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Protein

Putative phospholipid-transporting ATPase C4F10.16c

Gene

SPAC4F10.16c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.By similarity

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei600 – 60014-aspartylphosphate intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phospholipid-transporting ATPase C4F10.16c (EC:3.6.3.1)
Gene namesi
ORF Names:SPAC4F10.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.16c.
PomBaseiSPAC4F10.16c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 154154CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17218HelicalSequence analysisAdd
BLAST
Topological domaini173 – 1775LumenalSequence analysis
Transmembranei178 – 19720HelicalSequence analysisAdd
BLAST
Topological domaini198 – 482285CytoplasmicSequence analysisAdd
BLAST
Transmembranei483 – 50321HelicalSequence analysisAdd
BLAST
Topological domaini504 – 53128LumenalSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Topological domaini553 – 1091539CytoplasmicSequence analysisAdd
BLAST
Transmembranei1092 – 111221HelicalSequence analysisAdd
BLAST
Topological domaini1113 – 112412LumenalSequence analysisAdd
BLAST
Transmembranei1125 – 114521HelicalSequence analysisAdd
BLAST
Topological domaini1146 – 117429CytoplasmicSequence analysisAdd
BLAST
Transmembranei1175 – 119723HelicalSequence analysisAdd
BLAST
Topological domaini1198 – 121215LumenalSequence analysisAdd
BLAST
Transmembranei1213 – 123321HelicalSequence analysisAdd
BLAST
Topological domaini1234 – 12407CytoplasmicSequence analysis
Transmembranei1241 – 126121HelicalSequence analysisAdd
BLAST
Topological domaini1262 – 127615LumenalSequence analysisAdd
BLAST
Transmembranei1277 – 129721HelicalSequence analysisAdd
BLAST
Topological domaini1298 – 136770CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13671367Putative phospholipid-transporting ATPase C4F10.16cPRO_0000343137Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi279941. 8 interactions.
MINTiMINT-4672996.

Structurei

3D structure databases

ProteinModelPortaliO36028.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202528.
InParanoidiO36028.
KOiK01530.
OMAiANSAIHE.
OrthoDBiEOG7FR7QR.
PhylomeDBiO36028.

