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O39914 (O39914_9HEPC) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:NS4a/b EMBL AAB62970.2
OrganismHepatitis C virus EMBL AAB62970.2
Taxonomic identifier11103 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Protein attributes

Sequence length88 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Technical term3D-structure PDB 1N1L PDB 2A4Q PDB 1A1R PDB 1RGQ PDB 1RTL
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentvirion

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAB62970.2
Non-terminal residue881 EMBL AAB62970.2

Sequences

Sequence LengthMass (Da)Tools
O39914 [UniParc].

Last modified June 1, 2002. Version 2.
Checksum: BF7B5198B317B6E0

FASTA889,750
        10         20         30         40         50         60 
YCLTTGSVVI VGRIILSGKP AIIPDREVLY QAFDEMEECA SHLPYIEHGM QLAEQFKQKA 

        70         80 
LGLLQTATKQ AEAAAPVVES KWRALETF 

« Hide

References

[1]"Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide."
Kim J.L., Morgenstern K.A., Lin C., Fox T., Dwyer M.D., Landro J.A., Chambers S.P., Markland W., Lepre C.A., O'Malley E.T., Harbeson S.L., Rice C.M., Murcko M.A., Caron P.R., Thomson J.A.
Cell 87:343-355(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 6-24.
[2]"Sequence analysis of hepatitis C virus variants producing discrepant results with two different genotyping assays."
Prescott L.E., Berger A., Pawlotsky J.M., Conjeevaram P., Pike I., Simmonds P.
J. Med. Virol. 53:237-244(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents."
Andrews D.M., Chaignot H., Coomber B.A., Good A.C., Hind S.L., Johnson M.R., Jones P.S., Mills G., Robinson J.E., Skarzynski T., Slater M.J., Somers D.O.
Org. Lett. 4:4479-4482(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 6-24.
[4]"Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease."
Slater M.J., Amphlett E.M., Andrews D.M., Bamborough P., Carey S.J., Johnson M.R., Jones P.S., Mills G., Parry N.R., Somers D.O., Stewart A.J., Skarzynski T.
Org. Lett. 5:4627-4630(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 6-24.
[5]"Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure."
Liu Y., Stoll V.S., Richardson P.L., Saldivar A., Klaus J.L., Molla A., Kohlbrenner W., Kati W.M.
Arch. Biochem. Biophys. 421:207-216(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 6-24.
[6]"Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease."
Chen K.X., Njoroge F.G., Prongay A., Pichardo J., Madison V., Girijavallabhan V.
Bioorg. Med. Chem. Lett. 15:4475-4478(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 6-24.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007519 Genomic RNA. Translation: AAB62970.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A1RX-ray2.50C/D6-24[»]
1N1LX-ray2.60C/D6-24[»]
1RGQX-ray2.90C/D6-24[»]
1RTLX-ray2.75C/D6-24[»]
2A4QX-ray2.45B/D6-24[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

euHCVdbAF007519.

Family and domain databases

InterProIPR000745. HCV_NS4a.
[Graphical view]
PfamPF01006. HCV_NS4a. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO39914.

Entry information

Entry nameO39914_9HEPC
AccessionPrimary (citable) accession number: O39914
Entry history
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: June 1, 2002
Last modified: December 11, 2013
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)