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O36404 (DUT_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:54
OrganismAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]
Taxonomic identifier654901 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000405754

Regions

Region180 – 1823Substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
O36404 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 125F96A07A4B18FA

FASTA29833,095
        10         20         30         40         50         60 
MSRTLSMRRR QRLEMYYKKV PSVFTVTSNQ EESTLQLVNN KPVVIEPFRS SVVPLGVYLR 

        70         80         90        100        110        120 
CLPGYACMLL ANTYRNVTFH PGLIDPTYMG ELKLICNNRT DAYVVVPAGR LKVTVLAFTF 

       130        140        150        160        170        180 
LSPILTGPSV LSPPQYTDDA GYDLCLDQLV MVLPLKAFTF QLALTCPIQS KNFTPVVLGR 

       190        200        210        220        230        240 
SGLAAKGLSI TPCKWKGDVL RLSMFNHTSE TIILPEGSRL CQVVFMHNDH LPTIKPRILA 

       250        260        270        280        290 
AFLFQHRLMD MPFCQSRVSF IDIQKDPCTS TSTLFQDSTG NSISDATRGS KGLGSSGI 

« Hide

References

[1]"Primary structure of the alcelaphine herpesvirus 1 genome."
Ensser A., Pflanz R., Fleckenstein B.
J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF005370 Genomic DNA. Translation: AAC58101.1.
PIRT03149.
RefSeqNP_065553.1. NC_002531.1.

3D structure databases

ProteinModelPortalO36404.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911778.

Phylogenomic databases

ProtClustDBPHA3131.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_ALHV1
AccessionPrimary (citable) accession number: O36404
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families