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O40627 (NSP1_ROTHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (strain Human/Japan/K8/1977 G1-P3A[9]-Ix-Rx-Cx-Mx-A1-Nx-Tx-Ex-H3) (RV-A)
Taxonomic identifier39012 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Non-structural protein 1
PRO_0000369083

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region313 – 486174Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
O40627 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 0C96042E585EA63A

FASTA48657,680
        10         20         30         40         50         60 
MATFKDACYH YKRINKLNNN SLKLGVNDTW RPSPPTKYKG WCLDCCQHTD LTYCSGCTMY 

        70         80         90        100        110        120 
HVCQWCSQYG RCFLDNEPHL LRMRTFKNEV TKDDLKNLID MYETLFPMNH KIVCRFINTA 

       130        140        150        160        170        180 
RQHKCRNECM TQWYNHLLMP ITLQSLSIEL DGDVYYVFGY YDNMNNINQT PFSFINLVDI 

       190        200        210        220        230        240 
YDKLLLDDVN FTRMSFLPAS LQQEYALRYF SKSRFINEQR KCVNDSHFSI NVLENLHNPS 

       250        260        270        280        290        300 
FKIQITRNCS ELSFDWNEAC KLVKNVSAYF DMLKTSHIEF YSVSTRCRIF TQCKLKMASK 

       310        320        330        340        350        360 
LIKPNYITSN HKTLATEVHN CKWCSVNNSY TVWNDFRIKK IYDNIFNFLR ALVKSNVNIG 

       370        380        390        400        410        420 
HCSSQEKIYE YVKDVLNVCD DERWKTSIME IFNCLEPVEL DDVKYVLFNH EINWDVINVL 

       430        440        450        460        470        480 
VHSIGKVPQI LTLENVITIM QSIIYEWFDI RYMRNTPMVT FTIDKLRRLY TGLKTVEYDS 


GISDIE 

« Hide

References

[1]"Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains."
Kojima K., Taniguchi K., Kobayashi N.
Arch. Virol. 141:1-12(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38152 Genomic RNA. Translation: BAA20543.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
IPR001005. SANT/Myb.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
SMARTSM00717. SANT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTHJ
AccessionPrimary (citable) accession number: O40627
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families