O36420 (UL31_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Virion egress protein 69

Alternative name(s):
Primary envelopment factor 69

Gene names

Name:

69

Organism

Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]

Taxonomic identifier

654901 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Macavirus › Alcelaphine herpesvirus 1

Virus host

Connochaetes taurinus (Brindled gnu) [TaxID: 9927]

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, protein 69/67 complex induces capsids budding and envelopment into the perinuclear space. Then 69/67 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network By similarity.
Subunit structure	Forms a complex with protein 67 By similarity.
Subcellular location	Host nucleus inner membrane. Note: Remains attached to the nucleus inner membrane through interaction with protein 67. Localizes also at the transient membrane of perinuclear virions By similarity.
Sequence similarities	Belongs to the herpesviridae UL31 family.

Ontologies

Keywords
Cellular component	Host membrane Host nucleus Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nuclear inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Virion egress protein 69		PRO_0000405765
Regions
	Transmembrane	180 – 202	23	Helical; Potential
	Compositional bias	33 – 36	4	Poly-Lys

Sequences

	Sequence		Length	Mass (Da)
	O36420 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 401D13C92D1D57D9	FASTA	280	31,415
	10 20 30 40 50 60 MHKIQKMSCT PSVRSRYTLK RKRLNSAKSA TLKKKKVFLS NSEFFAGVST NYELGKDFLR 70 80 90 100 110 120 EMDTPICTSN TVFLPVKFSD VAPGRCLTLS PYGHSSVLGF HCQECKPDSS SGFTQAQQSA 130 140 150 160 170 180 ESNELLSVNL CFLNNVEKVV QHKAFYLSLL GHSMNTVKQS LGQPSLLYCY TVLKKFYPQI 190 200 210 220 230 240 FPIFTANGPM LTMYIIFTSL TLHVSEAVLR ILTDNVENHN LSADCYKGHY ILSIEPQALE 250 260 270 280 ESNLNVCVTK ICDLVAQLDF SDELKQEYVN GSTLIANFLN

References

[1]	"Primary structure of the alcelaphine herpesvirus 1 genome." Ensser A., Pflanz R., Fleckenstein B. J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF005370 Genomic DNA. Translation: AAC58117.1.
PIR	T03165.
RefSeq	NP_065569.1. NC_002531.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911772.
Phylogenomic databases
ProtClustDB	CLSP2509705.
Family and domain databases
InterPro	IPR021152. Herpes_UL31. [Graphical view]
Pfam	PF02718. Herpes_UL31. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL31_ALHV1

Accession

Primary (citable) accession number: O36420

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program