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O35988

- SDC4_MOUSE

UniProt

O35988 - SDC4_MOUSE

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Protein

Syndecan-4

Gene

Sdc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate.

GO - Molecular functioni

  1. thrombospondin receptor activity Source: Ensembl

GO - Biological processi

  1. positive regulation of focal adhesion assembly Source: Ensembl
  2. positive regulation of protein kinase activity Source: Ensembl
  3. positive regulation of stress fiber assembly Source: Ensembl
  4. ureteric bud development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196644. Syndecan interactions.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_270174. Defective EXT2 causes exostoses 2.
REACT_271374. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-4
Short name:
SYND4
Alternative name(s):
Ryudocan core protein
Gene namesi
Name:Sdc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1349164. Sdc4.

Subcellular locationi

Membrane; Single-pass type I membrane protein. Secreted
Note: Shedding of the ectodomain produces a soluble form.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 145122ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 17025HelicalSequence AnalysisAdd
BLAST
Topological domaini171 – 19828CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. costamere Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. focal adhesion Source: Ensembl
  5. Golgi lumen Source: Reactome
  6. integral component of membrane Source: UniProtKB-KW
  7. membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 198175Syndecan-4PRO_0000033512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441O-linked (Xyl...) (heparan sulfate)By similarity
Glycosylationi62 – 621O-linked (Xyl...) (heparan sulfate)Sequence Analysis
Glycosylationi64 – 641O-linked (Xyl...) (heparan sulfate)Sequence Analysis

Post-translational modificationi

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

MaxQBiO35988.
PaxDbiO35988.
PRIDEiO35988.

PTM databases

PhosphoSiteiO35988.

Miscellaneous databases

PMAP-CutDBO35988.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in liver, kidney and lung.

Gene expression databases

BgeeiO35988.
CleanExiMM_SDC4.
ExpressionAtlasiO35988. baseline and differential.
GenevestigatoriO35988.

Interactioni

Subunit structurei

Homodimer. Interacts with CDCP1 and SDCBP (By similarity). Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1.By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017153.

Structurei

3D structure databases

ProteinModelPortaliO35988.
SMRiO35988. Positions 171-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG83582.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiO35988.
KOiK16338.
OMAiIPKRISP.
OrthoDBiEOG7RV9HS.
PhylomeDBiO35988.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35988-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPACLLAPL LLLLLGGFPL VPGESIRETE VIDPQDLLEG RYFSGALPDD
60 70 80 90 100
EDAGGSDDFE LSGSGDLDDT EEPRPFPEVI EPLVPLDNHI PENAQPGIRV
110 120 130 140 150
PSEPKELEEN EVIPKRAPSD VGDDMSNKVS MSSTAQGSNI FERTEVLAAL
160 170 180 190
IVGGVVGILF AVFLILLLVY RMKKKDEGSY DLGKKPIYKK APTNEFYA
Length:198
Mass (Da):21,482
Last modified:January 1, 1998 - v1
Checksum:i4246963EC6A25915
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89571 mRNA. Translation: BAA22135.1.
D89572 Genomic DNA. Translation: BAA22136.1.
BC005679 mRNA. Translation: AAH05679.1.
CCDSiCCDS17036.1.
PIRiJC5613.
RefSeqiNP_035651.1. NM_011521.2.
UniGeneiMm.3815.

Genome annotation databases

EnsembliENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009.
GeneIDi20971.
KEGGimmu:20971.
UCSCiuc008nuq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89571 mRNA. Translation: BAA22135.1 .
D89572 Genomic DNA. Translation: BAA22136.1 .
BC005679 mRNA. Translation: AAH05679.1 .
CCDSi CCDS17036.1.
PIRi JC5613.
RefSeqi NP_035651.1. NM_011521.2.
UniGenei Mm.3815.

3D structure databases

ProteinModelPortali O35988.
SMRi O35988. Positions 171-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000017153.

Chemistry

ChEMBLi CHEMBL2062355.

PTM databases

PhosphoSitei O35988.

Proteomic databases

MaxQBi O35988.
PaxDbi O35988.
PRIDEi O35988.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017153 ; ENSMUSP00000017153 ; ENSMUSG00000017009 .
GeneIDi 20971.
KEGGi mmu:20971.
UCSCi uc008nuq.1. mouse.

Organism-specific databases

CTDi 6385.
MGIi MGI:1349164. Sdc4.

Phylogenomic databases

eggNOGi NOG83582.
HOGENOMi HOG000263414.
HOVERGENi HBG004501.
InParanoidi O35988.
KOi K16338.
OMAi IPKRISP.
OrthoDBi EOG7RV9HS.
PhylomeDBi O35988.
TreeFami TF320463.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196644. Syndecan interactions.
REACT_198569. Retinoid metabolism and transport.
REACT_198654. HS-GAG biosynthesis.
REACT_198967. HS-GAG degradation.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_270174. Defective EXT2 causes exostoses 2.
REACT_271374. Defective EXT1 causes exostoses 1, TRPS2 and CHDS.

Miscellaneous databases

ChiTaRSi Sdc4. mouse.
NextBioi 299938.
PMAP-CutDB O35988.
PROi O35988.
SOURCEi Search...

Gene expression databases

Bgeei O35988.
CleanExi MM_SDC4.
ExpressionAtlasi O35988. baseline and differential.
Genevestigatori O35988.

Family and domain databases

InterProi IPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
PANTHERi PTHR10915. PTHR10915. 1 hit.
Pfami PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
[Graphical view ]
PROSITEi PS00964. SYNDECAN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, genomic organization, promoter activity, and tissue-specific expression of the mouse ryudocan gene."
    Tsuzuki S., Kojima T., Katsumi A., Yamazaki T., Sugiura I., Saito H.
    J. Biochem. 122:17-24(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ and C3H/An.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase."
    Fitzgerald M.L., Wang Z., Park P.W., Murphy G., Bernfield M.
    J. Cell Biol. 148:811-824(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SHEDDING.
  4. "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration."
    Gao Y., Li M., Chen W., Simons M.
    J. Cell. Physiol. 184:373-379(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GIPC.
  5. "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5."
    Denhez F., Wilcox-Adelman S.A., Baciu P.C., Saoncella S., Lee S., French B., Neveu W., Goetinck P.F.
    J. Biol. Chem. 277:12270-12274(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NUDT16L1.

Entry informationi

Entry nameiSDC4_MOUSE
AccessioniPrimary (citable) accession number: O35988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3