O36404 (DUT_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:

54

Organism

Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]

Taxonomic identifier

654901 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Macavirus › Alcelaphine herpesvirus 1

Virus host

Connochaetes taurinus (Brindled gnu) [TaxID: 9927]

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000405754
Regions
	Region	180 – 182	3	Substrate binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	O36404 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 125F96A07A4B18FA	FASTA	298	33,095
	10 20 30 40 50 60 MSRTLSMRRR QRLEMYYKKV PSVFTVTSNQ EESTLQLVNN KPVVIEPFRS SVVPLGVYLR 70 80 90 100 110 120 CLPGYACMLL ANTYRNVTFH PGLIDPTYMG ELKLICNNRT DAYVVVPAGR LKVTVLAFTF 130 140 150 160 170 180 LSPILTGPSV LSPPQYTDDA GYDLCLDQLV MVLPLKAFTF QLALTCPIQS KNFTPVVLGR 190 200 210 220 230 240 SGLAAKGLSI TPCKWKGDVL RLSMFNHTSE TIILPEGSRL CQVVFMHNDH LPTIKPRILA 250 260 270 280 290 AFLFQHRLMD MPFCQSRVSF IDIQKDPCTS TSTLFQDSTG NSISDATRGS KGLGSSGI

References

[1]	"Primary structure of the alcelaphine herpesvirus 1 genome." Ensser A., Pflanz R., Fleckenstein B. J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF005370 Genomic DNA. Translation: AAC58101.1.
PIR	T03149.
RefSeq	NP_065553.1. NC_002531.1.
3D structure databases
ProteinModelPortal	O36404.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911778.
Phylogenomic databases
ProtClustDB	PHA3131.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_ALHV1

Accession

Primary (citable) accession number: O36404

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program