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O42053

- NCAP_HRSVB

UniProt

O42053 - NCAP_HRSVB

Protein

Nucleoprotein

Gene

N

Organism
Human respiratory syncytial virus B (strain B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host PKR activity Source: UniProtKB-KW
    2. suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host PKR by virus, Viral immunoevasion

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Short name:
    Protein N
    Alternative name(s):
    Nucleocapsid protein
    Gene namesi
    Name:N
    OrganismiHuman respiratory syncytial virus B (strain B1)
    Taxonomic identifieri79692 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaePneumovirinaePneumovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000002472: Genome

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. host cell cytoplasm Source: UniProtKB-SubCell
    3. ribonucleoprotein complex Source: UniProtKB-KW
    4. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391NucleoproteinPRO_0000365782Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, interacts with the protein P and thereby positions the polymerase on the template. Interacts with protein M2-1; this interaction allows the association of nucleocapsid with the matrix protein, supposely to shut down virus transcriptase activity and initiate assembly and budding By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR004930. Pneumo_ncap.
    [Graphical view]
    PfamiPF03246. Pneumo_ncap. 1 hit.
    [Graphical view]
    ProDomiPD006438. Pneumo_ncap. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    O42053-1 [UniParc]FASTAAdd to Basket

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    MALSKVKLND TLNKDQLLSS SKYTIQRSTG DNIDTPNYDV QKHLNKLCGM    50
    LLITEDANHK FTGLIGMLYA MSRLGREDTI KILKDAGYHV KANGVDITTY 100
    RQDINGKEMK FEVLTLSSLT SEIQVNIEIE SRKSYKKMLK EMGEVAPEYR 150
    HDSPDCGMII LCIAALVITK LAAGDRSGLT AVIRRANNVL KNEIKRYKGL 200
    IPKDIANSFY EVFEKHPHLI DVFVHFGIAQ SSTRGGSRVE GIFAGLFMNA 250
    YGSGQVMLRW GVLAKSVKNI MLGHASVQAE MEQVVEVYEY AQKLGGEAGF 300
    YHILNNPKAS LLSLTQFPNF SSVVLGNAAG LGIMGEYRGT PRNQDLYDAA 350
    KAYAEQLKEN GVINYSVLDL TAEELEAIKN QLNPKEDDVE L 391
    Length:391
    Mass (Da):43,411
    Last modified:January 1, 1998 - v1
    Checksum:i9A2B4E578E3B6D35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013254 Genomic RNA. Translation: AAB82431.1.
    AF013255 Genomic RNA. Translation: AAB82442.1.
    RefSeqiNP_056858.1. NC_001781.1.

    Genome annotation databases

    GeneIDi1489820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013254 Genomic RNA. Translation: AAB82431.1 .
    AF013255 Genomic RNA. Translation: AAB82442.1 .
    RefSeqi NP_056858.1. NC_001781.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1489820.

    Family and domain databases

    InterProi IPR004930. Pneumo_ncap.
    [Graphical view ]
    Pfami PF03246. Pneumo_ncap. 1 hit.
    [Graphical view ]
    ProDomi PD006438. Pneumo_ncap. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant."
      Karron R.A., Buonagurio D.A., Georgiu A.F., Whitehead S.S., Adamus J.E., Clements-Mann M.L., Harris D.O., Randolph V.B., Udem S.A., Murphy B.R., Sidhu M.S.
      Proc. Natl. Acad. Sci. U.S.A. 94:13961-13966(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNCAP_HRSVB
    AccessioniPrimary (citable) accession number: O42053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3