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O35984 (PBX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-B-cell leukemia transcription factor 2
Alternative name(s):
Homeobox protein PBX2
Gene names
Name:Pbx2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 By similarity.

Subunit structure

Forms heterodimers with MEIS1 and heterotrimers with MEIS1 and HOXA9. Interacts with PBXIP1 By similarity. Ref.4

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the TALE/PBX homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Pre-B-cell leukemia transcription factor 2
PRO_0000049238

Regions

DNA binding244 – 30663Homeobox; TALE-type
Compositional bias8 – 114Poly-Pro
Compositional bias137 – 1459Poly-Ala

Amino acid modifications

Modified residue1511Phosphoserine By similarity
Modified residue3301Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O35984 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CB6B71A6FE207E8D

FASTA43045,809
        10         20         30         40         50         60 
MDERLLGPPP PGGGRGGLGL VGAEPGGPGE PPGGGDPGGG SGGVPGGRGK QDIGDILQQI 

        70         80         90        100        110        120 
MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL SIRSSQEEEP VDPQLMRLDN 

       130        140        150        160        170        180 
MLLAEGVAGP EKGGGSAAAA AAAAASGGGV SPDNSIEHSD YRSKLAQIRH IYHSELEKYE 

       190        200        210        220        230        240 
QACNEFTTHV MNLLREQSRT RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR 

       250        260        270        280        290        300 
FLDARRKRRN FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 

       310        320        330        340        350        360 
RYKKNIGKFQ EEANIYAVKT AVSVAQGGHS RTSSPTPPSS AGSGGSFNLS GSGDMFLGMP 

       370        380        390        400        410        420 
GLNGDSYPAS QVESLRHSMG PGSYGDNIGG GQIYSPREIR ANGGWQEAVT PSSVTSPTEG 

       430 
PGSVHSDTSN 

« Hide

References

« Hide 'large scale' references
[1]Liu Y., MacDonald R.J.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Limb and Mammary gland.
[4]"HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells."
Shen W.-F., Rozenfeld S., Kwong A., Koemueves L.G., Lawrence H.J., Largman C.
Mol. Cell. Biol. 19:3051-3061(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOXA9 AND MEIS1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF020198 mRNA. Translation: AAB71193.1.
AF030001 Genomic DNA. Translation: AAB82006.1.
BC010287 mRNA. Translation: AAH10287.1.
BC062147 mRNA. Translation: AAH62147.1.
CCDSCCDS28648.1.
PIRT09061.
RefSeqNP_059491.1. NM_017463.2.
UniGeneMm.390957.

3D structure databases

ProteinModelPortalO35984.
SMRO35984. Positions 244-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202038. 8 interactions.
IntActO35984. 1 interaction.

PTM databases

PhosphoSiteO35984.

Proteomic databases

MaxQBO35984.
PaxDbO35984.
PRIDEO35984.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038149; ENSMUSP00000040464; ENSMUSG00000034673.
GeneID18515.
KEGGmmu:18515.
UCSCuc008ccv.1. mouse.

Organism-specific databases

CTD5089.
MGIMGI:1341793. Pbx2.

Phylogenomic databases

eggNOGNOG248144.
HOGENOMHOG000266972.
HOVERGENHBG000122.
InParanoidO35984.
KOK15609.
OMAGQIYSPR.
PhylomeDBO35984.
TreeFamTF314340.

Gene expression databases

ArrayExpressO35984.
BgeeO35984.
CleanExMM_PBX2.
GenevestigatorO35984.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294258.
PROO35984.
SOURCESearch...

Entry information

Entry namePBX2_MOUSE
AccessionPrimary (citable) accession number: O35984
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot