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O39930

- O39930_9HEPC

UniProt

O39930 - O39930_9HEPC

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Protein
Submitted name: RNA-dependent RNA-polymerase
Gene
NS5b
Organism
Hepatitis C virus
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotations

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotations, Transferase

Keywords - Biological processi

Viral RNA replicationSAAS annotations

Keywords - Ligandi

Nucleotide-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
RNA-dependent RNA-polymeraseImported
Gene namesi
Name:NS5bImported
OrganismiHepatitis C virusImported
Taxonomic identifieri11103 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Structurei

3D structure databases

ProteinModelPortaliO39930.

Miscellaneous databases

EvolutionaryTraceiO39930.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotations

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O39930-1 [UniParc]FASTAAdd to Basket

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SMSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSASLRQK    50
KVTFDRLQVL DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK 100
FGYGAKDVRN LSSKAVNHIR SVWKDLLEDT ETPIDTTIMA KNEVFCVQPE 150
KGGRKPARLI VFPDLGVRVC EKMALYDVVS TLPQAVMGSS YGFQYSPGQR 200
VEFLVNTWKS KKCPMGFSYD TRCFDSTVTE NDIRVEESIY QCCDLAPEAR 250
QAIRSLTERL YIGGPLTNSK GQNCGYRRCR ASGVLTTSCG NTLTCYLKAS 300
AACRAAKLQD CTMLVCGDDL VVICESAGTQ EDAASLRAFT EAMTRYSAPP 350
GDPPQPEYDL ELITSCSSNV SVAHDASGKR VYYLTRDPTT PLARAAWETA 400
RHTPVNSWLG NIIMYAPTLW ARMILMTHFF SILLAQEQLE KALDCQIYGA 450
CYSIEPLDLP QIIQRLHGLS AFSLHSYSPG EINRVASCLR KLGVPPLRVW 500
RHRARSVRAR LLSQGGRAAT CGKYLFNWAV RTKLKLTPIP AASQLDLSSW 550
FVAGYSGGDI YHSLSRARPR WFMWCLLLLS VGVGIYLLPN R 591
Length:591
Mass (Da):65,754
Last modified:January 1, 1998 - v1
Checksum:i6FA9C2F970260349
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97730 Genomic RNA. Translation: CAB10747.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97730 Genomic RNA. Translation: CAB10747.1 .

3D structure databases

ProteinModelPortali O39930.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

euHCVdbi Z97730.

Miscellaneous databases

EvolutionaryTracei O39930.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity."
    Lohmann V., Korner F., Herian U., Bartenschlager R.
    J. Virol. 71:8416-8428(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO39930_9HEPC
AccessioniPrimary (citable) accession number: O39930
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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