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O36371 (KITH_ALHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Thymidine kinase
PRO_0000405714

Regions

Nucleotide binding245 – 2528ATP By similarity

Sites

Active site2721Proton acceptor By similarity
Binding site3101Substrate By similarity
Binding site3571Substrate By similarity
Binding site4001ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O36371 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5ED9F2955E4669AD

FASTA56162,796
        10         20         30         40         50         60 
MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP LPLGRETGRG 

        70         80         90        100        110        120 
SRGSTRPKTP RGLVRPRQDA DNPSSDEGFD WEPLESFTSQ PGAFSFLEPP RLSSSNTASG 

       130        140        150        160        170        180 
LRSSCSDFTI LGSSGENPTS HANLSEEEMY EEIPPLASNP SDERHPRQLS GAVAQGAIRK 

       190        200        210        220        230        240 
SPRKLKFKPA KFKGLSSSLL NPFTASDSGR RARRQTPTCQ PGFTPIFQDL GEPHYVKACT 

       250        260        270        280        290        300 
VFFEGCMAAG KTTLLNFARQ TLSDDEALTI PEPMRFWTEV YTNVLSQIVK INKECKPGKT 

       310        320        330        340        350        360 
STTAELVSCQ LKFATPLKTQ SLFLQRSVKK DSEMQPVGPL DKWVIVDRHQ LSALVVFPLV 

       370        380        390        400        410        420 
LMRRGMLSFS DFFNLLGMFE AHPGEVIALM SVNVEENFTR LKKRGRVCER HIDRDYIKEI 

       430        440        450        460        470        480 
KGSFNAAYCA WLFLQYFSIQ TTMQICMGLS SLDEACATEG VCHTTASRIW NNSMLVTLSD 

       490        500        510        520        530        540 
IISQFSNDYT VQNVCYNFFS QLSTLKFVVI DLSAFRHDVP GAWGEFYMQV MKNGDIKTRV 

       550        560 
MDFTAIKALA DTAHNTHASL D 

« Hide

References

[1]"Primary structure of the alcelaphine herpesvirus 1 genome."
Ensser A., Pflanz R., Fleckenstein B.
J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF005370 Genomic DNA. Translation: AAC58068.1.
PIRA60030. T03116.
RefSeqNP_065520.1. NC_002531.1.

3D structure databases

ProteinModelPortalO36371.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911756.

Phylogenomic databases

ProtClustDBPHA3132.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_ALHV1
AccessionPrimary (citable) accession number: O36371
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families