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Protein

Glutaredoxin-1

Gene

grx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase. Thioltransferase catalyzes cellular thiol-disulfide transhydrogenation reactions. It transfers reducing equivalents to cytosolic protein and nonprotein disulfides (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Gene namesi
Name:grx1
ORF Names:SPAC4F10.20
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.20.
PomBaseiSPAC4F10.20. grx1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Glutaredoxin-1PRO_0000141610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 28Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO36032.

Interactioni

Protein-protein interaction databases

BioGridi279973. 2 interactions.
MINTiMINT-4673029.

Structurei

3D structure databases

ProteinModelPortaliO36032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 10197GlutaredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000095204.
InParanoidiO36032.
KOiK03676.
OMAiMANIQAY.
OrthoDBiEOG092C3ZJC.
PhylomeDBiO36032.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O36032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVESFVDS AVADNDVVVF AKSYCPYCHA TEKVIADKKI KAQVYQIDLM
60 70 80 90 100
NNGDEIQSYL LKKTGQRTVP NIFIHQKHVG GNSDFQALFK KGELDSLFNT

A
Length:101
Mass (Da):11,261
Last modified:January 1, 1998 - v1
Checksum:i30557E19BF33E9BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521N → D in AAF19628 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015167 mRNA. Translation: BAA28750.1.
AF121275 mRNA. Translation: AAD25391.1.
AF192764 Genomic DNA. Translation: AAF19628.1.
CU329670 Genomic DNA. Translation: CAB11722.1.
PIRiT38824.
RefSeqiNP_594763.1. NM_001020190.2.

Genome annotation databases

EnsemblFungiiSPAC4F10.20.1; SPAC4F10.20.1:pep; SPAC4F10.20.
GeneIDi2543556.
KEGGispo:SPAC4F10.20.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015167 mRNA. Translation: BAA28750.1.
AF121275 mRNA. Translation: AAD25391.1.
AF192764 Genomic DNA. Translation: AAF19628.1.
CU329670 Genomic DNA. Translation: CAB11722.1.
PIRiT38824.
RefSeqiNP_594763.1. NM_001020190.2.

3D structure databases

ProteinModelPortaliO36032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279973. 2 interactions.
MINTiMINT-4673029.

Proteomic databases

MaxQBiO36032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4F10.20.1; SPAC4F10.20.1:pep; SPAC4F10.20.
GeneIDi2543556.
KEGGispo:SPAC4F10.20.

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.20.
PomBaseiSPAC4F10.20. grx1.

Phylogenomic databases

HOGENOMiHOG000095204.
InParanoidiO36032.
KOiK03676.
OMAiMANIQAY.
OrthoDBiEOG092C3ZJC.
PhylomeDBiO36032.

Miscellaneous databases

PROiO36032.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLRX1_SCHPO
AccessioniPrimary (citable) accession number: O36032
Secondary accession number(s): Q9US58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.