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Protein

Ankyrin repeat domain-containing protein A238L

Gene

Mal-047

Organism
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits activation of the NF-kappa-B transcription factor by preventing binding of NF-kappa-B subunits RELA and NFKB3 to DNA. Inhibits also the activity of the calcium/calmodulin-regulated phosphatase calcineurin (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host NF-kappa-B by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein A238L
Alternative name(s):
p28
Gene namesi
Ordered Locus Names:Mal-047
ORF Names:5EL
OrganismiAfrican swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
Taxonomic identifieri10500 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Phacochoerus aethiopicus (Warthog) [TaxID: 85517]
Phacochoerus africanus (Warthog) [TaxID: 41426]
Potamochoerus larvatus (Bushpig) [TaxID: 273792]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000000860 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003728381 – 239Ankyrin repeat domain-containing protein A238LAdd BLAST239

Interactioni

Subunit structurei

Interacts with host PPIA and PPP3CA. Interacts with host EP300; this interaction inhibits the association of host AP300 with host RELA, JUN and NFATC2 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60108N.

Structurei

Secondary structure

1239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi207 – 211Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F0ZX-ray1.70C200-239[»]
ProteinModelPortaliO36972.
SMRiO36972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati87 – 116ANK 2Add BLAST30
Repeati124 – 153ANK 3Add BLAST30
Repeati158 – 187ANK 4Add BLAST30

Domaini

The C-terminal region contains a docking motif P-x-I-x-I-T-x-[CS] required and sufficient for binding to calcineurin.By similarity

Sequence similaritiesi

Belongs to the asfivirus A238L family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

OrthoDBiVOG090000K6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
PfamiView protein in Pfam
PF00023. Ank. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 4 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.

Sequencei

Sequence statusi: Complete.

O36972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIGLFSVE AEHLFVEWVK KCIKKGDLTL FETLFNADPW IVNRCNKNKI
60 70 80 90 100
TVFMLICIYG RLDFLRFLFK QESYPGEIVN HYRRDKDGNS AWHYLAEKNN
110 120 130 140 150
HLLLEEVLDY FGKNGIRVCF PNFNGVTPIM KAAMRGRTLS VLSLLKYGAN
160 170 180 190 200
PNRKDYLKGF TTWDWAVFTG HADLVKTLNK GYQKPLFMHF PLYKLDVFHR
210 220 230
RFKKKPKIII TGCEDNVYEK LPEQNSNFLC VKKLNKYGK
Length:239
Mass (Da):28,080
Last modified:January 1, 1998 - v1
Checksum:iC6FA085308BF2CBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014479 Genomic DNA. Translation: AAB71361.1.
AY261361 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014479 Genomic DNA. Translation: AAB71361.1.
AY261361 Genomic DNA. No translation available.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F0ZX-ray1.70C200-239[»]
ProteinModelPortaliO36972.
SMRiO36972.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60108N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000K6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
PfamiView protein in Pfam
PF00023. Ank. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 4 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVF238_ASFM2
AccessioniPrimary (citable) accession number: O36972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 1, 1998
Last modified: February 15, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.