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O41156 (THYX_PBCV1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.148
Gene names
Ordered Locus Names:A674R
OrganismParamecium bursaria Chlorella virus 1 (PBCV-1) [Reference proteome]
Taxonomic identifier10506 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostChlorella [TaxID: 114049]

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP+.

Cofactor

Binds 1 FAD per subunit By similarity.

Sequence similarities

Belongs to the thymidylate synthase ThyX family.

Contains 1 thyX (flavin-dependent thymidylate synthase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Probable thymidylate synthase
PRO_0000175603

Regions

Domain1 – 216216ThyX

Secondary structure

.............................. 216
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O41156 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 633931516599A46C

FASTA21624,902
        10         20         30         40         50         60 
MSAKLISVTK PVVEGVNTAE ELIAYAARVS NPENQINNKT ASGLLKYCIR HKHWSIFETA 

        70         80         90        100        110        120 
FMTLELKTSR GIAAQVLRHR SFHFQEFSQR YASVMETPPP HQARFQDHKN RQNSLDTVPE 

       130        140        150        160        170        180 
DDQTWWATEQ EKLYAQSMEL YNKALEKGIA KECARFILPL STPTTIYMSG TIRDWIHYIE 

       190        200        210 
LRTSNGTQRE HIDLANACKE IFIKEFPSIA KALDWV 

« Hide

References

[1]"Analysis of 74 kb of DNA located at the right end of the 330-kb chlorella virus PBCV-1 genome."
Li Y., Lu Z., Sun L., Ropp S., Kutish G.F., Rock D.L., van Etten J.L.
Virology 237:360-377(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JF411744 Genomic DNA. Translation: AAC96983.1.
PIRT18176.
RefSeqNP_049030.1. NC_000852.5.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CFAX-ray2.30A/B1-216[»]
4FZBX-ray2.59A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P2-216[»]
ProteinModelPortalO41156.
SMRO41156. Positions 1-216.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1075203.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID918188.

Family and domain databases

InterProIPR003669. Thymidylate_synthase_ThyX.
[Graphical view]
PfamPF02511. Thy1. 1 hit.
[Graphical view]
SUPFAMSSF69796. SSF69796. 1 hit.
TIGRFAMsTIGR02170. thyX. 1 hit.
PROSITEPS51331. THYX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO41156.

Entry information

Entry nameTHYX_PBCV1
AccessionPrimary (citable) accession number: O41156
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references