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O36411

- RIR1_ALHV1

UniProt

O36411 - RIR1_ALHV1

Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

61

Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei177 – 1771SubstrateBy similarity
    Sitei193 – 1931Important for hydrogen atom transferBy similarity
    Binding sitei223 – 2231Substrate; via amide nitrogenBy similarity
    Active sitei393 – 3931Proton acceptorBy similarity
    Active sitei395 – 3951Cysteine radical intermediateBy similarity
    Active sitei397 – 3971Proton acceptorBy similarity
    Sitei409 – 4091Important for hydrogen atom transferBy similarity
    Sitei726 – 7261Important for electron transferBy similarity
    Sitei727 – 7271Important for electron transferBy similarity
    Sitei776 – 7761Interacts with thioredoxin/glutaredoxinBy similarity
    Sitei779 – 7791Interacts with thioredoxin/glutaredoxinBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase large subunit
    Gene namesi
    Name:61
    OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
    Taxonomic identifieri654901 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
    Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
    ProteomesiUP000000941: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 780780Ribonucleoside-diphosphate reductase large subunitPRO_0000405696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi193 ↔ 409Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small chain.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO36411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni192 – 1932Substrate bindingBy similarity
    Regioni393 – 3975Substrate bindingBy similarity
    Regioni595 – 5995Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    IPR008926. RNR_R1-su_N.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    SUPFAMiSSF48168. SSF48168. 1 hit.
    TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
    PROSITEiPS00089. RIBORED_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O36411-1 [UniParc]FASTAAdd to Basket

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    MASAEATPQQ QIDQLKVNAG WDMKSNIKAG LLHHEEMEKK ATKTVTEYIE    50
    KFADVLEENV LRFLQDNAEM LELCIYMYEQ LPAYKAVKSR GILSAKRFYD 100
    TYVLRTADGS CYESVSHCFM RIAAFCTVQV LTNSALKITI LYLGRDKLFK 150
    DLPCSPTMDL FIYFFSPLSH QLVCCATPIM RSAGLRDANL ASCFLINPDL 200
    STEKSTTTAL LQELTMLLSA KSGVGCNVTS FGVDEKCIQS CVGLINSQVE 250
    FFNDQNPRPV SVAAYMEVWH SQIQEFLAVK LPENPSRCAS IYQGLCIPKL 300
    FFEKFIEDPG QNWYLFKPEK SGNLANLYGD EFRSEYERLV GIGCYADAIP 350
    IKSLMFLIIN TIIKTGSPYI IYKEACNEHH WKNMEGCAIA SANLCAEVIQ 400
    YPGADVSTCN LANVCLPMCL VTVSNDSHSP LEKTYCGNVI ESQAVSGVGF 450
    SMPILHAAVE VAVFLVNCAI AGGKCVTPGM ERGQRERSMG IGVHGLADVF 500
    AEMGYSYLDE RAARLDVEIF ENMYFRAVKT SNNICRLGGG RPFEGWGESK 550
    LRHGFFHWQG WEDVNLSIPI TEWEKLSRRC ISSGVYNSQF IALMPTVGSS 600
    LLTGFSESYY PYFANISSKV SSKEEVMKPN MTFWNRVSKE DLDTVRFFSG 650
    DVALFPEPLK EKYSLFLSAF DYCAEKQLAR ARLRAPFVDQ SQSHSFHLKE 700
    ENVVSARFLK DLILSGYTLG LKTIMYYCKV KKQSTMSSFQ CLRDQNKSEM 750
    TGNDQGVEPE SYIKCTAAGG ETSEACLHCQ 780
    Length:780
    Mass (Da):87,362
    Last modified:January 1, 1998 - v1
    Checksum:i0B4C197AB8D76DDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005370 Genomic DNA. Translation: AAC58108.1.
    PIRiT03156.
    RefSeqiNP_065560.1. NC_002531.1.

    Genome annotation databases

    GeneIDi911785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005370 Genomic DNA. Translation: AAC58108.1 .
    PIRi T03156.
    RefSeqi NP_065560.1. NC_002531.1.

    3D structure databases

    ProteinModelPortali O36411.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 911785.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    InterProi IPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    IPR008926. RNR_R1-su_N.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    SUPFAMi SSF48168. SSF48168. 1 hit.
    TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
    PROSITEi PS00089. RIBORED_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the alcelaphine herpesvirus 1 genome."
      Ensser A., Pflanz R., Fleckenstein B.
      J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR1_ALHV1
    AccessioniPrimary (citable) accession number: O36411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3