O39914 (O39914_9HEPC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Non-structural protein 4a/b EMBL AAB62970.2

Gene names

Name:

NS4a/b EMBL AAB62970.2

Organism

Hepatitis C virus EMBL AAB62970.2

Taxonomic identifier

11103 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Hepacivirus

Protein attributes

Sequence length	88 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 2A4Q PDB 1A1R
Gene Ontology (GO)
Biological_process	viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	virion part Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB62970.2
	Non-terminal residue	88	1	EMBL AAB62970.2

Sequences

	Sequence		Length	Mass (Da)
	O39914 [UniParc]. Last modified June 1, 2002. Version 2. Checksum: BF7B5198B317B6E0	FASTA	88	9,750
	10 20 30 40 50 60 YCLTTGSVVI VGRIILSGKP AIIPDREVLY QAFDEMEECA SHLPYIEHGM QLAEQFKQKA 70 80 LGLLQTATKQ AEAAAPVVES KWRALETF

References

[1]	"Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide." Kim J.L., Morgenstern K.A., Lin C., Fox T., Dwyer M.D., Landro J.A., Chambers S.P., Markland W., Lepre C.A., O'Malley E.T., Harbeson S.L., Rice C.M., Murcko M.A., Caron P.R., Thomson J.A. Cell 87:343-355(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 6-24.
[2]	"Sequence analysis of hepatitis C virus variants producing discrepant results with two different genotyping assays." Prescott L.E., Berger A., Pawlotsky J.M., Conjeevaram P., Pike I., Simmonds P. J. Med. Virol. 53:237-244(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease." Chen K.X., Njoroge F.G., Prongay A., Pichardo J., Madison V., Girijavallabhan V. Bioorg. Med. Chem. Lett. 15:4475-4478(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 6-24.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF007519 Genomic RNA. Translation: AAB62970.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A1R	X-ray	2.50	C/D	6-24	[»]
2A4Q	X-ray	2.45	B/D	6-24	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

euHCVdb

AF007519.

Family and domain databases

InterPro

IPR000745. HCV_NS4a.
[Graphical view]

Pfam

PF01006. HCV_NS4a. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O39914.

Entry information

Entry name

O39914_9HEPC

Accession

Primary (citable) accession number: O39914

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)