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Protein
Submitted name:

Dihydrofolate reductase

Gene

ORF2

Organism
Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrofolate reductaseImported
Submitted name:
ORF 02Imported
Gene namesi
Name:ORF2Imported
OrganismiHuman herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)Imported
Taxonomic identifieri37296 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 184181DHFR (dihydrofolate reductase)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O40919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTLYCVVA VDTKLGIGKN RCLPWPALRG DMRRFRQLTT DCAPGKQNMV
60 70 80 90 100
VMGRRTWLSI PAGCRPLAGR INVVLSRTLE TPPPGAHFLA SSLDAALGLA
110 120 130 140 150
RSPELAQQID KVWVIGGGNL YREALTGPWP VRLFLTRVLH DFACDVFLSH
160 170 180 190 200
DSLAAYARVN PKPGEQERVF QERGIFYMFE TYIKVTQSSD TALPDLERPR
210
SATPPFSETS
Length:210
Mass (Da):23,344
Last modified:January 1, 1998 - v1
Checksum:i1F7D0AD5D82690D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93872 Genomic DNA. Translation: AAB62675.1.
HQ404500 Genomic DNA. Translation: ADQ57887.1.
JX228174 Genomic DNA. Translation: AFQ99136.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93872 Genomic DNA. Translation: AAB62675.1.
HQ404500 Genomic DNA. Translation: ADQ57887.1.
JX228174 Genomic DNA. Translation: AFQ99136.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?"
    Neipel F., Albrecht J.C., Fleckenstein B.
    J. Virol. 71:4187-4192(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome of human herpesvirus 8 cloned from Kaposi's sarcoma."
    Neipel F., Albrecht J.-C., Ensser A., Huang Y.-Q., Li J.J., Friedman-Kien A.E., Fleckenstein B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome contains a duplication of a long unique-region fragment within the terminal repeat region."
    Yakushko Y., Hackmann C., Gunther T., Ruckert J., Henke M., Koste L., Alkharsah K., Bohne J., Grundhoff A., Schulz T.F., Henke-Gendo C.
    J. Virol. 85:4612-4617(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KSHV-BAC36Imported.
  4. "Kaposi's Sarcoma Herpesvirus K15 Protein Contributes to Virus-Induced Angiogenesis by Recruiting PLCgamma1 and Activating NFAT1-dependent RCAN1 Expression."
    Bala K., Bosco R., Gramolelli S., Haas D.A., Kati S., Pietrek M., Havemeier A., Yakushko Y., Singh V.V., Dittrich-Breiholz O., Kracht M., Schulz T.F.
    PLoS Pathog. 8:E1002927-E1002927(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KSHV-BAC36-deltaK15Imported.

Entry informationi

Entry nameiO40919_HHV8
AccessioniPrimary (citable) accession number: O40919
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.