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Protein

Ribonucleoside-diphosphate reductase

Gene

GAMMAHV.ORF61

Organism
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

DNA replicationUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:GAMMAHV.ORF61Imported
Synonyms:61Imported
OrganismiMurid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)Imported
Taxonomic identifieri33708 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiApodemus sylvaticus (European woodmouse) [TaxID: 10129]

Interactioni

Protein-protein interaction databases

DIPiDIP-47191N.
IntActiO41962. 1 interaction.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini568 – 59023RIBORED_LARGEInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

KOiK10807.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O41962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQTMDVEP VQTVNAIDAA IAELKLMAGH SHEANVLAGR LLHFKMREVC
60 70 80 90 100
TQTVAQFLDA FSSVLDEGLC AFIGNYSQSL DEMVQRYVSG GFAAVKENGY
110 120 130 140 150
LAAARFYDTY VLRNDVKYES VPHMFMRISA FCAYHCIQNE CLFKTLKHME
160 170 180 190 200
LDRGNVVENA MDLITYFFEM IASQQVCCAT PVMRSAGLRD ANLSSCFIFA
210 220 230 240 250
PALDSEEKTV DAVFSELTKL LACKSGVGMD LSTYSHGKNL HAVLKALDGQ
260 270 280 290 300
ITYFNDHNIR PVSVAAYMEI WHTNIMDFLT AKLPENPERC GNLFQGVCIP
310 320 330 340 350
EIFFRTYKND PESNWYLFDP KKAEVLTNTY GYMFSIAYAG LVEQGAYEAV
360 370 380 390 400
VPIKSVMFAL VSCIIKTGGP YILNKKAINR HDWHEWSTHQ YRAINCANLC
410 420 430 440 450
AEVIQYPGEN VSTCNLANIC LPKCLEDDKF VSGKSCLLTY EREFSIERLE
460 470 480 490 500
RATEAAVFII NACIHGGTLP TQRARRGQSD RSMGIGVQGL ADTFAMMGLG
510 520 530 540 550
YFDAGSEILD QKIAETLYFN ALNTSINFVK IGKGEPYANY EQSKHSIGVL
560 570 580 590 600
HWHDWDMCSP MVYTRDEWED LARSCEVHGV YNSQFVAYMP TAGTGQITGY
610 620 630 640 650
SDSFYPFYSS MSSKVSNKEE ILRPNMTLMS RMSDSEVQTL RECNWDIAKL
660 670 680 690 700
PEPLLQKYRI FLSAFDYEPS LYVRRAMLRA PFIDQSQSMT LFLNEDYASS
710 720 730 740 750
ASNIKNLLMY GWECGLKTLM YYCRIRKTAT SNEFECVRRN SQQKYVNCAD
760 770 780
GEGAGGEEPS ENCIKAEGAT CSLSVGASCL HCQ
Length:783
Mass (Da):88,008
Last modified:January 1, 1998 - v1
Checksum:i13538196A4022C3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97553 Genomic DNA. Translation: AAB66451.1.
AF105037 Genomic DNA. Translation: AAF19325.1.
RefSeqiNP_044899.1. NC_001826.2.

Genome annotation databases

GeneIDi1497127.
KEGGivg:1497127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97553 Genomic DNA. Translation: AAB66451.1.
AF105037 Genomic DNA. Translation: AAF19325.1.
RefSeqiNP_044899.1. NC_001826.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47191N.
IntActiO41962. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1497127.
KEGGivg:1497127.

Phylogenomic databases

KOiK10807.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genetic content and preliminary transcriptional analysis of a representative region of murine gammaherpesvirus 68."
    Mackett M., Stewart J.P., de V Pepper S., Chee M., Efstathiou S., Nash A.A., Arrand J.R.
    J. Gen. Virol. 78:1425-1433(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported.
  2. "Complete sequence and genomic analysis of murine gammaherpesvirus 68."
    Virgin H.W., Latreille P., Wamsley P., Hallsworth K., Weck K.E., Dal Canto A.J., Speck S.H.
    J. Virol. 71:5894-5904(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported and WUMSImported.
  3. "Genetic content of murine gammaherpesviruses."
    Milligan S., Efstathiou S., Stewart J.P., Nash A.A., Davison A.J.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported.
  4. Lynn T., Virgin H.W.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WUMSImported.

Entry informationi

Entry nameiO41962_MHV68
AccessioniPrimary (citable) accession number: O41962
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.