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Protein

Genome polyprotein

Gene
N/A
Organism
Foot-and-mouth disease virus - type O
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Ion channel, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase, Viral ion channelSAAS annotation

Keywords - Biological processi

Host-virus interaction, Ion transport, Transport, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiFoot-and-mouth disease virus - type OImported
Taxonomic identifieri12118 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeAphthovirus

Subcellular locationi

  • Host cytoplasmic vesicle membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Cytoplasmic side SAAS annotation
  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host cytoplasmSAAS annotation, Host cytoplasmic vesicleSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

Structurei

3D structure databases

ProteinModelPortaliO39176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1187 – 1351165SF3 helicaseInterPro annotationAdd
BLAST
Domaini2084 – 2202119RdRp catalyticInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the picornaviruses polyprotein family.SAAS annotation
Contains RdRp catalytic domain.SAAS annotation
Contains SF3 helicase domain.SAAS annotation

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProiIPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR008739. Peptidase_C28.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR009003. Peptidase_S1_PA.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF05408. Peptidase_C28. 1 hit.
PF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O39176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTDCFIAL LYVLREIKAL FLSRTQGKME FTLYNGEKKV FHSRPNNHDN
60 70 80 90 100
CWLNAILQLF RYVDEPFLEW VYDSPENLTL EAINKLEEIT GLELHEGGPP
110 120 130 140 150
ALVVWNIKHL LYTGIGTASR PSEVCMVDGT DMCLADFHAG IFLKGQDHAV
160 170 180 190 200
FACVTSNGWY AIDDEDFYPW TPNPADVLVF VPYDQEPFNA EWKAKVQKRL
210 220 230 240 250
RGAGQSSPTT GSQNQSGNTG SIINNYYMQQ YQNSMDPQLG DNAISGGSNE
260 270 280 290 300
GFTDTTSTHT NNTQNNDWFS KLANTAFIGL FGALLADKKT EETTLLEDRI
310 320 330 340 350
LTTRNGHTTS TTQSSVGVTY GYATAEDFVS GPNTSGLETR VVQAERFFKT
360 370 380 390 400
HLFDWVTSDP FGRCHLLELP TDHKGVYGSL TDSYAYMRNG WDVEVTAVGN
410 420 430 440 450
QFNGGCLLVA MVPELCSISK RELYQLTLFP HQFINPRTNM TAHITVPYLG
460 470 480 490 500
VNRYDQYKVH KPWTLVVMVV APLTVNNEGA PQIKVYANIA PTNVHVAGEL
510 520 530 540 550
PSKEGIFPVA CSDGYGGLVT TDPKTADPVY GKVFNPPRNL LPGRFTNLLD
560 570 580 590 600
VAEACPTFLH FDGDVPYVTT KTDSDRVLAR FDLSLAAKHM SNTFLAGLAQ
610 620 630 640 650
YYTQYSGTIN LHFMFTGPTD AKARYMVAYA PPGMEPPKTP EAAAHCIHAE
660 670 680 690 700
WDTGLNSKFT FSIPYLSAAD YPYTASDVAE TTNVQGWVCL FQITHGKADG
710 720 730 740 750
DALVVLASAG KDFDLRLPVD AEPQTTSAGE SADPVTATVE NYGGETQVQR
760 770 780 790 800
RQDTDIAFIL DRFVKVKPKE QVNVLDLMQI PAHTLVGALL RTATYYFSDL
810 820 830 840 850
ELAVKHEGDL TWVPNGAPET ALDNTTNPTA YHKEPLTRLA LPYTAPHRVL
860 870 880 890 900
ATVYNGSSKY GDTSTNNVRG DLQVLAQKAE RTLPTSFNFG AIKATRVTEL
910 920 930 940 950
LYRMKRAETY CPRPLLAIQP SDARHKQRIV APAKQLLNFD LLKLAGDVES
960 970 980 990 1000
NPGPFFFSDV RANFTKLVDT VNQMQEDMST KHGPDFNRLV SAFENWRWVK
1010 1020 1030 1040 1050
AIRTGLDEAK PWYKLIKLLS RLSCMAAVAA RSKDPVLVAI MLGDTGLEIL
1060 1070 1080 1090 1100
DSTFVVKKIS DSLSSLFHVA APAFSFEPDL LAGLVKVASS FFQSTPEDLE
1110 1120 1130 1140 1150
RAEKQLKARD INDIFAVLKN GEWLVKLILA IRDWIKAWIA SEEKFVTMTD
1160 1170 1180 1190 1200
LVPGILESQR DLNDPGKYKE AKEWLDNARQ ACLKSGNVHI ANLCKVVAPA
1210 1220 1230 1240 1250
PSKSRPEPVV VCLRGKSGTR KSILANVLAQ AISTHFTGRT DSVWYCPPDP
1260 1270 1280 1290 1300
DHFDGYNQQT VVVMDDLGQN PDGKDFKYFA QMVSTTGFIP PMASLEDKGK
1310 1320 1330 1340 1350
PFNSKVIIAT TNLYSGFTPK TMVCPDALNR RFHFDIDVSA KDGYKINNKL
1360 1370 1380 1390 1400
DIVKALEDTH ANPVAMFQYD CALLNGMAVE MKRMQQDMFK PQPPFQNIYQ
1410 1420 1430 1440 1450
LVQEVIERVE LHEKVSSHPI FKQISIPSQK SVLYFLIEKG QHEAAIEFFE
1460 1470 1480 1490 1500
GMVHDSIKEE LRPLIQQTSF VKRAFKRLKE NFEVVALCLT LLANIVIMLR
1510 1520 1530 1540 1550
QARKRYQSVD DPLDGDVALG DAEKNPLETS AASAVGFRER SPTEQGTRED
1560 1570 1580 1590 1600
ANAEPVVFGR EQPRAEGPYA GPLERQKPLK VKAELPQQEG PYAGPMERQK
1610 1620 1630 1640 1650
PLKVKAKAPV VKEGPYEGPV KKPVALKVKA KNLIVTESGA PPTDLQKMVM
1660 1670 1680 1690 1700
GNTKPVELIL DGKTVAICCA TGVFGTAYLV PRHLFAEKYD KIMLDGRALT
1710 1720 1730 1740 1750
DSDYRVFEFE IKVKGQDMLS DAALMVLHRG NRVRDITKHF RDVARMKKGT
1760 1770 1780 1790 1800
PVVGVINNAD VGRLIFSGVA LTYKDIVVCM DGDTMPGLFA YRASTKAGYC
1810 1820 1830 1840 1850
GGAVLAKDGA ETFIVGTHSA GGNGIGYCSC VSRSMLLKMK AHIDPEPHHE
1860 1870 1880 1890 1900
GLIVDTRDVE ERVHVMRKTK LAPTVAHGVF NPEFGPAALS NKDPRLNEGV
1910 1920 1930 1940 1950
VLDDVIFSKH KGDTRMSEED KALFRRCAAD YASRLHSVLG TANAPLSVYE
1960 1970 1980 1990 2000
AIKGVDGLDA MEPDTRPGLP WALQGKRRGV LIDFENGTVG PEVEAALKLM
2010 2020 2030 2040 2050
ESREYKFVCQ TFLKDEIRPL EKVRAGKTRI VDVLPVEHIL YTRMMIGRFC
2060 2070 2080 2090 2100
AQMHSNNGPQ IGSAVGCNPD VDWQRFGTHF AQYKNVWDVD YSAFDANHCS
2110 2120 2130 2140 2150
DAMNIMFEEV FRTEFGFHPN AEWILKTLVN TEHAYENKRI VVEGGMPSGC
2160 2170 2180 2190 2200
SATSIINTIL NNIYVLYALR RHYEGVELDT YTMISYGDDI VVASDYDLDF
2210 2220 2230 2240 2250
EALKPHFKSL GQTITPADKS DKGFVLGHSI TDVTFLKRHF HMDYGTGFYK
2260 2270 2280 2290 2300
PVMASKTLEA ILSFARRGTI QEKLISVAGL AVHSGPDEYR RLFEPFQGLF
2310 2320
EIPSYRSLYL RWVNAVCGDA
Length:2,320
Mass (Da):257,907
Last modified:May 1, 2000 - v2
Checksum:iE459C78E160FA8FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026168 Genomic RNA. Translation: AAB81991.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026168 Genomic RNA. Translation: AAB81991.2.

