ID   NTP1_HAEPV              Reviewed;         646 AA.
AC   O37319;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 45.
DE   RecName: Full=Nucleoside triphosphatase I;
DE            EC=3.6.1.15;
DE   AltName: Full=Nucleoside triphosphate phosphohydrolase I;
DE            Short=NPH I;
GN   Name=NPH1; ORFNames=F1L;
OS   Heliothis armigera entomopoxvirus (HaEPV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Entomopoxvirinae;
OC   Betaentomopoxvirus.
OX   NCBI_TaxID=10290;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=98062131; PubMed=9400959;
RA   Sriskantha A., Osborne R.J., Dall D.J.;
RT   "Mapping of the Heliothis armigera entomopoxvirus (HaEPV) genome, and
RT   analysis of genes encoding the HaEPV spheroidin and nucleoside
RT   triphosphate phosphohydrolase I proteins.";
RL   J. Gen. Virol. 78:3115-3123(1997).
CC   -!- FUNCTION: Serves two roles in transcription; it acts in concert
CC       with viral termination factor/capping enzyme to catalyze release
CC       of UUUUUNU-containing nascent RNA from the elongation complex, and
CC       it acts by itself as a polymerase elongation factor to facilitate
CC       readthrough of intrinsic pause sites (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- SIMILARITY: Belongs to the helicase family. NPH I subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
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DR   EMBL; AF019224; AAB96624.1; -; Genomic_DNA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR014001; DEAD-like_N.
DR   InterPro; IPR001650; DNA/RNA_helicase_C.
DR   InterPro; IPR014021; Helicase_SF1/SF2_ATP-bd.
DR   InterPro; IPR013676; NPHI_C.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF08469; NPHI_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Nucleotide-binding; Transcription.
FT   CHAIN         1    646       Nucleoside triphosphatase I.
FT                                /FTId=PRO_0000099102.
FT   DOMAIN       48    213       Helicase ATP-binding.
FT   DOMAIN      377    540       Helicase C-terminal.
FT   NP_BIND      61     68       ATP (By similarity).
FT   MOTIF       151    154       DEXH box.
SQ   SEQUENCE   646 AA;  75763 MW;  AA1B63287F8B8034 CRC64;
     MFTLDSIVGA HINYALDKTA HLPETITNNV SNVEITLKDY QYFVSRVFIG LKNLNSMLLF
     WDTGMGKTLT AVYIIKHIKE LFPRWIILIF IKKSLYIDPW LNTIRAFAPD ISNNIIFVYY
     DSSSSLDKFV NIYRSIENSL NKKNRLLIII DEVHKLISRS VKKDNSERNF TPTYKKLIKL
     ANYEGNKILC MSATPIYNNI DEFNNLIGLL RPNVMTFKEE YIINGKLINF KEIRDTLLGL
     CSYKRLIEAD SFTETNYVEG YAKKNVIYHN IIMSEEQSKL FNLAEKYDYK TELGGLKTMR
     RLVSSFAFYD LKIKGDLNNI EYNDMIKRKL AEFSEFTKTI NFSNNFIEKF KRDDLKNDIL
     LEDINNYNIL YQYSCKYIEA CRIILNSRGK VLLFEPLVNF EGIASLKYYF NCFNITYVEY
     SSKTLKTRDI EISEYNNYEN NDGKNIKVCI FSYAGSEGIS FKCVNDIIIL DMPWNESELK
     QIMGRSIRLN SHNDLPLENR YVNVHFIISY TNNRKSVDKE ILDIIKDKQS KINVVFDLLK
     SISIESIHNI HKYIEPVESE TIFDTIRKTR MREMNISNVI VKIKLYPIMY CKDYDRATIL
     KGLLNKENNI IYNEDTAVAK LTIENNKPVF IIVDDNLIYI ADDYYE
//