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O41033

- DUT_PBCV1

UniProt

O41033 - DUT_PBCV1

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

A551L

Organism
Paramecium bursaria Chlorella virus 1 (PBCV-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Ordered Locus Names:A551L
    OrganismiParamecium bursaria Chlorella virus 1 (PBCV-1)
    Taxonomic identifieri10506 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
    Virus hostiChlorella [TaxID: 114049]
    ProteomesiUP000000862: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 141141Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182969Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO41033.
    SMRiO41033. Positions 6-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O41033-1 [UniParc]FASTAAdd to Basket

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    MSSLLVKKLV ESATTPMRGS EGAAGYDISS VEDVVVPAMG RIAVSTGISI    50
    RVPNGTYGRI APRSGLAYKY GIDVLAGVID SDYRGELKAI LYNTTERDYI 100
    IKKGDRIAQL ILEQIVTPDV AVVLELEDTA RGGGGFGSTG I 141
    Length:141
    Mass (Da):14,879
    Last modified:January 1, 1998 - v1
    Checksum:i3D0734C9C9BD70B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF411744 Genomic DNA. Translation: AAC96912.1.
    PIRiT18053.
    RefSeqiNP_048907.1. NC_000852.5.

    Genome annotation databases

    GeneIDi918013.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF411744 Genomic DNA. Translation: AAC96912.1 .
    PIRi T18053.
    RefSeqi NP_048907.1. NC_000852.5.

    3D structure databases

    ProteinModelPortali O41033.
    SMRi O41033. Positions 6-123.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 918013.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of 74 kb of DNA located at the right end of the 330-kb chlorella virus PBCV-1 genome."
      Li Y., Lu Z., Sun L., Ropp S., Kutish G.F., Rock D.L., van Etten J.L.
      Virology 237:360-377(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_PBCV1
    AccessioniPrimary (citable) accession number: O41033
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3