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Protein

Zinc finger Ran-binding domain-containing protein 2

Gene

Zranb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri9 – 4032RanBP2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri65 – 9430RanBP2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Ran-binding domain-containing protein 2
Alternative name(s):
Zinc finger protein 265
Zinc finger, splicing
Gene namesi
Name:Zranb2
Synonyms:Zfp265, Zis, Znf265
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61854. Zranb2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Zinc finger Ran-binding domain-containing protein 2PRO_0000066587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei18 – 181N6-acetyllysineBy similarity
Modified residuei54 – 541N6-acetyllysineBy similarity
Modified residuei92 – 921N6-acetyllysineBy similarity
Modified residuei120 – 1201PhosphoserineCombined sources
Modified residuei153 – 1531PhosphoserineCombined sources
Modified residuei181 – 1811PhosphoserineBy similarity
Modified residuei188 – 1881PhosphoserineCombined sources
Modified residuei193 – 1931PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO35986.
PRIDEiO35986.

PTM databases

iPTMnetiO35986.
PhosphoSiteiO35986.

Expressioni

Tissue specificityi

Expressed in kidney; more specifically in renal juxtaglomerular (JG) cells.

Gene expression databases

GenevisibleiO35986. RN.

Interactioni

Subunit structurei

Interacts with the C-terminal half of SNRP70/U1-70K, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.By similarity

Protein-protein interaction databases

BioGridi248628. 1 interaction.
STRINGi10116.ENSRNOP00000052134.

Structurei

3D structure databases

ProteinModelPortaliO35986.
SMRiO35986. Positions 1-40, 67-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 324174Required for nuclear targetingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 26265Arg/Ser-richAdd
BLAST

Domaini

The RanBP2-type zinc fingers mediate binding to RNA.By similarity

Sequence similaritiesi

Belongs to the ZRANB2 family.Curated
Contains 2 RanBP2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri9 – 4032RanBP2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri65 – 9430RanBP2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1995. Eukaryota.
ENOG4111QXA. LUCA.
HOGENOMiHOG000008684.
HOVERGENiHBG066285.
InParanoidiO35986.
OMAiDLWGDNE.
OrthoDBiEOG7ZD1XK.
PhylomeDBiO35986.
TreeFamiTF105996.

Family and domain databases

Gene3Di4.10.1060.10. 2 hits.
InterProiIPR017337. UCP037956_Znf_RanB2.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00641. zf-RanBP. 2 hits.
[Graphical view]
PIRSFiPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
SMARTiSM00547. ZnF_RBZ. 2 hits.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 2 hits.
PROSITEiPS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT
60 70 80 90 100
EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT
110 120 130 140 150
GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED
160 170 180 190 200
KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR
210 220 230 240 250
RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SHSGSREHSR
260 270 280 290 300
SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERDRKRSRS RPSSPAVRKK
310 320 330
RRTRSRSPER HHRSSSGSTH SGSRSSSKKK
Length:330
Mass (Da):37,350
Last modified:May 1, 2007 - v2
Checksum:i1FD8F01C7C644F21
GO

Sequence cautioni

The sequence AAC02295.1 differs from that shown. Reason: Frameshift at positions 236 and 316. Curated
The sequence AAC02296.1 differs from that shown. Reason: Frameshift at positions 236 and 316. Curated
The sequence AAC02297.1 differs from that shown. Reason: Frameshift at positions 236 and 316. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013965 mRNA. Translation: AAC02295.1. Frameshift.
AF013966 Genomic DNA. Translation: AAC02296.1. Frameshift.
AF013967 mRNA. Translation: AAC02297.1. Frameshift.
BC087012 mRNA. Translation: AAH87012.1.
RefSeqiNP_113804.1. NM_031616.1.
UniGeneiRn.11361.

Genome annotation databases

GeneIDi58821.
KEGGirno:58821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013965 mRNA. Translation: AAC02295.1. Frameshift.
AF013966 Genomic DNA. Translation: AAC02296.1. Frameshift.
AF013967 mRNA. Translation: AAC02297.1. Frameshift.
BC087012 mRNA. Translation: AAH87012.1.
RefSeqiNP_113804.1. NM_031616.1.
UniGeneiRn.11361.

3D structure databases

ProteinModelPortaliO35986.
SMRiO35986. Positions 1-40, 67-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248628. 1 interaction.
STRINGi10116.ENSRNOP00000052134.

PTM databases

iPTMnetiO35986.
PhosphoSiteiO35986.

Proteomic databases

PaxDbiO35986.
PRIDEiO35986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58821.
KEGGirno:58821.

Organism-specific databases

CTDi9406.
RGDi61854. Zranb2.

Phylogenomic databases

eggNOGiKOG1995. Eukaryota.
ENOG4111QXA. LUCA.
HOGENOMiHOG000008684.
HOVERGENiHBG066285.
InParanoidiO35986.
OMAiDLWGDNE.
OrthoDBiEOG7ZD1XK.
PhylomeDBiO35986.
TreeFamiTF105996.

Miscellaneous databases

NextBioi611368.
PROiO35986.

Gene expression databases

GenevisibleiO35986. RN.

Family and domain databases

Gene3Di4.10.1060.10. 2 hits.
InterProiIPR017337. UCP037956_Znf_RanB2.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00641. zf-RanBP. 2 hits.
[Graphical view]
PIRSFiPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
SMARTiSM00547. ZnF_RBZ. 2 hits.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 2 hits.
PROSITEiPS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zis: a developmentally regulated gene expressed in juxtaglomerular cells."
    Karginova E.A., Pentz E.S., Kazakova I.G., Norwood V.F., Carey R.M., Gomez R.A.
    Am. J. Physiol. 273:F731-F738(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-153 AND SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZRAB2_RAT
AccessioniPrimary (citable) accession number: O35986
Secondary accession number(s): A1A4C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: February 17, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.