O36386 (AN_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkaline nuclease 37
EC=3.1.-.-

Gene names

Name:

37

Organism

Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]

Taxonomic identifier

654901 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Macavirus › Alcelaphine herpesvirus 1

Virus host

Connochaetes taurinus (Brindled gnu) [TaxID: 9927]

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a role in processing non linear or branched viral DNA intermediates and in capsid egress from the host nucleus By similarity.
Sequence similarities	Belongs to the baculo-herpesviridae alkaline nuclease family.

Ontologies

Keywords
Molecular function	Endonuclease Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW exonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Alkaline nuclease 37		PRO_0000405695

Sequences

	Sequence		Length	Mass (Da)
	O36386 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: C7BD602DD81CD388	FASTA	485	55,605
	10 20 30 40 50 60 MDFLHKATLL EQTLNMEIGE QVKKLATYTF SNFIRCPEVQ QAIASGEIRN DMPHLRFVYI 70 80 90 100 110 120 FYLFKKIQDF IGDTEVFGIY EKVMGVERAN SAKLVDVVQA CTEMRPHIQA QICEHIERLT 130 140 150 160 170 180 RGQGENVLWE VLRDGVISSS KLLKFVKQQT PDSKIFNPIP IQKNHYVASP VAFGVRNETV 190 200 210 220 230 240 VKKLISELVV EEGIGCVTEF GFMLSPNDGI FGVSLDMCTN ASMSDHNTVE FTSTTTIYEI 250 260 270 280 290 300 KCRYKYLFSK CDYDPIYQAY QKLYNSPGRQ ELIDFIQSIQ KPTVEYVSRG RLPTQNDYLL 310 320 330 340 350 360 SFDRSWDFGP PKRKRKLTSG HKITEQCMKY NCYTESKVII LTDPALTSGK IEVKGSFFVD 370 380 390 400 410 420 IYINPRHAYY HQCMLQYKIV TNYVQLTKGD SCKHTHPGVF LVSAFFRKRN SADFPKTYIK 430 440 450 460 470 480 TERSFVDASV EIPVLLIITP VFVPHGPLVD TLEQAIKFWQ VAVKEEFNHW PWAPTSLSAV GDVTP

References

[1]	"Primary structure of the alcelaphine herpesvirus 1 genome." Ensser A., Pflanz R., Fleckenstein B. J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF005370 Genomic DNA. Translation: AAC58083.1.
PIR	T03131.
RefSeq	NP_065535.1. NC_002531.1.
3D structure databases
ProteinModelPortal	O36386.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911801.
Phylogenomic databases
ProtClustDB	CLSP2509676.
Family and domain databases
Gene3D	3.90.320.10. 1 hit.
InterPro	IPR011604. Exonuc_phg/RecB_C. IPR001616. Herpes_alk_exo. IPR011335. Restrct_endonuc-II-like. [Graphical view]
Pfam	PF01771. Herpes_alk_exo. 1 hit. [Graphical view]
PRINTS	PR00924. ALKEXNUCLASE.
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AN_ALHV1

Accession

Primary (citable) accession number: O36386

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program