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O36414

- DEN_ALHV1

UniProt

O36414 - DEN_ALHV1

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Protein

Deneddylase

Gene
64
Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341 By similarity
Active sitei163 – 1631 By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Alternative name(s):
Ubiquitin thioesterase
Gene namesi
Name:64
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
ProteomesiUP000000941: Genome

Subcellular locationi

Virion tegument. Host cytoplasm. Host nucleus By similarity
Note: Tightly associated with the capsid By similarity.

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26062606DeneddylasePRO_0000405760Add
BLAST

Proteomic databases

PRIDEiO36414.

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 225212Peptidase C76Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1703 – 17086Poly-Pro
Compositional biasi2069 – 20724Poly-Ala
Compositional biasi2273 – 2397125Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O36414-1 [UniParc]FASTAAdd to Basket

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MAFQAQTDTG LQLLATASSH QGDCKYGPFA GSQCLSVCVY YLASSFMNNA     50
PVDSREGLDD VLLHGSTLDR LMRTHNFIPM NEFAQLSSVP KVLITHLWSC 100
AIETSPELYG LLSDECVVCA PFIMSLRKAL EMNYFEIPQY ILYICNGKSG 150
AIIIKNKTYF IFDPHCTSSR DTAAVYASAS ASSVVAYVGE ASREYTACHL 200
YFIPAESSDE PVNEYLLANY GIASALKRSG AYVNLKTLQT HAISESTQPI 250
APPVPAAPSG MQFFPTQASF PSSQSFVATS TPVPTKALKP TPSHQPSIPG 300
AASLKTALHM ATVKRKRIAI SPLHSNTESD DSETGKKNTP VKITKPNEAD 350
VGEVETFWLD DDISTKQMLS ETSSSEKNLP ESIFSSSDWD TDSLLSTHES 400
PPATPSLKSG QVNYTSTFSL DNEELGGSNL QLQDKTYKLD STTFENLPQL 450
LTSLEEHIEK VSKYPHKNDM PVIVDHSVNK CYREAVALYT IDSLLSHVIE 500
QGLISKPEHK SQALNILRYI AIWLNKLSIY TNQVQELINT ELYIPYIYQA 550
LFATKFDGKL EAMLIEKITK CFQTLHGTSL QDMKNLSKMI QASIKNTPYY 600
DKAVNVQEET ENLKSAVSLP YFITTEEELK KIQALAANLW KVIQDHNNSV 650
SHEDSEFHRA VNSVKNFLPI PSDIQPLDYT LSDKADYLGD TVQQLVASIT 700
QECQTISNHM LSSMQSNVSF SADIPDFYSL RGKICTTLNN IQTSKDHLGL 750
YNDKLQKARQ QLAYLGYEIS SITNSQWSTD YTEPVTPIPE LGEIQSQLKI 800
FNTNQQNQQM LQNILDEVES MLQAAKSEQT EQGLQKLAML LPSIEAYLEN 850
AGTLLGPEGN AQFDRLRKEI TDLIGSVDVM LAYVKNISAH TLATDAQTIS 900
NFPTDAKQQR VFQQALTQKV KDLFTQVNAS LKTDRPPTFT ENDMAALESL 950
AVMSNDSTLS TAAAFYTKIT LLLKSKPDCT VPLYDIAHLK SQLATANINS 1000
STKRSLYMLL AQLNKETVSK KGLEQTQAPA PKGPTADTPV TDSKLIQDSQ 1050
QNDRHQKEKP LKPKKPQAIS LPAVKDTTKH LKPSKPQNLS LPVSTNKAPV 1100
EESPESSPIE STSPSHSPVS SMESQNGSFS LESSEEELMD TFAVDDHELS 1150
DTDHHMDVDK TTTSVAMDDK PSTSPEPPSQ SLSAIVQQEE RLGEEQAWKK 1200
