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Protein

Pre-B-cell leukemia transcription factor 2

Gene

Pbx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi244 – 30663Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • embryonic limb morphogenesis Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • proximal/distal pattern formation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 2
Alternative name(s):
Homeobox protein PBX2
Gene namesi
Name:Pbx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1341793. Pbx2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Pre-B-cell leukemia transcription factor 2PRO_0000049238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei136 – 1361PhosphoserineBy similarity
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei330 – 3301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35984.
PaxDbiO35984.
PRIDEiO35984.

PTM databases

PhosphoSiteiO35984.

Expressioni

Gene expression databases

BgeeiO35984.
CleanExiMM_PBX2.
ExpressionAtlasiO35984. baseline and differential.
GenevisibleiO35984. MM.

Interactioni

Subunit structurei

Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi202038. 8 interactions.
IntActiO35984. 1 interaction.
STRINGi10090.ENSMUSP00000040464.

Structurei

3D structure databases

ProteinModelPortaliO35984.
SMRiO35984. Positions 244-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 114Poly-Pro
Compositional biasi137 – 1459Poly-Ala

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG248144.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiO35984.
KOiK15609.
OMAiIRANGGW.
PhylomeDBiO35984.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDERLLGPPP PGGGRGGLGL VGAEPGGPGE PPGGGDPGGG SGGVPGGRGK
60 70 80 90 100
QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL
110 120 130 140 150
SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV
160 170 180 190 200
SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT
210 220 230 240 250
RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN
260 270 280 290 300
FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI
310 320 330 340 350
RYKKNIGKFQ EEANIYAVKT AVSVAQGGHS RTSSPTPPSS AGSGGSFNLS
360 370 380 390 400
GSGDMFLGMP GLNGDSYPAS QVESLRHSMG PGSYGDNIGG GQIYSPREIR
410 420 430
ANGGWQEAVT PSSVTSPTEG PGSVHSDTSN
Length:430
Mass (Da):45,809
Last modified:January 1, 1998 - v1
Checksum:iCB6B71A6FE207E8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020198 mRNA. Translation: AAB71193.1.
AF030001 Genomic DNA. Translation: AAB82006.1.
BC010287 mRNA. Translation: AAH10287.1.
BC062147 mRNA. Translation: AAH62147.1.
CCDSiCCDS28648.1.
PIRiT09061.
RefSeqiNP_059491.1. NM_017463.2.
UniGeneiMm.390957.

Genome annotation databases

EnsembliENSMUST00000038149; ENSMUSP00000040464; ENSMUSG00000034673.
GeneIDi18515.
KEGGimmu:18515.
UCSCiuc008ccv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020198 mRNA. Translation: AAB71193.1.
AF030001 Genomic DNA. Translation: AAB82006.1.
BC010287 mRNA. Translation: AAH10287.1.
BC062147 mRNA. Translation: AAH62147.1.
CCDSiCCDS28648.1.
PIRiT09061.
RefSeqiNP_059491.1. NM_017463.2.
UniGeneiMm.390957.

3D structure databases

ProteinModelPortaliO35984.
SMRiO35984. Positions 244-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202038. 8 interactions.
IntActiO35984. 1 interaction.
STRINGi10090.ENSMUSP00000040464.

PTM databases

PhosphoSiteiO35984.

Proteomic databases

MaxQBiO35984.
PaxDbiO35984.
PRIDEiO35984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038149; ENSMUSP00000040464; ENSMUSG00000034673.
GeneIDi18515.
KEGGimmu:18515.
UCSCiuc008ccv.1. mouse.

Organism-specific databases

CTDi5089.
MGIiMGI:1341793. Pbx2.

Phylogenomic databases

eggNOGiNOG248144.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiO35984.
KOiK15609.
OMAiIRANGGW.
PhylomeDBiO35984.
TreeFamiTF314340.

Miscellaneous databases

NextBioi294258.
PROiO35984.
SOURCEiSearch...

Gene expression databases

BgeeiO35984.
CleanExiMM_PBX2.
ExpressionAtlasiO35984. baseline and differential.
GenevisibleiO35984. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Liu Y., MacDonald R.J.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Limb and Mammary gland.
  4. "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells."
    Shen W.-F., Rozenfeld S., Kwong A., Koemueves L.G., Lawrence H.J., Largman C.
    Mol. Cell. Biol. 19:3051-3061(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOXA9 AND MEIS1.

Entry informationi

Entry nameiPBX2_MOUSE
AccessioniPrimary (citable) accession number: O35984
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 22, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.