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Protein

Syndecan-4

Gene

Sdc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity

GO - Molecular functioni

GO - Biological processi

  • glycosaminoglycan biosynthetic process Source: Reactome
  • inner ear receptor stereocilium organization Source: MGI
  • negative regulation of T cell proliferation Source: MGI
  • neural tube closure Source: MGI
  • positive regulation of exosomal secretion Source: MGI
  • positive regulation of extracellular exosome assembly Source: MGI
  • positive regulation of focal adhesion assembly Source: Ensembl
  • positive regulation of protein kinase activity Source: Ensembl
  • positive regulation of stress fiber assembly Source: Ensembl
  • regulation of fibroblast migration Source: UniProtKB
  • ureteric bud development Source: Ensembl
  • wound healing Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-3000170. Syndecan interactions.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-4
Short name:
SYND4
Alternative name(s):
Ryudocan core protein
Gene namesi
Name:Sdc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1349164. Sdc4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 145ExtracellularSequence analysisAdd BLAST122
Transmembranei146 – 170HelicalSequence analysisAdd BLAST25
Topological domaini171 – 198CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2062355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003351224 – 198Syndecan-4Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44O-linked (Xyl...) (heparan sulfate)By similarity1
Glycosylationi62O-linked (Xyl...) (heparan sulfate)Sequence analysis1
Glycosylationi64O-linked (Xyl...) (heparan sulfate)Sequence analysis1

Post-translational modificationi

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.1 Publication

Keywords - PTMi

Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

EPDiO35988.
PaxDbiO35988.
PeptideAtlasiO35988.
PRIDEiO35988.

PTM databases

iPTMnetiO35988.
PhosphoSitePlusiO35988.

Miscellaneous databases

PMAP-CutDBO35988.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in liver, kidney and lung.

Gene expression databases

BgeeiENSMUSG00000017009.
CleanExiMM_SDC4.
ExpressionAtlasiO35988. baseline and differential.
GenevisibleiO35988. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with CDCP1 and SDCBP (By similarity). Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PCOLCEQ151132EBI-9986850,EBI-8869614From a different organism.

Protein-protein interaction databases

IntActiO35988. 2 interactors.
STRINGi10090.ENSMUSP00000017153.

Structurei

3D structure databases

ProteinModelPortaliO35988.
SMRiO35988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiO35988.
KOiK16338.
OMAiQEPDDFE.
OrthoDBiEOG091G0OOE.
PhylomeDBiO35988.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPACLLAPL LLLLLGGFPL VPGESIRETE VIDPQDLLEG RYFSGALPDD
60 70 80 90 100
EDAGGSDDFE LSGSGDLDDT EEPRPFPEVI EPLVPLDNHI PENAQPGIRV
110 120 130 140 150
PSEPKELEEN EVIPKRAPSD VGDDMSNKVS MSSTAQGSNI FERTEVLAAL
160 170 180 190
IVGGVVGILF AVFLILLLVY RMKKKDEGSY DLGKKPIYKK APTNEFYA
Length:198
Mass (Da):21,482
Last modified:January 1, 1998 - v1
Checksum:i4246963EC6A25915
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89571 mRNA. Translation: BAA22135.1.
D89572 Genomic DNA. Translation: BAA22136.1.
BC005679 mRNA. Translation: AAH05679.1.
CCDSiCCDS17036.1.
PIRiJC5613.
RefSeqiNP_035651.1. NM_011521.2.
UniGeneiMm.3815.

Genome annotation databases

EnsembliENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009.
GeneIDi20971.
KEGGimmu:20971.
UCSCiuc008nuq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89571 mRNA. Translation: BAA22135.1.
D89572 Genomic DNA. Translation: BAA22136.1.
BC005679 mRNA. Translation: AAH05679.1.
CCDSiCCDS17036.1.
PIRiJC5613.
RefSeqiNP_035651.1. NM_011521.2.
UniGeneiMm.3815.

3D structure databases

ProteinModelPortaliO35988.
SMRiO35988.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35988. 2 interactors.
STRINGi10090.ENSMUSP00000017153.

Chemistry databases

ChEMBLiCHEMBL2062355.

PTM databases

iPTMnetiO35988.
PhosphoSitePlusiO35988.

Proteomic databases

EPDiO35988.
PaxDbiO35988.
PeptideAtlasiO35988.
PRIDEiO35988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017153; ENSMUSP00000017153; ENSMUSG00000017009.
GeneIDi20971.
KEGGimmu:20971.
UCSCiuc008nuq.1. mouse.

Organism-specific databases

CTDi6385.
MGIiMGI:1349164. Sdc4.

Phylogenomic databases

eggNOGiENOG410IXIG. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000263414.
HOVERGENiHBG004501.
InParanoidiO35988.
KOiK16338.
OMAiQEPDDFE.
OrthoDBiEOG091G0OOE.
PhylomeDBiO35988.
TreeFamiTF320463.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-3000170. Syndecan interactions.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiSdc4. mouse.
PMAP-CutDBO35988.
PROiO35988.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017009.
CleanExiMM_SDC4.
ExpressionAtlasiO35988. baseline and differential.
GenevisibleiO35988. MM.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDC4_MOUSE
AccessioniPrimary (citable) accession number: O35988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.