IQIAFKTLDF TDITYSDWVH VTGITQHHDL KVSETFGPTL ESLMSPLLQK 1250
LKKMTIGAAL SLTTYGQAFK WPSIDWMTPY KNNVLFYLST VRYPSLVDLA 1300
EQSRAEIDVL LQLRSSDALL KGTAGTYLES DSRNMLDIVS SIEDAASDYK 1350
LNVHTEVEKW THQVHNIVNT GDSLPPKPDV ILPSHLLNPA FEQTIASLNK 1400
DFRDYVYTVE KHLLAELSND FQLLKVLISE TENGFQAWEK ETANKLLQLI 1450
SHSLQNAPPE VRQYTVSHTD PLTLFDKLIH DSEVSSKLTY SEASAALHWV 1500
ESTCAHIATQ CQYPAVGAKL QAIIALVAKV KPKLESLVSL ENQANNTDDI 1550
NIIKQAISSL DPKRITGGTS KVQEWTQKVK DLEKLLADTE LEASVVQNIQ 1600
LLRHMALTAR STNLLANLKQ KTTSLYEKWV KEHKTGPTSP ITGTIKELDL 1650
YLTFKLKFIE YYETNQACIF STFALPASKI DAKDALTPLT PQSPVFDFNT 1700
SGPSPPPPIN FQQRLEAMCH LNYAPTQPIW LQVFPTVDNL SMDYIPIKNA 1750
SPLSLQVIFN NFIETYFVQA PQGPQKDTSQ YRGSTVLPNV LQAHFGTIAT 1800
HLINSHWNNI LENSTQALQS YTTVHSLHGT AKQNEFMAII VAVHGLLQSL 1850
STIYLDTPAN SSDIPVVLSF RATLEIILWI WPKIIFYFLK MKSFQSGVSF 1900
LQIMINRCLI NLTSAFVIQH ITNSLIMAGV PEPNGYLFCP KYWTQLEPQA 1950
YLWGDEKFLQ LCSNSQEKAR VCFFVCALES INPVVLGQLW RSLKPTFLPD 2000
VHTPYDFLKV LVEAAYKPAY DCQVVSKARV DETPPYSYGF PGNSVLRVES 2050
KTTKPQGVTT IPISGFEMAA AAILQKFNPV IYLSTKKPVF SNEFTGEIFV 2100
VSPLLDCTGN EEPFSSLLTA PLQPVSENTT LASLYTQLEK DIFRSQKLWL 2150
QQHLSSPNNL SHLKHPIVLL DSEKKLTGAY SLTNNAPPPQ LLNLRFAYDG 2200
KGLPNWPMEI LQASTLSYSH QQALEDKTKD WIIDIEDLDD SLCIQNMFSA 2250
YPPEIHSGPS RSDSEDSEDS LSPTSPTPHL PKAEFTPLPD SPKPPQDPKD 2300
KSTPNPPRPT TFPTPLLPCY PLSEAYATLP KPISIKPSAR VHFVVPPKSN 2350
LAADQLLRDF ESLSLQDRPE RPKDGPPDIN YLVPPHGSYI NLQPPNPRMA 2400
VIGTLRAADQ KSVFTPTRPA GVGSRAKWVS RQLPPHDFVE PVENGDPPGP 2450
PGSEERKYSI RQESYQDPTV SLLLRQPPII EAVRLFPDKS LTAAQMQQAF 2500
KQKQLHVCEK SHRKRLLSAP PTIAPNHLSI HEILADRASL VAPRPPFIPI 2550
DENLDIEPLF VQFIMEVSIE EAKNVLITFI KKIRQAVTHN AQLLASSIQR 2600
LAALYL 2606
Length:2,606
Mass (Da):290,017
Last modified:January 1, 1998 - v1
Checksum:i0D3604B55D673082
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58111.1.
PIRiT03159.
RefSeqiNP_065563.1. NC_002531.1.

Genome annotation databases

GeneIDi911802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58111.1 .
PIRi T03159.
RefSeqi NP_065563.1. NC_002531.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O36414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911802.

Family and domain databases

InterProi IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the alcelaphine herpesvirus 1 genome."
    Ensser A., Pflanz R., Fleckenstein B.
    J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDEN_ALHV1
AccessioniPrimary (citable) accession number: O36414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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