Family and domain databases

Gene3Di2.70.150.10. 3 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
IPR026871. PLip_transp_ATPase.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PTHR24092:SF87. PTHR24092:SF87. 2 hits.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O36028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLINFDAI SSLKSSLHGL SICAFNHLHH VPQHNGSLAH EGPTNQTDYS
60 70 80 90 100
SRHHESQFSQ EAHAEQRSRD DEEANSFEGS CNNSDQSWTS RVTSKKNEAG
110 120 130 140 150
TESGDASVRR IYVTSIPEEH RHLPSQWFPS NKIRTTKYTP VSFIPKNLWN
160 170 180 190 200
QFKNIANAFF LFVTLLQCIP LFCPEHLGLS FIPLSVILLT TAIKDGIEDY
210 220 230 240 250
RRCVLDKKFN NTLTWKLVGF NNANALGEHI GLWRKLKKFI SHTVADMSYC
260 270 280 290 300
LKNSGISSGL ATLTVDNISH RHSLESDSAF TLSSVSQDSL EIHEIGNSGP
310 320 330 340 350
SNSFSVIQEQ STGSSNAKFE RVCRKSLLVG DIVKVLADEA IPADLLILST
360 370 380 390 400
ENSNGVCYVE TKNLDGETNL KDKYALCSTK CCKSEYRCSA ASFWVECEQP
410 420 430 440 450
HADLYSLNGV VKAPGAVQSP SESTNGRKIH EEPFSISNVL LCGCTLRNSK
460 470 480 490 500
WVIGLVLYTG SETRIQKNRG LTPSKRSRIT RDLNWTIILN FLLLFAMCLF
510 520 530 540 550
SGVLRSIYSA QNNSARVFEL SKNSNTAPAH GIISIFTSLI LFQNLVPISL
560 570 580 590 600
YITMDIVRSI QSYFIFSDRE MYDEKLDCPC SPKSWNISDD LGQIEYIFSD
610 620 630 640 650
KTGTLTQNIM SFKKCSINGI RYGKSHNEDT CIKKRRNLNY NENLSCKVDL
660 670 680 690 700
DKKKMLETLS LSDSPNPESI TFISSKFVDH LQSNENYIQT EACFEFFKAL
710 720 730 740 750
ALCHSVVTDV QDETLIYNAQ SPDEEALVKV ARDFGFTLLN TKNRRYTIRI
760 770 780 790 800
RGENKNFRVL DIIPFTSTRK RMSVIIRDED GIIHLICKGA DTVIFPRLSS
810 820 830 840 850
GQNNIIEKTK KHLASFSSEG FRTLCIARRT IDKQDYLEWK VNFNEANSAI
860 870 880 890 900
HERNEKVSKV SEMIEQELEL LGGTAIEDKL QENVPETIAL LAIAGIKLWV
910 920 930 940 950
LTGDKVETAI NIGYSCNLLD PNMTIFRIDA NSFGALEEVE AFIRNTLCFN
960 970 980 990 1000
FGYMGTDEEF RFLLKDHSPP SPKHAIVIDG DALNFVLSEQ VSFLFLMLCK
1010 1020 1030 1040 1050
QCKTVLCCRV SPSQKAAVVA LVKKSLNVVT LAIGDGANDV SMIQEADVGV
1060 1070 1080 1090 1100
GIKGVEGQAA SMSADYAIGQ FSFLGRLLLV HGRWDYKRMS QMISFFFYKN
1110 1120 1130 1140 1150
VIWTFILFWY QFYNEFDGNY IFDYTYVMLF NLLFTSLPVI IAGCFDQDVD
1160 1170 1180 1190 1200
ASVSMKNPSL YQRGILGLEW NGKRFWSYML DGIYQSLVCF GVALFVFKFG
1210 1220 1230 1240 1250
DFVSWTGRNI ECIEDIGLFI SSPTIFVINI FILMNQERLN LISLITWMFS
1260 1270 1280 1290 1300
IGVFWIWTFI YSEVGPSYAF HKSASRTCQT FGFWCVTVLT IALCLLPRFS
1310 1320 1330 1340 1350
YICLQKLFYP RDIDLLRRRL CAKSDDETSS SSSFATDIEM CEQCNDPLSS
1360
KKNSGIVTSV SFDDSNK
Length:1,367
Mass (Da):154,282
Last modified:January 1, 1998 - v1
Checksum:i4DCFD8A7479465EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11719.1.
PIRiT38820.
RefSeqiNP_594759.1. NM_001020186.2.

Genome annotation databases

EnsemblFungiiSPAC4F10.16c.1; SPAC4F10.16c.1:pep; SPAC4F10.16c.
GeneIDi2543523.
KEGGispo:SPAC4F10.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11719.1.
PIRiT38820.
RefSeqiNP_594759.1. NM_001020186.2.

3D structure databases

ProteinModelPortaliO36028.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279941. 8 interactions.
MINTiMINT-4672996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4F10.16c.1; SPAC4F10.16c.1:pep; SPAC4F10.16c.
GeneIDi2543523.
KEGGispo:SPAC4F10.16c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.16c.
PomBaseiSPAC4F10.16c.

Phylogenomic databases

HOGENOMiHOG000202528.
InParanoidiO36028.
KOiK01530.
OMAiANSAIHE.
OrthoDBiEOG7FR7QR.
PhylomeDBiO36028.

Enzyme and pathway databases

ReactomeiR-SPO-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiO36028.

Family and domain databases

Gene3Di2.70.150.10. 3 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
IPR026871. PLip_transp_ATPase.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PTHR24092:SF87. PTHR24092:SF87. 2 hits.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATCZ_SCHPO
AccessioniPrimary (citable) accession number: O36028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.