 190 200
HDSPDCGMII LCIAALVITK LAAGDRSGLT AVIRRANNVL KNEIKRYKGL
210 220 230 240 250
IPKDIANSFY EVFEKHPHLI DVFVHFGIAQ SSTRGGSRVE GIFAGLFMNA
260 270 280 290 300
YGSGQVMLRW GVLAKSVKNI MLGHASVQAE MEQVVEVYEY AQKLGGEAGF
310 320 330 340 350
YHILNNPKAS LLSLTQFPNF SSVVLGNAAG LGIMGEYRGT PRNQDLYDAA
360 370 380 390
KAYAEQLKEN GVINYSVLDL TAEELEAIKN QLNPKEDDVE L
Length:391
Mass (Da):43,411
Last modified:January 1, 1998 - v1
Checksum:i9A2B4E578E3B6D35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013254 Genomic RNA. Translation: AAB82431.1.
AF013255 Genomic RNA. Translation: AAB82442.1.
RefSeqiNP_056858.1. NC_001781.1.

Genome annotation databases

GeneIDi1489820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013254 Genomic RNA. Translation: AAB82431.1.
AF013255 Genomic RNA. Translation: AAB82442.1.
RefSeqiNP_056858.1. NC_001781.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489820.

Family and domain databases

InterProiIPR004930. Pneumo_ncap.
[Graphical view]
PfamiPF03246. Pneumo_ncap. 1 hit.
[Graphical view]
ProDomiPD006438. Pneumo_ncap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant."
    Karron R.A., Buonagurio D.A., Georgiu A.F., Whitehead S.S., Adamus J.E., Clements-Mann M.L., Harris D.O., Randolph V.B., Udem S.A., Murphy B.R., Sidhu M.S.
    Proc. Natl. Acad. Sci. U.S.A. 94:13961-13966(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_HRSVB
AccessioniPrimary (citable) accession number: O42053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.