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O36411 (RIR1_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase large subunit

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase large subunit
Gene names
Name:61
OrganismAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]
Taxonomic identifier654901 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]

Protein attributes

Sequence length780 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase large chain family.

Ontologies

Keywords
   Biological processDNA replication
   Developmental stageEarly protein
   LigandATP-binding
Nucleotide-binding
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentribonucleoside-diphosphate reductase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 780780Ribonucleoside-diphosphate reductase large subunit
PRO_0000405696

Regions

Region192 – 1932Substrate binding By similarity
Region393 – 3975Substrate binding By similarity
Region595 – 5995Substrate binding By similarity

Sites

Active site3931Proton acceptor By similarity
Active site3951Cysteine radical intermediate By similarity
Active site3971Proton acceptor By similarity
Binding site1771Substrate By similarity
Binding site2231Substrate; via amide nitrogen By similarity
Site1931Important for hydrogen atom transfer By similarity
Site4091Important for hydrogen atom transfer By similarity
Site7261Important for electron transfer By similarity
Site7271Important for electron transfer By similarity
Site7761Interacts with thioredoxin/glutaredoxin By similarity
Site7791Interacts with thioredoxin/glutaredoxin By similarity

Amino acid modifications

Disulfide bond193 ↔ 409Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
O36411 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 0B4C197AB8D76DDC

FASTA78087,362
        10         20         30         40         50         60 
MASAEATPQQ QIDQLKVNAG WDMKSNIKAG LLHHEEMEKK ATKTVTEYIE KFADVLEENV 

        70         80         90        100        110        120 
LRFLQDNAEM LELCIYMYEQ LPAYKAVKSR GILSAKRFYD TYVLRTADGS CYESVSHCFM 

       130        140        150        160        170        180 
RIAAFCTVQV LTNSALKITI LYLGRDKLFK DLPCSPTMDL FIYFFSPLSH QLVCCATPIM 

       190        200        210        220        230        240 
RSAGLRDANL ASCFLINPDL STEKSTTTAL LQELTMLLSA KSGVGCNVTS FGVDEKCIQS 

       250        260        270        280        290        300 
CVGLINSQVE FFNDQNPRPV SVAAYMEVWH SQIQEFLAVK LPENPSRCAS IYQGLCIPKL 

       310        320        330        340        350        360 
FFEKFIEDPG QNWYLFKPEK SGNLANLYGD EFRSEYERLV GIGCYADAIP IKSLMFLIIN 

       370        380        390        400        410        420 
TIIKTGSPYI IYKEACNEHH WKNMEGCAIA SANLCAEVIQ YPGADVSTCN LANVCLPMCL 

       430        440        450        460        470        480 
VTVSNDSHSP LEKTYCGNVI ESQAVSGVGF SMPILHAAVE VAVFLVNCAI AGGKCVTPGM 

       490        500        510        520        530        540 
ERGQRERSMG IGVHGLADVF AEMGYSYLDE RAARLDVEIF ENMYFRAVKT SNNICRLGGG 

       550        560        570        580        590        600 
RPFEGWGESK LRHGFFHWQG WEDVNLSIPI TEWEKLSRRC ISSGVYNSQF IALMPTVGSS 

       610        620        630        640        650        660 
LLTGFSESYY PYFANISSKV SSKEEVMKPN MTFWNRVSKE DLDTVRFFSG DVALFPEPLK 

       670        680        690        700        710        720 
EKYSLFLSAF DYCAEKQLAR ARLRAPFVDQ SQSHSFHLKE ENVVSARFLK DLILSGYTLG 

       730        740        750        760        770        780 
LKTIMYYCKV KKQSTMSSFQ CLRDQNKSEM TGNDQGVEPE SYIKCTAAGG ETSEACLHCQ 

« Hide

References

[1]"Primary structure of the alcelaphine herpesvirus 1 genome."
Ensser A., Pflanz R., Fleckenstein B.
J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF005370 Genomic DNA. Translation: AAC58108.1.
PIRT03156.
RefSeqNP_065560.1. NC_002531.1.

3D structure databases

ProteinModelPortalO36411.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911785.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

InterProIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSPR01183. RIBORDTASEM1.
SUPFAMSSF48168. SSF48168. 1 hit.
TIGRFAMsTIGR02506. NrdE_NrdA. 1 hit.
PROSITEPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR1_ALHV1
AccessionPrimary (citable) accession number: O36411
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways