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O41156

- THYX_PBCV1

UniProt

O41156 - THYX_PBCV1

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Protein

Probable thymidylate synthase

Gene

A674R

Organism
Paramecium bursaria Chlorella virus 1 (PBCV-1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.PROSITE-ProRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP+.PROSITE-ProRule annotation

Cofactori

Binds 1 FAD per subunit.PROSITE-ProRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. thymidylate synthase (FAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. dTMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thymidylate synthase (EC:2.1.1.148)
Short name:
TS
Short name:
TSase
Gene namesi
Ordered Locus Names:A674R
OrganismiParamecium bursaria Chlorella virus 1 (PBCV-1)
Taxonomic identifieri10506 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostiChlorella [TaxID: 114049]
ProteomesiUP000000862: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Probable thymidylate synthasePRO_0000175603Add
BLAST

Structurei

Secondary structure

1
216
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1110
Helixi19 – 2810
Helixi35 – 384
Helixi41 – 5010
Helixi54 – 585
Beta strandi61 – 699
Helixi70 – 767
Beta strandi82 – 865
Turni89 – 913
Helixi126 – 14621
Helixi151 – 1544
Helixi155 – 1573
Beta strandi162 – 17110
Helixi172 – 18211
Helixi189 – 20517
Helixi207 – 2126

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CFAX-ray2.30A/B1-216[»]
4FZBX-ray2.59A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P2-216[»]
ProteinModelPortaliO41156.
SMRiO41156. Positions 1-216.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO41156.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 216216ThyXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thymidylate synthase ThyX family.Curated
Contains 1 thyX (flavin-dependent thymidylate synthase) domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR003669. Thymidylate_synthase_ThyX.
[Graphical view]
PfamiPF02511. Thy1. 1 hit.
[Graphical view]
SUPFAMiSSF69796. SSF69796. 1 hit.
TIGRFAMsiTIGR02170. thyX. 1 hit.
PROSITEiPS51331. THYX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O41156-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAKLISVTK PVVEGVNTAE ELIAYAARVS NPENQINNKT ASGLLKYCIR
60 70 80 90 100
HKHWSIFETA FMTLELKTSR GIAAQVLRHR SFHFQEFSQR YASVMETPPP
110 120 130 140 150
HQARFQDHKN RQNSLDTVPE DDQTWWATEQ EKLYAQSMEL YNKALEKGIA
160 170 180 190 200
KECARFILPL STPTTIYMSG TIRDWIHYIE LRTSNGTQRE HIDLANACKE
210
IFIKEFPSIA KALDWV
Length:216
Mass (Da):24,902
Last modified:January 1, 1998 - v1
Checksum:i633931516599A46C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF411744 Genomic DNA. Translation: AAC96983.1.
PIRiT18176.
RefSeqiNP_049030.1. NC_000852.5.

Genome annotation databases

GeneIDi918188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF411744 Genomic DNA. Translation: AAC96983.1 .
PIRi T18176.
RefSeqi NP_049030.1. NC_000852.5.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CFA X-ray 2.30 A/B 1-216 [» ]
4FZB X-ray 2.59 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 2-216 [» ]
ProteinModelPortali O41156.
SMRi O41156. Positions 1-216.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1075203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 918188.

Miscellaneous databases

EvolutionaryTracei O41156.

Family and domain databases

InterProi IPR003669. Thymidylate_synthase_ThyX.
[Graphical view ]
Pfami PF02511. Thy1. 1 hit.
[Graphical view ]
SUPFAMi SSF69796. SSF69796. 1 hit.
TIGRFAMsi TIGR02170. thyX. 1 hit.
PROSITEi PS51331. THYX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of 74 kb of DNA located at the right end of the 330-kb chlorella virus PBCV-1 genome."
    Li Y., Lu Z., Sun L., Ropp S., Kutish G.F., Rock D.L., van Etten J.L.
    Virology 237:360-377(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTHYX_PBCV1
AccessioniPrimary (citable) accession number: O41156
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3