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Protein
Submitted name:

Histone H3K27 methylase

Gene

A612L

Organism
Paramecium bursaria Chlorella virus 1 (PBCV-1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei16 – 161S-adenosyl-L-homocysteine 2; via carbonyl oxygenCombined sources
Binding sitei50 – 501S-adenosyl-L-homocysteine 1Combined sources
Binding sitei50 – 501S-adenosyl-L-homocysteine 2Combined sources
Binding sitei66 – 661S-adenosyl-L-homocysteine 2Combined sources
Binding sitei70 – 701S-adenosyl-L-homocysteine 2; via amide nitrogen and carbonyl oxygenCombined sources
Binding sitei109 – 1091S-adenosyl-L-homocysteine 1Combined sources
Binding sitei119 – 1191S-adenosyl-L-homocysteine 1Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Histone H3K27 methylaseImported
Gene namesi
Name:A612LImported
OrganismiParamecium bursaria Chlorella virus 1 (PBCV-1)Imported
Taxonomic identifieri10506 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostiChlorella [TaxID: 114049]
Proteomesi
  • UP000000862 Componenti: Genome

Interactioni

Protein-protein interaction databases

DIPiDIP-36309N.
IntActiO41094. 1 interaction.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N3JNMR-A/B1-119[»]
2G46NMR-A/B1-119[»]
3KMAX-ray1.60A/B1-119[»]
3KMJX-ray1.85A1-119[»]
3KMTX-ray1.78A/B/C1-119[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO41094.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 106103SETInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 163S-adenosyl-L-homocysteine 1 bindingCombined sources
Regioni69 – 702S-adenosyl-L-homocysteine 1 bindingCombined sources

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

KOiK07117.

Family and domain databases

InterProiIPR009207. A612L_SET_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF022536. A612L_SET. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O41094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNDRVIVKK SPLGGYGVFA RKSFEKGELV EECLCIVRHN DDWGTALEDY
60 70 80 90 100
LFSRKNMSAM ALGFGAIFNH SKDPNARHEL TAGLKRMRIF TIKPIAIGEE
110
ITISYGDDYW LSRPRLTQN
Length:119
Mass (Da):13,587
Last modified:January 1, 1998 - v1
Checksum:i9E57A5E72781E13E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF411744 Genomic DNA. Translation: AAC96946.1.
PIRiT18114.
RefSeqiNP_048968.1. NC_000852.5.

Genome annotation databases

GeneIDi918052.
KEGGivg:918052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF411744 Genomic DNA. Translation: AAC96946.1.
PIRiT18114.
RefSeqiNP_048968.1. NC_000852.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N3JNMR-A/B1-119[»]
2G46NMR-A/B1-119[»]
3KMAX-ray1.60A/B1-119[»]
3KMJX-ray1.85A1-119[»]
3KMTX-ray1.78A/B/C1-119[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-36309N.
IntActiO41094. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi918052.
KEGGivg:918052.

Phylogenomic databases

KOiK07117.

Miscellaneous databases

EvolutionaryTraceiO41094.

Family and domain databases

InterProiIPR009207. A612L_SET_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF022536. A612L_SET. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of 45 kb of DNA located at the left end of the chlorella virus PBCV-1 genome."
    Lu Z., Li Y., Zhang Y., Kutish G.F., Rock D.L., Van Etten J.L.
    Virology 206:339-352(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Analysis of 43 kb of the Chlorella virus PBCV-1 330-kb genome: map positions 45 to 88."
    Li Y., Lu Z., Burbank D.E., Kutish G.F., Rock D.L., Van Etten J.L.
    Virology 212:134-150(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Analysis of 94 kb of the chlorella virus PBCV-1 330-kb genome: map positions 88 to 182."
    Lu Z., Li Y., Que Q., Kutish G.F., Rock D.L., Van Etten J.L.
    Virology 216:102-123(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Analysis of 76 kb of the chlorella virus PBCV-1 330-kb genome: map positions 182 to 258."
    Kutish G.F., Li Y., Lu Z., Furuta M., Rock D.L., Van Etten J.L.
    Virology 223:303-317(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Analysis of 74 kb of DNA located at the right end of the 330-kb chlorella virus PBCV-1 genome."
    Li Y., Lu Z., Sun L., Ropp S., Kutish G.F., Rock D.L., Van Etten J.L.
    Virology 237:360-377(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Characterization of a beta-1,3-glucanase encoded by chlorella virus PBCV-1."
    Sun L., Gurnon J.R., Adams B.J., Graves M.V., Van Etten J.L.
    Virology 276:27-36(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3."
    Manzur K.L., Farooq A., Zeng L., Plotnikova O., Koch A.W., Sachchidanand, Zhou M.M.
    Nat. Struct. Biol. 10:187-196(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  9. "Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase."
    Qian C., Wang X., Manzur K., Sachchidanand, Farooq A., Zeng L., Wang R., Zhou M.M.
    J. Mol. Biol. 359:86-96(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.
  10. "Microarray analysis of Paramecium bursaria chlorella virus 1 transcription."
    Yanai-Balser G.M., Duncan G.A., Eudy J.D., Wang D., Li X., Agarkova I.V., Dunigan D.D., Van Etten J.L.
    J. Virol. 84:532-542(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "Dimerization of a viral SET protein endows its function."
    Wei H., Zhou M.M.
    Proc. Natl. Acad. Sci. U.S.A. 107:18433-18438(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

Entry informationi

Entry nameiO41094_PBCV1
AccessioniPrimary (citable) accession number: O41094
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.