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Protein

Genome polyprotein

Gene
N/A
Organism
Sweet potato feathery mottle virus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.SAAS annotation

Catalytic activityi

Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, ProteaseSAAS annotation, RNA-directed RNA polymeraseSAAS annotation, Suppressor of RNA silencingSAAS annotation, Transferase

Keywords - Biological processi

Viral RNA replicationSAAS annotation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiC06.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiSweet potato feathery mottle virusImported
Taxonomic identifieri12844 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePotyviridaePotyvirus

Subcellular locationi

  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Virion

Structurei

3D structure databases

ProteinModelPortaliO39734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1000 – 1122Peptidase C6InterPro annotationAdd BLAST123
Domaini1598 – 1750Helicase ATP-bindingInterPro annotationAdd BLAST153
Domaini1769 – 1928Helicase C-terminalInterPro annotationAdd BLAST160
Domaini2415 – 2633Peptidase C4InterPro annotationAdd BLAST219
Domaini2899 – 3023RdRp catalyticInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the potyviridae genome polyprotein family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR001456. HC-pro.
IPR031159. HC_PRO_CPD_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002540. Pept_S30_P1_potyvir.
IPR009003. Peptidase_S1_PA.
IPR001592. Poty_coat.
IPR001730. Potyv_NIa-pro_dom.
IPR013648. PP_Potyviridae.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF07652. Flavi_DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00863. Peptidase_C4. 1 hit.
PF00851. Peptidase_C6. 1 hit.
PF01577. Peptidase_S30. 1 hit.
PF00767. Poty_coat. 1 hit.
PF08440. Poty_PP. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00966. NIAPOTYPTASE.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51744. HC_PRO_CPD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51436. POTYVIRUS_NIA_PRO. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O39734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVMASAKP AGKRKLTWKE CCNKWGRAAM EQQQQQQSKK TVHLGRDHLA
60 70 80 90 100
AYLLAFVPET EWHKYYYGSR GGPSPALLIL KGAIEHGEVY KWESELTFCA
110 120 130 140 150
ECDDVLDGHN CDSCGHRHIK RDDNIADNMN AIARALGGYD AYYASNWAVY
160 170 180 190 200
ETAKYELDQV APTAGMLYKQ AKEAEKLLGK RPTRREIQEV EDLWAEYEEA
210 220 230 240 250
AAREAAEASE ASNGHATSEV ANKNAYLSDG EDDEAFPPLV VTVEKVVPAT
260 270 280 290 300
TIIESTPEVG KTIEVQTPLE PVPEVLAATT FVEATIDGKD APTGSIQFGT
310 320 330 340 350
IVCELEPTKA SEAEIAKEPT TGFFFGTIPA IVPLPTIPLL KLESTIVEPI
360 370 380 390 400
ATPTVVVTSS EIVKVPIATP TEVEKASKAP LPKHLYPWTA KTQTPGKVHH
410 420 430 440 450
KMVRKWVQKT QQAAAEKEKL VWKKLDEQLA TRNEIRKDLK VKWRWGLYRL
460 470 480 490 500
VKKTRKDNQR QRRQRRMEKE QQLLMAMPPQ ALTGISIAGG PSASLEMTPT
510 520 530 540 550
PNGKISCTPS MKKKKTLKSP RLTQEKIHEL TQAVLKIACR KRMNIELVDK
560 570 580 590 600
KSTKGQYKKF QGANYLFLHL KHMEGLRESV DLRIHTTTQN LVLQAAKVGA
