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O35984

- PBX2_MOUSE

UniProt

O35984 - PBX2_MOUSE

Protein

Pre-B-cell leukemia transcription factor 2

Gene

Pbx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi244 – 30663Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. embryonic limb morphogenesis Source: MGI
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    3. proximal/distal pattern formation Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-B-cell leukemia transcription factor 2
    Alternative name(s):
    Homeobox protein PBX2
    Gene namesi
    Name:Pbx2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1341793. Pbx2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Pre-B-cell leukemia transcription factor 2PRO_0000049238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511PhosphoserineBy similarity
    Modified residuei330 – 3301PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO35984.
    PaxDbiO35984.
    PRIDEiO35984.

    PTM databases

    PhosphoSiteiO35984.

    Expressioni

    Gene expression databases

    ArrayExpressiO35984.
    BgeeiO35984.
    CleanExiMM_PBX2.
    GenevestigatoriO35984.

    Interactioni

    Subunit structurei

    Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi202038. 8 interactions.
    IntActiO35984. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO35984.
    SMRiO35984. Positions 244-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8 – 114Poly-Pro
    Compositional biasi137 – 1459Poly-Ala

    Sequence similaritiesi

    Belongs to the TALE/PBX homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG248144.
    HOGENOMiHOG000266972.
    HOVERGENiHBG000122.
    InParanoidiO35984.
    KOiK15609.
    OMAiGQIYSPR.
    PhylomeDBiO35984.
    TreeFamiTF314340.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR005542. PBX.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03792. PBC. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35984-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDERLLGPPP PGGGRGGLGL VGAEPGGPGE PPGGGDPGGG SGGVPGGRGK    50
    QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL 100
    SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV 150
    SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT 200
    RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN 250
    FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 300
    RYKKNIGKFQ EEANIYAVKT AVSVAQGGHS RTSSPTPPSS AGSGGSFNLS 350
    GSGDMFLGMP GLNGDSYPAS QVESLRHSMG PGSYGDNIGG GQIYSPREIR 400
    ANGGWQEAVT PSSVTSPTEG PGSVHSDTSN 430
    Length:430
    Mass (Da):45,809
    Last modified:January 1, 1998 - v1
    Checksum:iCB6B71A6FE207E8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020198 mRNA. Translation: AAB71193.1.
    AF030001 Genomic DNA. Translation: AAB82006.1.
    BC010287 mRNA. Translation: AAH10287.1.
    BC062147 mRNA. Translation: AAH62147.1.
    CCDSiCCDS28648.1.
    PIRiT09061.
    RefSeqiNP_059491.1. NM_017463.2.
    UniGeneiMm.390957.

    Genome annotation databases

    EnsembliENSMUST00000038149; ENSMUSP00000040464; ENSMUSG00000034673.
    GeneIDi18515.
    KEGGimmu:18515.
    UCSCiuc008ccv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020198 mRNA. Translation: AAB71193.1 .
    AF030001 Genomic DNA. Translation: AAB82006.1 .
    BC010287 mRNA. Translation: AAH10287.1 .
    BC062147 mRNA. Translation: AAH62147.1 .
    CCDSi CCDS28648.1.
    PIRi T09061.
    RefSeqi NP_059491.1. NM_017463.2.
    UniGenei Mm.390957.

    3D structure databases

    ProteinModelPortali O35984.
    SMRi O35984. Positions 244-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202038. 8 interactions.
    IntActi O35984. 1 interaction.

    PTM databases

    PhosphoSitei O35984.

    Proteomic databases

    MaxQBi O35984.
    PaxDbi O35984.
    PRIDEi O35984.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038149 ; ENSMUSP00000040464 ; ENSMUSG00000034673 .
    GeneIDi 18515.
    KEGGi mmu:18515.
    UCSCi uc008ccv.1. mouse.

    Organism-specific databases

    CTDi 5089.
    MGIi MGI:1341793. Pbx2.

    Phylogenomic databases

    eggNOGi NOG248144.
    HOGENOMi HOG000266972.
    HOVERGENi HBG000122.
    InParanoidi O35984.
    KOi K15609.
    OMAi GQIYSPR.
    PhylomeDBi O35984.
    TreeFami TF314340.

    Miscellaneous databases

    NextBioi 294258.
    PROi O35984.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35984.
    Bgeei O35984.
    CleanExi MM_PBX2.
    Genevestigatori O35984.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR005542. PBX.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03792. PBC. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Liu Y., MacDonald R.J.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Limb and Mammary gland.
    4. "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells."
      Shen W.-F., Rozenfeld S., Kwong A., Koemueves L.G., Lawrence H.J., Largman C.
      Mol. Cell. Biol. 19:3051-3061(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOXA9 AND MEIS1.

    Entry informationi

    Entry nameiPBX2_MOUSE
    AccessioniPrimary (citable) accession number: O35984
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3