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O39914

- O39914_9HEPC

UniProt

O39914 - O39914_9HEPC

Protein
Submitted name:

Non-structural protein 4a/b

Gene

NS4a/b

Organism
Hepatitis C virus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. viral process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Non-structural protein 4a/bImported
    Gene namesi
    Name:NS4a/bImported
    OrganismiHepatitis C virusImported
    Taxonomic identifieri11103 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

    Subcellular locationi

    GO - Cellular componenti

    1. virion Source: InterPro

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A1RX-ray2.50C/D6-24[»]
    1N1LX-ray2.60C/D6-24[»]
    1RGQX-ray2.90C/D6-24[»]
    1RTLX-ray2.75C/D6-24[»]
    2A4QX-ray2.45B/D6-24[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO39914.

    Family & Domainsi

    Family and domain databases

    InterProiIPR000745. HCV_NS4a.
    [Graphical view]
    PfamiPF01006. HCV_NS4a. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O39914-1 [UniParc]FASTAAdd to Basket

    « Hide

    YCLTTGSVVI VGRIILSGKP AIIPDREVLY QAFDEMEECA SHLPYIEHGM   50
    QLAEQFKQKA LGLLQTATKQ AEAAAPVVES KWRALETF 88
    Length:88
    Mass (Da):9,750
    Last modified:June 1, 2002 - v2
    Checksum:iBF7B5198B317B6E0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei88 – 881Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007519 Genomic RNA. Translation: AAB62970.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007519 Genomic RNA. Translation: AAB62970.2 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A1R X-ray 2.50 C/D 6-24 [» ]
    1N1L X-ray 2.60 C/D 6-24 [» ]
    1RGQ X-ray 2.90 C/D 6-24 [» ]
    1RTL X-ray 2.75 C/D 6-24 [» ]
    2A4Q X-ray 2.45 B/D 6-24 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    euHCVdbi AF007519.

    Miscellaneous databases

    EvolutionaryTracei O39914.

    Family and domain databases

    InterProi IPR000745. HCV_NS4a.
    [Graphical view ]
    Pfami PF01006. HCV_NS4a. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide."
      Kim J.L., Morgenstern K.A., Lin C., Fox T., Dwyer M.D., Landro J.A., Chambers S.P., Markland W., Lepre C.A., O'Malley E.T., Harbeson S.L., Rice C.M., Murcko M.A., Caron P.R., Thomson J.A.
      Cell 87:343-355(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 6-24.
    2. "Sequence analysis of hepatitis C virus variants producing discrepant results with two different genotyping assays."
      Prescott L.E., Berger A., Pawlotsky J.M., Conjeevaram P., Pike I., Simmonds P.
      J. Med. Virol. 53:237-244(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents."
      Andrews D.M., Chaignot H., Coomber B.A., Good A.C., Hind S.L., Johnson M.R., Jones P.S., Mills G., Robinson J.E., Skarzynski T., Slater M.J., Somers D.O.
      Org. Lett. 4:4479-4482(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 6-24.
    4. "Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease."
      Slater M.J., Amphlett E.M., Andrews D.M., Bamborough P., Carey S.J., Johnson M.R., Jones P.S., Mills G., Parry N.R., Somers D.O., Stewart A.J., Skarzynski T.
      Org. Lett. 5:4627-4630(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 6-24.
    5. "Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure."
      Liu Y., Stoll V.S., Richardson P.L., Saldivar A., Klaus J.L., Molla A., Kohlbrenner W., Kati W.M.
      Arch. Biochem. Biophys. 421:207-216(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 6-24.
    6. "Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease."
      Chen K.X., Njoroge F.G., Prongay A., Pichardo J., Madison V., Girijavallabhan V.
      Bioorg. Med. Chem. Lett. 15:4475-4478(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 6-24.

    Entry informationi

    Entry nameiO39914_9HEPC
    AccessioniPrimary (citable) accession number: O39914
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3