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O40626

- NSP1_ROTH6

UniProt

O40626 - NSP1_ROTH6

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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus A (strain Human/Indonesia/69M/1980 G8-P4[10]-I2-R2-C2-M2-A2-N2-T2-E2-H2) (RV-A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 7938Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
  3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Short name:
NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name:
NS53
OrganismiRotavirus A (strain Human/Indonesia/69M/1980 G8-P4[10]-I2-R2-C2-M2-A2-N2-T2-E2-H2) (RV-A)
Taxonomic identifieri10947 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000001455: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Non-structural protein 1PRO_0000369081Add
BLAST

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation (By similarity).By similarity

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8181RNA-bindingBy similarityAdd
BLAST
Regioni82 – 17695Important for cytoskeleton localizationBy similarityAdd
BLAST
Regioni313 – 486174Interaction with IRF3By similarityAdd
BLAST

Domaini

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity (By similarity).By similarity

Sequence similaritiesi

Belongs to the rotavirus A NSP1 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 7938Sequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamiPF00981. Rota_NS53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O40626-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATFKDACYQ YKKLNKLNNA ILKLGANDVW RSSTLTKRKG WCLDCCQHTD
60 70 80 90 100
LTYCQGCLIY HVCEWCSQYS RCFLDDDPHL LRMRTFRNEV TKSDLENLIN
110 120 130 140 150
MYDTLFPINQ KIVNKFTNII KQHKCRNEYL TQWYNHFLMP ITLQSLSIEL
160 170 180 190 200
DGDIYYIFGY YDDMHKINQT PFSFANLINK YDVLLLDSIN FDRMAFLPLT
210 220 230 240 250
LQQEYALRYF SKSRFITERR KYIETLHFSD NILNNLHNPN FTLQVIRNCS
260 270 280 290 300
NMSVEWNKAC NLIRNISDYF DILKSSHTES YNISPRCRMF TQYKLKIASK
310 320 330 340 350
LIKPNYVASN HNSLATEVHN CKWCSINNNS IVWTDFRIKN VYNDVFNFIR
360 370 380 390 400
ALVKSNLYVG HCSSEERIYE SIKDILNVCK ENEWNMLVTE IFNQLDPIKL
410 420 430 440 450
NEDSYVLLNY EINWNVMNVL INSIGKIPKI LTLNDVISIL RIIIYDWFDI
460 470 480
RFMRNTPMTT FTVNKLKQLY EKDKTAEYDS GISDVE
Length:486
Mass (Da):57,766
Last modified:April 14, 2009 - v2
Checksum:iAD2D967C72498467
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31T → S in CAA83550. 1 PublicationCurated
Sequence conflicti23 – 253KLG → NLP in CAA83550. 1 PublicationCurated
Sequence conflicti42 – 421C → Y in CAA83550. 1 PublicationCurated
Sequence conflicti188 – 1881S → T in BAA20542. (PubMed:8629937)Curated
Sequence conflicti247 – 2471R → T in BAA20542. (PubMed:8629937)Curated
Sequence conflicti361 – 3611H → D in BAA20542. (PubMed:8629937)Curated
Sequence conflicti445 – 4451Y → D in CAA83550. 1 PublicationCurated
Sequence conflicti459 – 4591T → S in CAA83550. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38151 Genomic RNA. Translation: BAA20542.1.
Z32552 Genomic RNA. Translation: CAA83550.1.
EF672557 Genomic DNA. Translation: ABV53229.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38151 Genomic RNA. Translation: BAA20542.1 .
Z32552 Genomic RNA. Translation: CAA83550.1 .
EF672557 Genomic DNA. Translation: ABV53229.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002148. Rotavirus_NSP1.
[Graphical view ]
Pfami PF00981. Rota_NS53. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains."
    Kojima K., Taniguchi K., Kobayashi N.
    Arch. Virol. 141:1-12(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. McCrae M.A.
    Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions."
    Heiman E.M., McDonald S.M., Barro M., Taraporewala Z.F., Bar-Magen T., Patton J.T.
    J. Virol. 82:11106-11116(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNSP1_ROTH6
AccessioniPrimary (citable) accession number: O40626
Secondary accession number(s): B3SRQ4, Q82042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3