Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O36404

- DUT_ALHV1

UniProt

O36404 - DUT_ALHV1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

54

Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:54
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
ProteomesiUP000000941: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000405754Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO36404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1823Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 3 hits.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 2 hits.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.

Sequencei

Sequence statusi: Complete.

O36404-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRTLSMRRR QRLEMYYKKV PSVFTVTSNQ EESTLQLVNN KPVVIEPFRS
60 70 80 90 100
SVVPLGVYLR CLPGYACMLL ANTYRNVTFH PGLIDPTYMG ELKLICNNRT
110 120 130 140 150
DAYVVVPAGR LKVTVLAFTF LSPILTGPSV LSPPQYTDDA GYDLCLDQLV
160 170 180 190 200
MVLPLKAFTF QLALTCPIQS KNFTPVVLGR SGLAAKGLSI TPCKWKGDVL
210 220 230 240 250
RLSMFNHTSE TIILPEGSRL CQVVFMHNDH LPTIKPRILA AFLFQHRLMD
260 270 280 290
MPFCQSRVSF IDIQKDPCTS TSTLFQDSTG NSISDATRGS KGLGSSGI
Length:298
Mass (Da):33,095
Last modified:January 1, 1998 - v1
Checksum:i125F96A07A4B18FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58101.1.
PIRiT03149.
RefSeqiNP_065553.1. NC_002531.1.

Genome annotation databases

GeneIDi911778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58101.1 .
PIRi T03149.
RefSeqi NP_065553.1. NC_002531.1.

3D structure databases

ProteinModelPortali O36404.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911778.

Family and domain databases

Gene3Di 2.70.40.10. 3 hits.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 2 hits.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the alcelaphine herpesvirus 1 genome."
    Ensser A., Pflanz R., Fleckenstein B.
    J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_ALHV1
AccessioniPrimary (citable) accession number: O36404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3