Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O39930

- O39930_9HEPC

UniProt

O39930 - O39930_9HEPC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

RNA-dependent RNA-polymerase

Gene

NS5b

Organism
Hepatitis C virus
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

Viral RNA replicationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
RNA-dependent RNA-polymeraseImported
Gene namesi
Name:NS5bImported
OrganismiHepatitis C virusImported
Taxonomic identifieri11103 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Structurei

3D structure databases

ProteinModelPortaliO39930.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO39930.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O39930-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SMSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSASLRQK
60 70 80 90 100
KVTFDRLQVL DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK
110 120 130 140 150
FGYGAKDVRN LSSKAVNHIR SVWKDLLEDT ETPIDTTIMA KNEVFCVQPE
160 170 180 190 200
KGGRKPARLI VFPDLGVRVC EKMALYDVVS TLPQAVMGSS YGFQYSPGQR
210 220 230 240 250
VEFLVNTWKS KKCPMGFSYD TRCFDSTVTE NDIRVEESIY QCCDLAPEAR
260 270 280 290 300
QAIRSLTERL YIGGPLTNSK GQNCGYRRCR ASGVLTTSCG NTLTCYLKAS
310 320 330 340 350
AACRAAKLQD CTMLVCGDDL VVICESAGTQ EDAASLRAFT EAMTRYSAPP
360 370 380 390 400
GDPPQPEYDL ELITSCSSNV SVAHDASGKR VYYLTRDPTT PLARAAWETA
410 420 430 440 450
RHTPVNSWLG NIIMYAPTLW ARMILMTHFF SILLAQEQLE KALDCQIYGA
460 470 480 490 500
CYSIEPLDLP QIIQRLHGLS AFSLHSYSPG EINRVASCLR KLGVPPLRVW
510 520 530 540 550
RHRARSVRAR LLSQGGRAAT CGKYLFNWAV RTKLKLTPIP AASQLDLSSW
560 570 580 590
FVAGYSGGDI YHSLSRARPR WFMWCLLLLS VGVGIYLLPN R
Length:591
Mass (Da):65,754
Last modified:January 1, 1998 - v1
Checksum:i6FA9C2F970260349
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97730 Genomic RNA. Translation: CAB10747.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97730 Genomic RNA. Translation: CAB10747.1 .

3D structure databases

ProteinModelPortali O39930.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

euHCVdbi Z97730.

Miscellaneous databases

EvolutionaryTracei O39930.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity."
    Lohmann V., Korner F., Herian U., Bartenschlager R.
    J. Virol. 71:8416-8428(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO39930_9HEPC
AccessioniPrimary (citable) accession number: O39930
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)