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Protein

Major capsid protein

Gene

MCP

Organism
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
Synonyms:25
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
Proteomesi
  • UP000000941 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13701370Major capsid proteinPRO_0000405715Add
BLAST

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO36375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

O36375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVCRLENRP LPHAAVEANL LRQVKESAAE GLFKSFQLLV GKDVRENSVR
60 70 80 90 100
FEVLLGVYAN VIEFVKFLET GLAASCINTE FRDLKRMVDG KIQFKVSVPT
110 120 130 140 150
IAHSDGRRPN KQRQYIVMKC TSKHHISAEI ELAIADLENM HMEPETDLDM
160 170 180 190 200
LEYIGTVKTV TSALQFGIDA LERGLIDTVL SVKLRHAPPL FILQSLSDPT
210 220 230 240 250
LTERGLKKSI KSDLVSMFKD HLITHSFFIN KAEALATPRQ YILGMLSSII
260 270 280 290 300
NSVSKETVFK GTSTYTTSSG EPVAGVIETT DAILNKLLTL LGEYKTEVVG
310 320 330 340 350
PAAYASYVVR GENLVTAVSY GRAMRSFEQF KNKLVDDPVG QAGSLDKNAD
360 370 380 390 400
SDNEYSSLPQ TTIPVSVVKV GSQPVIVESI QKMYNEAQAP FPLNRRMQYT
410 420 430 440 450
YFFPLGLFIP RPKYTTSTSV KLEDDSCLSS EVWVVNKTNT PLCFNYQNAL
460 470 480 490 500
RTLCHPRVNS PSACLQELQR SNLADNALEA FRDGLRSRPM DNMNLFAHVR
510 520 530 540 550
RFYLKRTEVV LLPIAQKCNL STDDLLHPTN HKLLQLELHP LFDFVVERVA
560 570 580 590 600
AEEAAFRATH RTFSGNIPQP LAPNQFQDSR GKQFEAATSL QHAVDDATLE
610 620 630 640 650
VIRSTAFDPT YPFICYIVEA MIHGQPEKFT MNIPFISLCI NTYWDNSGNL
660 670 680 690 700
AFINSFFMVK NICTHMGGGL INRDAYALYR KILGEVVAIK HAIVRMCGAE
710 720 730 740 750
QLGNNELQGY VNGLLDRQLL PPFAYRDTFA QLDNRGARFV IGAKEHDNSQ
760 770 780 790 800
AFVHALPDFE NANQVAPAMY HTRNTFNWDT FEYITVSNGN NDADAADLEK
810 820 830 840 850
IYYYVMLPVC TNGHMCGMGA DFENIAIVLG YNIPVFDIPQ FNGDDTVLEH
860 870 880 890 900
LENGPLRDIL IASEVNPTAD MLRMMIVSYL NCPQMTQVVR VKTRRDHCQN
910 920 930 940 950
LGPEQGAIIE HTVMVNGFVC FGIPERMKQV AKNMFYPVPF HRFYCDPLVA
960 970 980 990 1000
GSWDNHIQNY VMNNFSQRSL EAFNAPPGIM ADYAEWHKAP MAKYITSCKA
1010 1020 1030 1040 1050
STASLSAFTV MHNKLSPIAF IVQAKHKIHP GFALTVLRTD EVLAENVMFS
1060 1070 1080 1090 1100
ARASTSVFVG RPTVSRREVR ADAVSFEVNH ELATIETGLS YSSVVTPAHV
1110 1120 1130 1140 1150
ASITTDMGIY CQNLFSIFSN EIYDHADVNN YVARKIGVED AVNRHNPRAL
1160 1170 1180 1190 1200
IAGVGQISHP PGLVHGQYAT CEVIPTPVTA DVAYFQKSNS PRGRASCVVS
1210 1220 1230 1240 1250
SDINNQERAE QFLYDHSLPD PAYEYRSTVN PWASQKGSLG DVLYGSRYRQ
1260 1270 1280 1290 1300
VSSPGIYSPS KPFFNKEEML KNNRSFYTLV NEYAQRLAGY AATSCTDLQY
1310 1320 1330 1340 1350
VVINGTDVFL EQPCLFLQEA FPTLSASHRV LLDEYMSFKN THAPVHMGHY
1360 1370
FIEEVAPVKR VFKIGNKVAS
Length:1,370
Mass (Da):153,358
Last modified:January 1, 1998 - v1
Checksum:i7F53E311761A5B9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58072.1.
PIRiT03120.
RefSeqiNP_065524.1. NC_002531.1.

Genome annotation databases

GeneIDi911741.
KEGGivg:911741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58072.1.
PIRiT03120.
RefSeqiNP_065524.1. NC_002531.1.

3D structure databases

ProteinModelPortaliO36375.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi911741.
KEGGivg:911741.

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMCP_ALHV1
AccessioniPrimary (citable) accession number: O36375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.