3D structure databases

ProteinModelPortaliO39176.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.120.20. 3 hits.
4.10.90.10. 1 hit.
InterProiIPR015031. Capsid_VP4_Picornavir.
IPR004080. FMDV_VP1_coat.
IPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR000605. Helicase_SF3_ssDNA/RNA_vir.
IPR014759. Helicase_SF3_ssRNA_vir.
IPR027417. P-loop_NTPase.
IPR008739. Peptidase_C28.
IPR000199. Peptidase_C3A/C3B_picornavir.
IPR009003. Peptidase_S1_PA.
IPR001676. Picornavirus_capsid.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF05408. Peptidase_C28. 1 hit.
PF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
PF00073. Rhv. 3 hits.
PF00910. RNA_helicase. 1 hit.
PF08935. VP4_2. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PR01542. FMDVP1COAT.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
PS51218. SF3_HELICASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of foot-and-mouth disease virus from a Taiwanese strain."
    Liu S.-T., Wu W.-Y.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Chu-PeiImported.
  2. "Molecular epidemiological studies on foot-and-mouth disease type O Taiwan viruses from the 1997 epidemic."
    Tsai C., Pan C., Liu M., Lin Y., Chen C., Huang T., Cheng I., Jong M., Yang P.
    Vet. Microbiol. 74:207-216(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Chu-PeiImported.

Entry informationi

Entry nameiO39176_9PICO
AccessioniPrimary (citable) accession number: O39176
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.