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O36032 (GLRX1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaredoxin-1
Gene names
Name:grx1
ORF Names:SPAC4F10.20
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase. Thioltransferase catalyzes cellular thiol-disulfide transhydrogenation reactions. It transfers reducing equivalents to cytosolic protein and nonprotein disulfides By similarity.

Sequence similarities

Belongs to the glutaredoxin family.

Contains 1 glutaredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 101101Glutaredoxin-1
PRO_0000141610

Regions

Domain5 – 10197Glutaredoxin

Amino acid modifications

Disulfide bond25 ↔ 28Redox-active By similarity

Experimental info

Sequence conflict521N → D in AAF19628. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O36032 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 30557E19BF33E9BB

FASTA10111,261
        10         20         30         40         50         60 
MSSVESFVDS AVADNDVVVF AKSYCPYCHA TEKVIADKKI KAQVYQIDLM NNGDEIQSYL 

        70         80         90        100 
LKKTGQRTVP NIFIHQKHVG GNSDFQALFK KGELDSLFNT A

« Hide

References

« Hide 'large scale' references
[1]"S.pombe glutaredoxin."
Kawamukai M.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of cDNA encoding thioltransferase (glutaredoxin) from Schizosaccharomyces pombe."
Kim H.-G., Cho Y.-W., Park E.-H., Lim C.-J.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Isolation and expression of the genomic DNA encoding thioltransferase (Glutaredoxin) from Schizosaccharomyces pombe."
Cho Y.-W., Kim H.-G., Lim C.-J.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB015167 mRNA. Translation: BAA28750.1.
AF121275 mRNA. Translation: AAD25391.1.
AF192764 Genomic DNA. Translation: AAF19628.1.
CU329670 Genomic DNA. Translation: CAB11722.1.
PIRT38824.
RefSeqNP_594763.1. NM_001020190.1.

3D structure databases

ProteinModelPortalO36032.
ModBaseSearch...

Protein-protein interaction databases

STRINGO36032.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC4F10.20.1; SPAC4F10.20.1:pep; SPAC4F10.20.
GeneID2543556.
GenomeReviewsGene locus grx1 in contig CU329670_GR.
KEGGspo:SPAC4F10.20.
NMPDRfig|4896.1.peg.4733.

Organism-specific databases

GeneDB_SpombeSPAC4F10.20.

Phylogenomic databases

eggNOGfuNOG12136.
GeneTreeEFGT00050000002871.
HOGENOMHBG728471.
OMAQYELLEF.
OrthoDBEOG4V1B9J.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-002839-MONOMER.

Gene expression databases

ArrayExpressO36032.

Family and domain databases

InterProIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK03676.
PfamPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSPR00160. GLUTAREDOXIN.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMsTIGR02180. GRX_euk. 1 hit.
PROSITEPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLRX1_SCHPO
AccessionPrimary (citable) accession number: O36032
Secondary accession number(s): Q9US58
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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