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O36410 (RIR2_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:60
OrganismAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]
Taxonomic identifier654901 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Ribonucleoside-diphosphate reductase small chain
PRO_0000405697

Sites

Active site1011 By similarity
Metal binding641Iron 1 By similarity
Metal binding941Iron 1 By similarity
Metal binding941Iron 2 By similarity
Metal binding971Iron 1 By similarity
Metal binding1571Iron 2 By similarity
Metal binding1911Iron 2 By similarity
Metal binding1941Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O36410 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 6431D1DD2F129473

FASTA30535,524
        10         20         30         40         50         60 
MDFIKKYLYV CDHPGFFELT QETFQNRWFP AQINLSVDVK CLSLMSEADV NFYKYLFTFL 

        70         80         90        100        110        120 
GMAETLVNFN IDELLVDFEC HDIKHYYCEQ MAMECVHGKV YFNILNMLFK NNLAATWEFA 

       130        140        150        160        170        180 
EAVLKDEALQ KKLEWLESKI KMAKTKAEKV LIFYLIEGVF FISSFYCIGL LRVKGVMPGV 

       190        200        210        220        230        240 
CMANDYISRD ELLHTRAAAL LYNTMIPKEE RPSSEWVVSL FKEAVEIECA FIEAKTKQVT 

       250        260        270        280        290        300 
FVSMDDIRAF LEATADRLLN SIELPRYYKS DPPQSCPLTY TGCIKNVSFF ERESTEYSSF 


IINDL 

« Hide

References

[1]"Primary structure of the alcelaphine herpesvirus 1 genome."
Ensser A., Pflanz R., Fleckenstein B.
J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF005370 Genomic DNA. Translation: AAC58107.1.
PIRT03155.
RefSeqNP_065559.1. NC_002531.1.

3D structure databases

ProteinModelPortalO36410.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911784.

Phylogenomic databases

ProtClustDBCLSP2509600.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_ALHV1
AccessionPrimary (citable) accession number: O36410
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways