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O36371

- KITH_ALHV1

UniProt

O36371 - KITH_ALHV1

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Protein
Thymidine kinase
Gene
21
Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721Proton acceptor By similarity
Binding sitei310 – 3101Substrate By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei400 – 4001ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi245 – 2528ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:21
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
ProteomesiUP000000941: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Thymidine kinase
PRO_0000405714Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliO36371.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O36371-1 [UniParc]FASTAAdd to Basket

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MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP    50
LPLGRETGRG SRGSTRPKTP RGLVRPRQDA DNPSSDEGFD WEPLESFTSQ 100
PGAFSFLEPP RLSSSNTASG LRSSCSDFTI LGSSGENPTS HANLSEEEMY 150
EEIPPLASNP SDERHPRQLS GAVAQGAIRK SPRKLKFKPA KFKGLSSSLL 200
NPFTASDSGR RARRQTPTCQ PGFTPIFQDL GEPHYVKACT VFFEGCMAAG 250
KTTLLNFARQ TLSDDEALTI PEPMRFWTEV YTNVLSQIVK INKECKPGKT 300
STTAELVSCQ LKFATPLKTQ SLFLQRSVKK DSEMQPVGPL DKWVIVDRHQ 350
LSALVVFPLV LMRRGMLSFS DFFNLLGMFE AHPGEVIALM SVNVEENFTR 400
LKKRGRVCER HIDRDYIKEI KGSFNAAYCA WLFLQYFSIQ TTMQICMGLS 450
SLDEACATEG VCHTTASRIW NNSMLVTLSD IISQFSNDYT VQNVCYNFFS 500
QLSTLKFVVI DLSAFRHDVP GAWGEFYMQV MKNGDIKTRV MDFTAIKALA 550
DTAHNTHASL D 561
Length:561
Mass (Da):62,796
Last modified:January 1, 1998 - v1
Checksum:i5ED9F2955E4669AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58068.1.
PIRiT03116. A60030.
RefSeqiNP_065520.1. NC_002531.1.

Genome annotation databases

GeneIDi911756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005370 Genomic DNA. Translation: AAC58068.1 .
PIRi T03116. A60030.
RefSeqi NP_065520.1. NC_002531.1.

3D structure databases

ProteinModelPortali O36371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 911756.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the alcelaphine herpesvirus 1 genome."
    Ensser A., Pflanz R., Fleckenstein B.
    J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_ALHV1
AccessioniPrimary (citable) accession number: O36371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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