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O39822 (NSP1_ROTEL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (isolate Equine/United Kingdom/L338/1988 G13-P12[18]-I6-Rx-Cx-M6-A6-Nx-Tx-Ex-Hx) (RV-A)
Taxonomic identifier36441 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Non-structural protein 1
PRO_0000369072

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region314 – 492179Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
O39822 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5DF0703BA4754C82

FASTA49258,174
        10         20         30         40         50         60 
MATFKDACFH YRKITKINRE LLKIGANSIW TPVRSDKIKG WCIECCQLTE LVFCSGCSLA 

        70         80         90        100        110        120 
HVCQWCVRNK RCFLDSQPHL LKLRTFEAPI TKEKLQCVIS MYNMLFPINE NIINRFKKNV 

       130        140        150        160        170        180 
KQKKCRNEFN ATWYNQLLLP ITLNAAVFKF QSRIVYVFGF YEGTTACGYL PYRMVNCIDI 

       190        200        210        220        230        240 
YDRLLLDSVN FDRMSALPSD LQALYAQKYF KISRLPSMKL RQVYYSDFTK QNLITKYRTK 

       250        260        270        280        290        300 
TRITHRNVSK INWDTDIELH NDLMHNKHRI LTALTTAEEK QFEVHDVNLG RIKADMFELG 

       310        320        330        340        350        360 
HHCKPNYISS NHWQPASRVS LCRWCNIKYA FRNMDWRMES MYNELMSFIQ SCYKSNANVD 

       370        380        390        400        410        420 
HCSSIESVYP MVRNVFWHST TKYIDETLEK LFNMMNPVNI DNQKVISFHW QIDLSLYLHI 

       430        440        450        460        470        480 
KMILKTEALP FMLKVHEFQS IVKGIINQWC DFSKVSELPI CVESTDTLLR MYEQGELSEE 

       490 
YELLISDSDG DE 

« Hide

References

[1]"Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains."
Kojima K., Taniguchi K., Kobayashi N.
Arch. Virol. 141:1-12(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38158 Genomic RNA. Translation: BAA20549.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTEL
AccessionPrimary (citable) accession number: O39822
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families