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O36371

- KITH_ALHV1

UniProt

O36371 - KITH_ALHV1

Protein

Thymidine kinase

Gene

21

Organism
Alcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei272 – 2721Proton acceptorBy similarity
    Binding sitei310 – 3101SubstrateBy similarity
    Binding sitei357 – 3571SubstrateBy similarity
    Binding sitei400 – 4001ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi245 – 2528ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:21
    OrganismiAlcelaphine herpesvirus 1 (strain C500) (AIHV-1) (Malignant catarrhal fever virus)
    Taxonomic identifieri654901 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
    Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
    ProteomesiUP000000941: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Thymidine kinasePRO_0000405714Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO36371.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O36371-1 [UniParc]FASTAAdd to Basket

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    MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP    50
    LPLGRETGRG SRGSTRPKTP RGLVRPRQDA DNPSSDEGFD WEPLESFTSQ 100
    PGAFSFLEPP RLSSSNTASG LRSSCSDFTI LGSSGENPTS HANLSEEEMY 150
    EEIPPLASNP SDERHPRQLS GAVAQGAIRK SPRKLKFKPA KFKGLSSSLL 200
    NPFTASDSGR RARRQTPTCQ PGFTPIFQDL GEPHYVKACT VFFEGCMAAG 250
    KTTLLNFARQ TLSDDEALTI PEPMRFWTEV YTNVLSQIVK INKECKPGKT 300
    STTAELVSCQ LKFATPLKTQ SLFLQRSVKK DSEMQPVGPL DKWVIVDRHQ 350
    LSALVVFPLV LMRRGMLSFS DFFNLLGMFE AHPGEVIALM SVNVEENFTR 400
    LKKRGRVCER HIDRDYIKEI KGSFNAAYCA WLFLQYFSIQ TTMQICMGLS 450
    SLDEACATEG VCHTTASRIW NNSMLVTLSD IISQFSNDYT VQNVCYNFFS 500
    QLSTLKFVVI DLSAFRHDVP GAWGEFYMQV MKNGDIKTRV MDFTAIKALA 550
    DTAHNTHASL D 561
    Length:561
    Mass (Da):62,796
    Last modified:January 1, 1998 - v1
    Checksum:i5ED9F2955E4669AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005370 Genomic DNA. Translation: AAC58068.1.
    PIRiT03116. A60030.
    RefSeqiNP_065520.1. NC_002531.1.

    Genome annotation databases

    GeneIDi911756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF005370 Genomic DNA. Translation: AAC58068.1 .
    PIRi T03116. A60030.
    RefSeqi NP_065520.1. NC_002531.1.

    3D structure databases

    ProteinModelPortali O36371.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 911756.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the alcelaphine herpesvirus 1 genome."
      Ensser A., Pflanz R., Fleckenstein B.
      J. Virol. 71:6517-6525(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_ALHV1
    AccessioniPrimary (citable) accession number: O36371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3