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O36411

- RIR1_ALHV1

UniProt

O36411 - RIR1_ALHV1

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Protein
Ribonucleoside-diphosphate reductase large subunit
Gene
61
Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei177 – 1771Substrate By similarity
Sitei193 – 1931Important for hydrogen atom transfer By similarity
Binding sitei223 – 2231Substrate; via amide nitrogen By similarity
Active sitei393 – 3931Proton acceptor By similarity
Active sitei395 – 3951Cysteine radical intermediate By similarity
Active sitei397 – 3971Proton acceptor By similarity
Sitei409 – 4091Important for hydrogen atom transfer By similarity
Sitei726 – 7261Important for electron transfer By similarity
Sitei727 – 7271Important for electron transfer By similarity
Sitei776 – 7761Interacts with thioredoxin/glutaredoxin By similarity
Sitei779 – 7791Interacts with thioredoxin/glutaredoxin By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase large subunit
Gene namesi
Name:61
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
ProteomesiUP000000941: Genome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780Ribonucleoside-diphosphate reductase large subunit
PRO_0000405696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi193 ↔ 409Redox-active By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterodimer of a large and a small chain By similarity.

Structurei

3D structure databases

ProteinModelPortaliO36411.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni192 – 1932Substrate binding By similarity
Regioni393 – 3975Substrate binding By similarity
Regioni595 – 5995Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O36411-1 [UniParc]FASTAAdd to Basket

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MASAEATPQQ QIDQLKVNAG WDMKSNIKAG LLHHEEMEKK ATKTVTEYIE    50
KFADVLEENV LRFLQDNAEM LELCIYMYEQ LPAYKAVKSR GILSAKRFYD 100
TYVLRTADGS CYESVSHCFM RIAAFCTVQV LTNSALKITI LYLGRDKLFK 150
DLPCSPTMDL FIYFFSPLSH QLVCCATPIM RSAGLRDANL ASCFLINPDL 200
STEKSTTTAL LQELTMLLSA KSGVGCNVTS FGVDEKCIQS CVGLINSQVE 250
FFNDQNPRPV SVAAYMEVWH SQIQEFLAVK LPENPSRCAS IYQGLCIPKL 300
FFEKFIEDPG QNWYLFKPEK SGNLANLYGD EFRSEYERLV GIGCYADAIP 350
IKSLMFLIIN TIIKTGSPYI IYKEACNEHH WKNMEGCAIA SANLCAEVIQ 400
YPGADVSTCN LANVCLPMCL VTVSNDSHSP LEKTYCGNVI ESQAVSGVGF 450
SMPILHAAVE VAVFLVNCAI AGGKCVTPGM ERGQRERSMG IGVHGLADVF 500
AEMGYSYLDE RAARLDVEIF ENMYFRAVKT SNNICRLGGG RPFEGWGESK 550
LRHGFFHWQG WEDVNLSIPI TEWEKLSRRC ISSGVYNSQF IALMPTVGSS 600
LLTGFSESYY PYFANISSKV SSKEEVMKPN MTFWNRVSKE DLDTVRFFSG 650
DVALFPEPLK EKYSLFLSAF DYCAEKQLAR ARLRAPFVDQ SQSHSFHLKE 700
ENVVSARFLK DLILSGYTLG LKTIMYYCKV KKQSTMSSFQ CLRDQNKSEM 750
TGNDQGVEPE SYIKCTAAGG ETSEACLHCQ 780
Length:780
Mass (Da):87,362
Last modified:January 1, 1998 - v1
Checksum:i0B4C197AB8D76DDC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58108.1.
PIRiT03156.
RefSeqiNP_065560.1. NC_002531.1.

Genome annotation databases

GeneIDi911785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58108.1 .
PIRi T03156.
RefSeqi NP_065560.1. NC_002531.1.

3D structure databases

ProteinModelPortali O36411.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911785.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

InterProi IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
SUPFAMi SSF48168. SSF48168. 1 hit.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
PROSITEi PS00089. RIBORED_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the alcelaphine herpesvirus 1 genome."
    Ensser A., Pflanz R., Fleckenstein B.
    J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR1_ALHV1
AccessioniPrimary (citable) accession number: O36411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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