Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O36404

- DUT_ALHV1

UniProt

O36404 - DUT_ALHV1

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

54

Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:54
    OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
    Taxonomic identifieri654901 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
    Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
    ProteomesiUP000000941: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000405754Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO36404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 1823Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 3 hits.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 2 hits.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    O36404-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRTLSMRRR QRLEMYYKKV PSVFTVTSNQ EESTLQLVNN KPVVIEPFRS    50
    SVVPLGVYLR CLPGYACMLL ANTYRNVTFH PGLIDPTYMG ELKLICNNRT 100
    DAYVVVPAGR LKVTVLAFTF LSPILTGPSV LSPPQYTDDA GYDLCLDQLV 150
    MVLPLKAFTF QLALTCPIQS KNFTPVVLGR SGLAAKGLSI TPCKWKGDVL 200
    RLSMFNHTSE TIILPEGSRL CQVVFMHNDH LPTIKPRILA AFLFQHRLMD 250
    MPFCQSRVSF IDIQKDPCTS TSTLFQDSTG NSISDATRGS KGLGSSGI 298
    Length:298
    Mass (Da):33,095
    Last modified:January 1, 1998 - v1
    Checksum:i125F96A07A4B18FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005370 Genomic DNA. Translation: AAC58101.1.
    PIRiT03149.
    RefSeqiNP_065553.1. NC_002531.1.

    Genome annotation databases

    GeneIDi911778.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005370 Genomic DNA. Translation: AAC58101.1 .
    PIRi T03149.
    RefSeqi NP_065553.1. NC_002531.1.

    3D structure databases

    ProteinModelPortali O36404.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 911778.

    Family and domain databases

    Gene3Di 2.70.40.10. 3 hits.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the alcelaphine herpesvirus 1 genome."
      Ensser A., Pflanz R., Fleckenstein B.
      J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_ALHV1
    AccessioniPrimary (citable) accession number: O36404
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3