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O39930

- O39930_9HEPC

UniProt

O39930 - O39930_9HEPC

Protein
Submitted name:

RNA-dependent RNA-polymerase

Gene

NS5b

Organism
Hepatitis C virus
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase

    Keywords - Biological processi

    Viral RNA replicationSAAS annotation

    Keywords - Ligandi

    Nucleotide-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    RNA-dependent RNA-polymeraseImported
    Gene namesi
    Name:NS5bImported
    OrganismiHepatitis C virusImported
    Taxonomic identifieri11103 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

    Structurei

    3D structure databases

    ProteinModelPortaliO39930.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO39930.

    Family & Domainsi

    Sequence similaritiesi

    Contains RdRp catalytic domain.SAAS annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O39930-1 [UniParc]FASTAAdd to Basket

    « Hide

    SMSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSASLRQK    50
    KVTFDRLQVL DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK 100
    FGYGAKDVRN LSSKAVNHIR SVWKDLLEDT ETPIDTTIMA KNEVFCVQPE 150
    KGGRKPARLI VFPDLGVRVC EKMALYDVVS TLPQAVMGSS YGFQYSPGQR 200
    VEFLVNTWKS KKCPMGFSYD TRCFDSTVTE NDIRVEESIY QCCDLAPEAR 250
    QAIRSLTERL YIGGPLTNSK GQNCGYRRCR ASGVLTTSCG NTLTCYLKAS 300
    AACRAAKLQD CTMLVCGDDL VVICESAGTQ EDAASLRAFT EAMTRYSAPP 350
    GDPPQPEYDL ELITSCSSNV SVAHDASGKR VYYLTRDPTT PLARAAWETA 400
    RHTPVNSWLG NIIMYAPTLW ARMILMTHFF SILLAQEQLE KALDCQIYGA 450
    CYSIEPLDLP QIIQRLHGLS AFSLHSYSPG EINRVASCLR KLGVPPLRVW 500
    RHRARSVRAR LLSQGGRAAT CGKYLFNWAV RTKLKLTPIP AASQLDLSSW 550
    FVAGYSGGDI YHSLSRARPR WFMWCLLLLS VGVGIYLLPN R 591
    Length:591
    Mass (Da):65,754
    Last modified:January 1, 1998 - v1
    Checksum:i6FA9C2F970260349
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97730 Genomic RNA. Translation: CAB10747.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97730 Genomic RNA. Translation: CAB10747.1 .

    3D structure databases

    ProteinModelPortali O39930.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    euHCVdbi Z97730.

    Miscellaneous databases

    EvolutionaryTracei O39930.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity."
      Lohmann V., Korner F., Herian U., Bartenschlager R.
      J. Virol. 71:8416-8428(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiO39930_9HEPC
    AccessioniPrimary (citable) accession number: O39930
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)