O36385 (VG36_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine kinase 36
EC=2.7.10.2

Gene names

Name:

36

Organism

Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus) [Reference proteome]

Taxonomic identifier

654901 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Macavirus › Alcelaphine herpesvirus 1

Virus host

Connochaetes taurinus (Brindled gnu) [TaxID: 9927]

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	Putative tyrosine kinase 36		PRO_0000405713
Regions
	Nucleotide binding	80 – 88	9	ATP By similarity
	Compositional bias	339 – 342	4	Poly-Leu
Sites
	Active site	192	1	Proton acceptor By similarity
	Binding site	98	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O36385 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0B652BD91CB45C57	FASTA	454	50,929
	10 20 30 40 50 60 MEVNRLAYLT AMGSLRPPSP NGDWSKPQDA PHKSVIDMMA SGVSHIKVLK VDIDAQHLCV 70 80 90 100 110 120 CLPHNMLTCC HPAVDMENLL GSGSFGKVYA SGPGICAKVF TSAEAFYHET VMMDLVALAR 130 140 150 160 170 180 SYNCDDFKSV CLQFYLSACV TCKTIWYPRF SQSLHTFKDF TVDHLHDLDR EFKGLTDAVF 190 200 210 220 230 240 FLNQKCGLFH GDICPSNILV ETFKGPGSGI KSLILTDLGT AAIHAGNTFK SLSINNPQDD 250 260 270 280 290 300 SVIYNAQIYL SPFLVCKDYV KPLCVLRRCY LLRHHAQDVD VEEITDTVVG QNMALKIDCS 310 320 330 340 350 360 TLLQVLLLVL ARVMEQPNSL TYESWLREIE DDSSDAYFLL LLGPKLVLLT HLSQLWEINF 370 380 390 400 410 420 DVGVNTQGVL SRGQLPHPHT RLLKECCQLF REEFDAVVKE EVLIKLGQGV LKNIIFELLQ 430 440 450 FDYFEIHGRQ PQHGLFAQSH AARADSEHGN WRTS

References

[1]	"Primary structure of the alcelaphine herpesvirus 1 genome." Ensser A., Pflanz R., Fleckenstein B. J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF005370 Genomic DNA. Translation: AAC58082.1.
PIR	T03130.
RefSeq	NP_065534.1. NC_002531.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911800.
Phylogenomic databases
ProtClustDB	CLSP2509675.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR008266. Tyr_kinase_AS. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. False negative. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VG36_ALHV1

Accession

Primary (citable) accession number: O36385

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program