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O35988

- SDC4_MOUSE

UniProt

O35988 - SDC4_MOUSE

Protein

Syndecan-4

Gene

Sdc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cell surface proteoglycan that bears heparan sulfate.

    GO - Molecular functioni

    1. thrombospondin receptor activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of focal adhesion assembly Source: Ensembl
    2. positive regulation of protein kinase activity Source: Ensembl
    3. positive regulation of stress fiber assembly Source: Ensembl
    4. ureteric bud development Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196644. Syndecan interactions.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syndecan-4
    Short name:
    SYND4
    Alternative name(s):
    Ryudocan core protein
    Gene namesi
    Name:Sdc4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1349164. Sdc4.

    Subcellular locationi

    Membrane; Single-pass type I membrane protein. Secreted
    Note: Shedding of the ectodomain produces a soluble form.

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. costamere Source: Ensembl
    3. extracellular region Source: UniProtKB-SubCell
    4. focal adhesion Source: Ensembl
    5. Golgi lumen Source: Reactome
    6. integral component of membrane Source: UniProtKB-KW
    7. membrane raft Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 198175Syndecan-4PRO_0000033512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441O-linked (Xyl...) (heparan sulfate)By similarity
    Glycosylationi62 – 621O-linked (Xyl...) (heparan sulfate)Sequence Analysis
    Glycosylationi64 – 641O-linked (Xyl...) (heparan sulfate)Sequence Analysis

    Post-translational modificationi

    Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

    Keywords - PTMi

    Glycoprotein, Heparan sulfate, Proteoglycan

    Proteomic databases

    MaxQBiO35988.
    PaxDbiO35988.
    PRIDEiO35988.

    PTM databases

    PhosphoSiteiO35988.

    Miscellaneous databases

    PMAP-CutDBO35988.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest levels in liver, kidney and lung.

    Gene expression databases

    ArrayExpressiO35988.
    BgeeiO35988.
    CleanExiMM_SDC4.
    GenevestigatoriO35988.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CDCP1 and SDCBP By similarity. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1.By similarity2 Publications

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000017153.

    Structurei

    3D structure databases

    ProteinModelPortaliO35988.
    SMRiO35988. Positions 171-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 145122ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19828CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei146 – 17025HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the syndecan proteoglycan family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG83582.
    HOGENOMiHOG000263414.
    HOVERGENiHBG004501.
    InParanoidiO35988.
    KOiK16338.
    OMAiIPKRISP.
    OrthoDBiEOG7RV9HS.
    PhylomeDBiO35988.
    TreeFamiTF320463.

    Family and domain databases

    InterProiIPR003585. Neurexin-like.
    IPR001050. Syndecan.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view]
    PANTHERiPTHR10915. PTHR10915. 1 hit.
    PfamiPF01034. Syndecan. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    [Graphical view]
    PROSITEiPS00964. SYNDECAN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35988-1 [UniParc]FASTAAdd to Basket

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    MAPACLLAPL LLLLLGGFPL VPGESIRETE VIDPQDLLEG RYFSGALPDD    50
    EDAGGSDDFE LSGSGDLDDT EEPRPFPEVI EPLVPLDNHI PENAQPGIRV 100
    PSEPKELEEN EVIPKRAPSD VGDDMSNKVS MSSTAQGSNI FERTEVLAAL 150
    IVGGVVGILF AVFLILLLVY RMKKKDEGSY DLGKKPIYKK APTNEFYA 198
    Length:198
    Mass (Da):21,482
    Last modified:January 1, 1998 - v1
    Checksum:i4246963EC6A25915
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89571 mRNA. Translation: BAA22135.1.
    D89572 Genomic DNA. Translation: BAA22136.1.
    BC005679 mRNA. Translation: AAH05679.1.
    CCDSiCCDS17036.1.
    PIRiJC5613.
    RefSeqiNP_035651.1. NM_011521.2.
    UniGeneiMm.3815.

    Genome annotation databases

    EnsembliENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009.
    GeneIDi20971.
    KEGGimmu:20971.
    UCSCiuc008nuq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89571 mRNA. Translation: BAA22135.1 .
    D89572 Genomic DNA. Translation: BAA22136.1 .
    BC005679 mRNA. Translation: AAH05679.1 .
    CCDSi CCDS17036.1.
    PIRi JC5613.
    RefSeqi NP_035651.1. NM_011521.2.
    UniGenei Mm.3815.

    3D structure databases

    ProteinModelPortali O35988.
    SMRi O35988. Positions 171-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000017153.

    Chemistry

    ChEMBLi CHEMBL2062355.

    PTM databases

    PhosphoSitei O35988.

    Proteomic databases

    MaxQBi O35988.
    PaxDbi O35988.
    PRIDEi O35988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017153 ; ENSMUSP00000017153 ; ENSMUSG00000017009 .
    GeneIDi 20971.
    KEGGi mmu:20971.
    UCSCi uc008nuq.1. mouse.

    Organism-specific databases

    CTDi 6385.
    MGIi MGI:1349164. Sdc4.

    Phylogenomic databases

    eggNOGi NOG83582.
    HOGENOMi HOG000263414.
    HOVERGENi HBG004501.
    InParanoidi O35988.
    KOi K16338.
    OMAi IPKRISP.
    OrthoDBi EOG7RV9HS.
    PhylomeDBi O35988.
    TreeFami TF320463.

    Enzyme and pathway databases

    Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196644. Syndecan interactions.
    REACT_198569. Retinoid metabolism and transport.
    REACT_198654. HS-GAG biosynthesis.
    REACT_198967. HS-GAG degradation.

    Miscellaneous databases

    ChiTaRSi SDC4. mouse.
    NextBioi 299938.
    PMAP-CutDB O35988.
    PROi O35988.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35988.
    Bgeei O35988.
    CleanExi MM_SDC4.
    Genevestigatori O35988.

    Family and domain databases

    InterProi IPR003585. Neurexin-like.
    IPR001050. Syndecan.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view ]
    PANTHERi PTHR10915. PTHR10915. 1 hit.
    Pfami PF01034. Syndecan. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    [Graphical view ]
    PROSITEi PS00964. SYNDECAN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, genomic organization, promoter activity, and tissue-specific expression of the mouse ryudocan gene."
      Tsuzuki S., Kojima T., Katsumi A., Yamazaki T., Sugiura I., Saito H.
      J. Biochem. 122:17-24(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/SvJ and C3H/An.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. "Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase."
      Fitzgerald M.L., Wang Z., Park P.W., Murphy G., Bernfield M.
      J. Cell Biol. 148:811-824(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SHEDDING.
    4. "Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration."
      Gao Y., Li M., Chen W., Simons M.
      J. Cell. Physiol. 184:373-379(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GIPC.
    5. "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5."
      Denhez F., Wilcox-Adelman S.A., Baciu P.C., Saoncella S., Lee S., French B., Neveu W., Goetinck P.F.
      J. Biol. Chem. 277:12270-12274(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NUDT16L1.

    Entry informationi

    Entry nameiSDC4_MOUSE
    AccessioniPrimary (citable) accession number: O35988
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3