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Protein
Submitted name:

M3

Gene

GAMMAHV.M3

Organism
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
M3Imported
Submitted name:
M3 proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:GAMMAHV.M3Imported
Synonyms:M3Imported
OrganismiMurid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)Imported
Taxonomic identifieri33708 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiApodemus sylvaticus (European woodmouse) [TaxID: 10129]

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 71Combined sources
Disulfide bondi90 ↔ 219Combined sources
Disulfide bondi242 ↔ 288Combined sources
Disulfide bondi259 ↔ 286Combined sources
Disulfide bondi342 ↔ 361Combined sources

Interactioni

Protein-protein interaction databases

DIPiDIP-45330N.
IntActiO41925. 3 interactions.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MKFX-ray2.10A/B25-406[»]
1ML0X-ray2.80A25-406[»]
2NYZX-ray2.60A/B25-406[»]
2NZ1X-ray2.50A/B/X25-406[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.60.40.1330. 1 hit.
2.60.40.1340. 1 hit.
InterProiIPR015950. Chemokine-bd_M3_sub1_vir.
IPR015951. Chemokine-bd_M3_sub2_vir.
IPR015296. Chemokine-bd_M3_vir.
[Graphical view]
PfamiPF09213. M3. 1 hit.
[Graphical view]
SUPFAMiSSF82046. SSF82046. 1 hit.

Sequencei

Sequence statusi: Complete.

O41925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLSTSVLI KCCILLLAGG LAESLTLGLA PALSTHSSGV STQSVDLSQI
60 70 80 90 100
KRGDEIQAHC LTPAETEVTE CAGILKDVLS KNLHELQGLC NVKNKMGVPW
110 120 130 140 150
VSVEELGQEI ITGRLPFPSV GGTPVNDLVR VLVVAESNTP EETPEEEFYA
160 170 180 190 200
YVELQTELYT FGLSDDNVVF TSDYMTVWMI DIPKSYVDVG MLTRATFLEQ
210 220 230 240 250
WPGAKVTVMI PYSSTFTWCG ELGAISEESA PQPSLSARSP VCKNSARYST
260 270 280 290 300
SKFCEVDGCT AETGMEKMSL LTPFGGPPQQ AKMNTCPCYY KYSVSPLPAM
310 320 330 340 350
DHLILADLAG LDSLTSPVYV MAAYFDSTHE NPVRPSSKLY HCALQMTSHD
360 370 380 390 400
GVWTSTSSEQ CPIRLVEGQS QNVLQVRVAP TSMPNLVGVS LMLEGQQYRL

EYFGDH
Length:406
Mass (Da):44,231
Last modified:January 1, 1998 - v1
Checksum:i7C8B26A064E20DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97553 Genomic DNA. Translation: AAB66428.1.
AF127083 Genomic DNA. Translation: AAD29402.1.
AF105037 Genomic DNA. Translation: AAF19271.1.
GQ421298 Genomic DNA. Translation: ACV65509.1.
RefSeqiNP_044843.1. NC_001826.2.

Genome annotation databases

GeneIDi1497185.
KEGGivg:1497185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97553 Genomic DNA. Translation: AAB66428.1.
AF127083 Genomic DNA. Translation: AAD29402.1.
AF105037 Genomic DNA. Translation: AAF19271.1.
GQ421298 Genomic DNA. Translation: ACV65509.1.
RefSeqiNP_044843.1. NC_001826.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MKFX-ray2.10A/B25-406[»]
1ML0X-ray2.80A25-406[»]
2NYZX-ray2.60A/B25-406[»]
2NZ1X-ray2.50A/B/X25-406[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-45330N.
IntActiO41925. 3 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1497185.
KEGGivg:1497185.

Family and domain databases

Gene3Di2.60.40.1330. 1 hit.
2.60.40.1340. 1 hit.
InterProiIPR015950. Chemokine-bd_M3_sub1_vir.
IPR015951. Chemokine-bd_M3_sub2_vir.
IPR015296. Chemokine-bd_M3_vir.
[Graphical view]
PfamiPF09213. M3. 1 hit.
[Graphical view]
SUPFAMiSSF82046. SSF82046. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genetic content and preliminary transcriptional analysis of a representative region of murine gammaherpesvirus 68."
    Mackett M., Stewart J.P., de V Pepper S., Chee M., Efstathiou S., Nash A.A., Arrand J.R.
    J. Gen. Virol. 78:1425-1433(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported.
  2. "Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latency."
    Bowden R.J., Simas J.P., Davis A.J., Efstathiou S.
    J. Gen. Virol. 78:1675-1687(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported.
  3. "Complete sequence and genomic analysis of murine gammaherpesvirus 68."
    Virgin H.W., Latreille P., Wamsley P., Hallsworth K., Weck K.E., Dal Canto A.J., Speck S.H.
    J. Virol. 71:5894-5904(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported and WUMSImported.
  4. "Genetic content of murine gammaherpesviruses."
    Milligan S., Efstathiou S., Stewart J.P., Nash A.A., Davison A.J.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: G2.4Imported.
  5. "Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein."
    van Berkel V., Preiter K., Virgin H.W.IV., Speck S.H.
    J. Virol. 73:4524-4529(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WUMSImported.
  6. "Structural basis of chemokine sequestration by a herpesvirus decoy receptor."
    Alexander J.M., Nelson C.A., van Berkel V., Lau E.K., Studts J.M., Brett T.J., Speck S.H., Handel T.M., Virgin H.W., Fremont D.H.
    Cell 111:343-356(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 25-406, DISULFIDE BONDS.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WUMSImported.
  8. "Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor."
    Alexander-Brett J.M., Fremont D.H.
    J. Exp. Med. 204:3157-3172(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 25-406, DISULFIDE BONDS.
  9. "Partial sequence and analysis of Murine herpesvirus strain 4556 (MHV4556) genome."
    Halasova Z., Valovicova M., Belvoncikova P., Pancik P., Rezuchova I., Kudelova M.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 4556Imported.

Entry informationi

Entry nameiO41925_MHV68
AccessioniPrimary (citable) accession number: O41925
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: April 13, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.