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O36371

- KITH_ALHV1

UniProt

O36371 - KITH_ALHV1

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Protein

Thymidine kinase

Gene

21

Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721Proton acceptorBy similarity
Binding sitei310 – 3101SubstrateBy similarity
Binding sitei357 – 3571SubstrateBy similarity
Binding sitei400 – 4001ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi245 – 2528ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:21
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
ProteomesiUP000000941: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Thymidine kinasePRO_0000405714Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO36371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O36371-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP
60 70 80 90 100
LPLGRETGRG SRGSTRPKTP RGLVRPRQDA DNPSSDEGFD WEPLESFTSQ
110 120 130 140 150
PGAFSFLEPP RLSSSNTASG LRSSCSDFTI LGSSGENPTS HANLSEEEMY
160 170 180 190 200
EEIPPLASNP SDERHPRQLS GAVAQGAIRK SPRKLKFKPA KFKGLSSSLL
210 220 230 240 250
NPFTASDSGR RARRQTPTCQ PGFTPIFQDL GEPHYVKACT VFFEGCMAAG
260 270 280 290 300
KTTLLNFARQ TLSDDEALTI PEPMRFWTEV YTNVLSQIVK INKECKPGKT
310 320 330 340 350
STTAELVSCQ LKFATPLKTQ SLFLQRSVKK DSEMQPVGPL DKWVIVDRHQ
360 370 380 390 400
LSALVVFPLV LMRRGMLSFS DFFNLLGMFE AHPGEVIALM SVNVEENFTR
410 420 430 440 450
LKKRGRVCER HIDRDYIKEI KGSFNAAYCA WLFLQYFSIQ TTMQICMGLS
460 470 480 490 500
SLDEACATEG VCHTTASRIW NNSMLVTLSD IISQFSNDYT VQNVCYNFFS
510 520 530 540 550
QLSTLKFVVI DLSAFRHDVP GAWGEFYMQV MKNGDIKTRV MDFTAIKALA
560
DTAHNTHASL D
Length:561
Mass (Da):62,796
Last modified:January 1, 1998 - v1
Checksum:i5ED9F2955E4669AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58068.1.
PIRiT03116. A60030.
RefSeqiNP_065520.1. NC_002531.1.

Genome annotation databases

GeneIDi911756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58068.1 .
PIRi T03116. A60030.
RefSeqi NP_065520.1. NC_002531.1.

3D structure databases

ProteinModelPortali O36371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911756.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the alcelaphine herpesvirus 1 genome."
    Ensser A., Pflanz R., Fleckenstein B.
    J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_ALHV1
AccessioniPrimary (citable) accession number: O36371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3