610 620 630 640 650
WKRTVKTTML SKGSSGLVLN PDKLLGPRGH APHGMLVVRG ALRGVLYDAR
660 670 680 690 700
MKLGRSVLPY IIQYSSTMER FLSGFDNKFK QIRQTDLNHV CESSYDAEQA
710 720 730 740 750
GSVAAISHHM LYPMGRTTCK SCINNVEDMS RDEWCEYVRS FISRNKILCQ
760 770 780 790 800
SEYKNFVHLP QIMDFLSDSL VNTNKNLKAF NEIQNLIGDR TDAPFTSVCE
810 820 830 840 850
VNKVLVKGGR AKPDELIKAS ENLLEVARYL KNRTENIKKG SLQSFRNKIS
860 870 880 890 900
QKSSVNLALM CDNQLDKNGN LIWGERGYHS KRFFANYFDV IDPSQGYEKY
910 920 930 940 950
VIRENPNGSR KLAIGKLIVS TNFSVFREQM KGEPIQKQKL DNHCTSLRDG
960 970 980 990 1000
NFVYPCCCVT LDDGQPLESE FKLPTKNHLV IGNSGDPKYV DMPPEISKKM
1010 1020 1030 1040 1050
YIAKDGYCYV NIFLAMLVNV NEAEAKDFTK QVRDVLMEKL GKWPTMFDVA
1060 1070 1080 1090 1100
TACAFMSVFY PETRNAELPR ILVDHSTKTM HVVDSFGSLS TGYHVLKANT
1110 1120 1130 1140 1150
VSQLIQFSSS SLESEMKHYI VGGVTALPDV QERCIRTIIK GVYKPDVMYT
1160 1170 1180 1190 1200
ILSEDPYALL LSVMSPRILL ALLNSGSLDR SMEAWITEDQ EVAVIIGTLQ
1210 1220 1230 1240 1250
ELAKKVSTSR VLEKQLKVIE SQAHTLLFDP AFVRSRTPSF ALSQKIIRGL
1260 1270 1280 1290 1300
AEGRESNRVL YEQGHSIASY AASHELMEKI WDRLLKEEYE GLPWHGKCAQ
1310 1320 1330 1340 1350
IMRSSKRACG LLSIPTWPKI GALSDRATDL CTTLHTKSVT FKNTCRNGVV
1360 1370 1380 1390 1400
QRIADAHIKC VRTIMRTSLA AIKFAIPDVL KFVNMLLVIN LLLQIAKVAR
1410 1420 1430 1440 1450
DMSTKHRQAQ IDLNAYLFDQ EIDKVNVIYD AYCLKIGGEP TMDEFLRHVE
1460 1470 1480 1490 1500
YINPTLSGTA KWLCYTADME VEHQGKSRKE MQYERIIAFV SLLLMIVDSE
1510 1520 1530 1540 1550
KSDCVYKILQ KLKGLMGTIN NDVYHQSLDD ITNVLEEKNL TVDFELQSGE
1560 1570 1580 1590 1600
HPTNPCTDST FDEWWRRQIE TNNTITHYRT EGVFIEFTRS NAVSVVNNIA
1610 1620 1630 1640 1650
TIDAKDILIR GAVGSGKSTG LPFYLSRKGR VLLLEPTRPL AENVHRQLGG
1660 1670 1680 1690 1700
EPFMVQATLR MRGLTVFGSH PINIMTTGFA FHYYANNPEQ IGEYDFIMFD
1710 1720 1730 1740 1750
ECHVHDAQAM AFRCLLKEHE FKGKILKTSA TPPGREVEFT TQYPVQIKVE
1760 1770 1780 1790 1800
ERLSFKAFVE AQGTGSNADV VTIADNILVY VASYNEVDEL SRMLVEANYK
1810 1820 1830 1840 1850
VTKVDGRTMK VGNVEIQTCG SPQKKHFIVA TNIIENGVTL DIEAVVDFGT
1860 1870 1880 1890 1900
KVTAYLDVDL RALHMSKGPI SYGERIQRLG RVGRNKAGVA LRIGFTEKGL
1910 1920 1930 1940 1950
TEIPQTTATE AAFLCFAYGL PVMTPNVSTS LLSTCTVKQA RTMLQFELTP
1960 1970 1980 1990 2000
FYMVNMVRYD GSMHPAIHSI LKKYKLRDAE TDLNKMAIPN RGVTGWLSVG
2010 2020 2030 2040 2050
EYVKSGKRMD IDDSVRIPFL NPSMPERLHV DIWDAITKYK HEAGFGRISC
2060 2070 2080 2090 2100
INSCKVAYTL QTDLYAIPRT IKIIDALIAD EMRKKEHYKT ITGRTVSSSS
2110 2120 2130 2140 2150
FTLNSIATLW RNRYAQDYTS ENIAVLSSVR SQLLEFENLS VDSSFNSMGE
2160 2170 2180 2190 2200
AALRAYVRET GATSCVLHQT KDSLSKHLRL KGVWNKSVIT QDLFILAGVF
2210 2220 2230 2240 2250
AGGLWMIMAG LKESFDQTVQ HQGREKRQMQ KLKFRKARDN KLGFEVHADD
2260 2270 2280 2290 2300
GTIEHFFGSA YTKKGKQKGK VTGMGSKNRK FINMYGFDPT EYSFVRFVDP
2310 2320 2330 2340 2350
LTGAVIDDSP YTDILLVQER IGEARLNAIK EDELSREKVA QNPGIHAYYI
2360 2370 2380 2390 2400
NEITNAALKV DLTPHNPLLA CERHSTIAGY PEYEGVLRQT GHPIKMTLND
2410 2420 2430 2440 2450
VPKSPEETSL VGHESKSLFR GLRDYNPIAS VICHLVNEAD GRTSDCFGIG
2460 2470 2480 2490 2500
YGGLIVTNRH LFKRNNGTLT IRSRHGEFVI KNTTQLGMKP CADRDILIIR
2510 2520 2530 2540 2550
MPKDIPPFPQ RLKFRVPKEN ERICLVGSNF QDKSITSTIS ETSVTCHVPN
