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Protein

Putative tyrosine kinase 36

Gene

36

Organism
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981ATPBy similarity
Active sitei192 – 1921Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 889ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine kinase 36 (EC:2.7.10.2)
Gene namesi
Name:36
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
ProteomesiUP000000941 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Putative tyrosine kinase 36PRO_0000405713Add
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi339 – 3424Poly-Leu

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O36385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVNRLAYLT AMGSLRPPSP NGDWSKPQDA PHKSVIDMMA SGVSHIKVLK
60 70 80 90 100
VDIDAQHLCV CLPHNMLTCC HPAVDMENLL GSGSFGKVYA SGPGICAKVF
110 120 130 140 150
TSAEAFYHET VMMDLVALAR SYNCDDFKSV CLQFYLSACV TCKTIWYPRF
160 170 180 190 200
SQSLHTFKDF TVDHLHDLDR EFKGLTDAVF FLNQKCGLFH GDICPSNILV
210 220 230 240 250
ETFKGPGSGI KSLILTDLGT AAIHAGNTFK SLSINNPQDD SVIYNAQIYL
260 270 280 290 300
SPFLVCKDYV KPLCVLRRCY LLRHHAQDVD VEEITDTVVG QNMALKIDCS
310 320 330 340 350
TLLQVLLLVL ARVMEQPNSL TYESWLREIE DDSSDAYFLL LLGPKLVLLT
360 370 380 390 400
HLSQLWEINF DVGVNTQGVL SRGQLPHPHT RLLKECCQLF REEFDAVVKE
410 420 430 440 450
EVLIKLGQGV LKNIIFELLQ FDYFEIHGRQ PQHGLFAQSH AARADSEHGN

WRTS
Length:454
Mass (Da):50,929
Last modified:January 1, 1998 - v1
Checksum:i0B652BD91CB45C57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58082.1.
PIRiT03130.
RefSeqiNP_065534.1. NC_002531.1.

Genome annotation databases

GeneIDi911800.
KEGGivg:911800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58082.1.
PIRiT03130.
RefSeqiNP_065534.1. NC_002531.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi911800.
KEGGivg:911800.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure of the alcelaphine herpesvirus 1 genome."
    Ensser A., Pflanz R., Fleckenstein B.
    J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiVG36_ALHV1
AccessioniPrimary (citable) accession number: O36385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.