O36410 (RIR2_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonucleoside-diphosphate reductase small chain
EC=1.17.4.1

Alternative name(s):
Ribonucleotide reductase small subunit

Gene names

Name:

60

Organism

Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]

Taxonomic identifier

654901 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Macavirus › Alcelaphine herpesvirus 1

Virus host

Connochaetes taurinus (Brindled gnu) [TaxID: 9927]

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.
Catalytic activity	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Genetic information processing; DNA replication.
Subunit structure	Heterodimer of a large and a small chain By similarity.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Keywords
Biological process	DNA replication
Developmental stage	Early protein
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-UniPathway deoxyribonucleoside diphosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Ribonucleoside-diphosphate reductase small chain		PRO_0000405697
Sites
	Active site	101	1	By similarity
	Metal binding	64	1	Iron 1 By similarity
	Metal binding	94	1	Iron 1 By similarity
	Metal binding	94	1	Iron 2 By similarity
	Metal binding	97	1	Iron 1 By similarity
	Metal binding	157	1	Iron 2 By similarity
	Metal binding	191	1	Iron 2 By similarity
	Metal binding	194	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	O36410 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 6431D1DD2F129473	FASTA	305	35,524
	10 20 30 40 50 60 MDFIKKYLYV CDHPGFFELT QETFQNRWFP AQINLSVDVK CLSLMSEADV NFYKYLFTFL 70 80 90 100 110 120 GMAETLVNFN IDELLVDFEC HDIKHYYCEQ MAMECVHGKV YFNILNMLFK NNLAATWEFA 130 140 150 160 170 180 EAVLKDEALQ KKLEWLESKI KMAKTKAEKV LIFYLIEGVF FISSFYCIGL LRVKGVMPGV 190 200 210 220 230 240 CMANDYISRD ELLHTRAAAL LYNTMIPKEE RPSSEWVVSL FKEAVEIECA FIEAKTKQVT 250 260 270 280 290 300 FVSMDDIRAF LEATADRLLN SIELPRYYKS DPPQSCPLTY TGCIKNVSFF ERESTEYSSF IINDL

References

[1]	"Primary structure of the alcelaphine herpesvirus 1 genome." Ensser A., Pflanz R., Fleckenstein B. J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF005370 Genomic DNA. Translation: AAC58107.1.
PIR	T03155.
RefSeq	NP_065559.1. NC_002531.1.
3D structure databases
ProteinModelPortal	O36410.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911784.
Phylogenomic databases
ProtClustDB	CLSP2509600.
Enzyme and pathway databases
UniPathway	UPA00326.
Family and domain databases
Gene3D	1.10.620.20. 1 hit.
InterPro	IPR009078. Ferritin-like_SF. IPR012348. RNR-rel. IPR000358. RNR_small. [Graphical view]
PANTHER	PTHR23409. PTHR23409. 1 hit.
Pfam	PF00268. Ribonuc_red_sm. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00368. RIBORED_SMALL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RIR2_ALHV1

Accession

Primary (citable) accession number: O36410

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program