2560 2570 2580 2590 2600
SHFWKHWIDT KDGHCGLPLV STTDGALLGV HSLSNLTNTQ NFFASFPENF
2610 2620 2630 2640 2650
EVDYLKTPEA MDWIKKWSYN PDEICWGTLE LKTGQPIAPF KVSKLITDLE
2660 2670 2680 2690 2700
GIQVYAQTRS DRWVQDRLYG NLKAVGQCPA QLVTKHVVKG KCMLFDLYLQ
2710 2720 2730 2740 2750
QDQSEKEYFK PLMGAYGKSR LNKEAYNKDL FKYATQIQAG DVQVDMFELA
2760 2770 2780 2790 2800
ERSVVSMLTA KGFEKCNYIT DPEEILKALN MKAAVGAMYS GKKKDYFEGM
2810 2820 2830 2840 2850
SDHDVEDHLF HSCKRLFMGY KGLWNGSLKA ELRPMEKVEL NKTRTFTAAP
2860 2870 2880 2890 2900
LDTLLGGKVC VDDFNNMFYN HHLKCPWTVG ITKFYQGWDR LLTSLPEGWI
2910 2920 2930 2940 2950
YCDADGSQFD SSLSPYLINS VLNIRREFME DWDVGDQMLR NLYTEIVYTP
2960 2970 2980 2990 3000
ILTPDGTIVK KFKGNNSGQP STVVDNTLMV VLAVHYTLLK LGIQESEFDE
3010 3020 3030 3040 3050
CCVFFANGDD LLLAMRPDTA HLLDKFSECF SELGLNYDFS SRTSNKEELW
3060 3070 3080 3090 3100
FMSHRGLKRD GIFIPKLEPE RIVSILEWDR SHEPIHRLEA ICAAMVESWG
3110 3120 3130 3140 3150
YDELLHHIRK FYAWVLDQAP YNELARSGKA PYIAETALKA LYTGVQPSAS
3160 3170 3180 3190 3200
ELSAYAKVLN EMYDDSVLQE NELEVYHQSS ERTEFKDAGA NPPAPKPQNI
3210 3220 3230 3240 3250
PPPPTITEVT DPEDPKQAAL RAARAKQPAT IPESYGRDTS KEKESIVGAS
3260 3270 3280 3290 3300
SKGARDKDVN VGTVGTFVVP RVKMNANKKR QPMVNGRAII NFQHLSTYEP
3310 3320 3330 3340 3350
EQFEVANTRS TQEQFQAWYE GVKGDYGVDD TGMGILLNGL MVWCIENGTS
3360 3370 3380 3390 3400
PNINGVWTMM DGDEQVTYPI KPLLDHAVPT FRQIMTHFSD VAEAYIEMRN
3410 3420 3430 3440 3450
RTKAYMPRYG LQRNLTDMSL ARYAFDFYEL HSTTPARAKE AHLQMKAAAL
3460 3470 3480 3490
KNAKNRLFGL DGNVSTQEED TERHTTTDVT RNIHNLLGMR GVQ
Length:3,493
Mass (Da):393,821
Last modified:January 1, 1998 - v1
Checksum:i302EC864FE70B8C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86371 Genomic RNA. Translation: BAA22702.1.
RefSeqiNP_045216.1. NC_001841.1.

Genome annotation databases

GeneIDi1724897.
KEGGivg:1724897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86371 Genomic RNA. Translation: BAA22702.1.
RefSeqiNP_045216.1. NC_001841.1.

3D structure databases

ProteinModelPortaliO39734.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC06.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1724897.
KEGGivg:1724897.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR001456. HC-pro.
IPR031159. HC_PRO_CPD_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002540. Pept_S30_P1_potyvir.
IPR009003. Peptidase_S1_PA.
IPR001592. Poty_coat.
IPR001730. Potyv_NIa-pro_dom.
IPR013648. PP_Potyviridae.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF07652. Flavi_DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00863. Peptidase_C4. 1 hit.
PF00851. Peptidase_C6. 1 hit.
PF01577. Peptidase_S30. 1 hit.
PF00767. Poty_coat. 1 hit.
PF08440. Poty_PP. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00966. NIAPOTYPTASE.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51744. HC_PRO_CPD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51436. POTYVIRUS_NIA_PRO. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO39734_9POTV
AccessioniPrimary (citable) accession number: O39734
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.