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Protein

DNA polymerase catalytic subunit

Gene

9

Organism
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Replicates viral genomic DNA.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase catalytic subunit (EC:2.7.7.7)
Gene namesi
Name:9
OrganismiAlcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri654901 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes taurinus (Blue wildebeest) [TaxID: 9927]
Proteomesi
  • UP000000941 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10261026DNA polymerase catalytic subunitPRO_0000405694Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO36363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili664 – 69532Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 74Poly-Phe

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

KOiK18964.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O36363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCFFFFSLQ PCLFKLPLPL PLKKNTAMLS FWNPYLRGFK APTPATKSKP
60 70 80 90 100
KASTIYHRLI PKCFKKDERE NGGIFAIETA IPPTAFYLDS ELLVLPENKS
110 120 130 140 150
SLWANETLGN CHSIQELMFH VYDIVEVVYA ADRCDSIPPH LQADIVPSGI
160 170 180 190 200
VLKLYGRTET NQSVCVNVFG QKVYFYVYND SYSNLQRDVQ HILQETGHRS
210 220 230 240 250
TGLHLCSTQK KFLSGYSTSS HEVYQITLGS SSAMRSLASG LEQIGYRVFE
260 270 280 290 300
ANVDASTRFI VDNKFSTFGW YTCTSPLARP RVHQDAHTHL EYDCSVGDIQ
310 320 330 340 350
YHAERLDWPQ YNILSFDIEC LGESGFPSAD KDEDMIIQIS CVIWTVGGDK
360 370 380 390 400
KQECILLSVG TCDLIENVKV YEFPSEMDLL YGFFTLLRDY GIEMITGYNI
410 420 430 440 450
CNFDFPYILN RAQNVYNIKP EDFSKTKTNS LFYVYTPQEG NFMRSHSKVK
460 470 480 490 500
MSGVVVIDMY QVCRDKLNLS NYKLNTVAKE CLGEKKNDVS YKDIPILFKG
510 520 530 540 550
SSKDRAKLGM YCVQDAVLVI DLLKHFMTHI EITEIAKIAN IPTRRVLSDG
560 570 580 590 600
QQIRVFTCLL AAAQERDYIL PMPVTGSQEG YQGATVINPI SGFYNTPVLV
610 620 630 640 650
VDFASLYPSI IQAHNLCYST LIKQQDLPKF TNLTANDYET FMISGGPVHF
660 670 680 690 700
VKKHKTESLL ASLLKTWLAK RKSIKKELEQ CQDAKMKTIL DKQQLAIKVT
710 720 730 740 750
CNSVYGFTGV ASGMLPCLMI AETVTLQGRT MLEKTKQFVE NVTVEYLQKI
760 770 780 790 800
CNFEVQCLPQ HPNPKFRVVY GDTDSLFIKC EGFAMDTVIK FGDALASHTS
810 820 830 840 850
SVLFASPIKL ESEKVFKCLM LLTKKRYVGI LSNNKILMKG VDLVRKTACV
860 870 880 890 900
YVQEVTRAVL ELLLRDEEVK VAAQTLSYSP VANCFKTEPL LGFLKIIDIL
910 920 930 940 950
NQSYSDLKSN KVPVANLTYS TELSKPFTEY KTTNLPHLAV YKKLAMRNEE
960 970 980 990 1000
LPQIHDRISY VFVKSNGHLV SDMAEDPTYA EQNKIPIASD WYFDKIIHGV
1010 1020
ANILQCVFNN NTSATVEVLY NFVRNP
Length:1,026
Mass (Da):116,255
Last modified:January 1, 1998 - v1
Checksum:iC6211A5B65A9CEDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58060.1.
PIRiT03108.
RefSeqiNP_065512.1. NC_002531.1.

Genome annotation databases

GeneIDi911748.
KEGGivg:911748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005370 Genomic DNA. Translation: AAC58060.1.
PIRiT03108.
RefSeqiNP_065512.1. NC_002531.1.

3D structure databases

ProteinModelPortaliO36363.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi911748.
KEGGivg:911748.

Phylogenomic databases

KOiK18964.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPOL_ALHV1
AccessioniPrimary (citable) accession number: O36363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.