Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

GDNF family receptor alpha 2

Gene

Gfra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-8853659. RET signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
GDNF family receptor alpha 2Imported
Submitted name:
Glial cell line derived neurotrophic factor family receptor alpha 2Imported
Submitted name:
Glial cell line-derived neurotrophic factor receptor-betaImported
Submitted name:
RET ligand 2Imported
Gene namesi
Name:Gfra2Imported
Synonyms:GDNFR-betaImported, RETL2Imported
ORF Names:rCG_37079Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi61809. Gfra2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500970842722 – 464Sequence analysisAdd BLAST443

Expressioni

Gene expression databases

BgeeiENSRNOG00000014010.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 117GDNFInterPro annotationAdd BLAST78
Domaini161 – 241GDNFInterPro annotationAdd BLAST81
Domaini251 – 347GDNFInterPro annotationAdd BLAST97

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IU4F. Eukaryota.
ENOG410XPTA. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000008695.
HOVERGENiHBG051725.
OMAiSLCRTDH.
OrthoDBiEOG091G087B.
TreeFamiTF331647.

Family and domain databases

InterProiView protein in InterPro
IPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003504. GDNF_rcpt_a2.
IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
PfamiView protein in Pfam
PF02351. GDNF. 3 hits.
PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
PRINTSiPR01318. GDNFRALPHA2.
PR01316. GDNFRECEPTOR.
SMARTiView protein in SMART
SM00907. GDNF. 3 hits.

Sequencei

Sequence statusi: Complete.

O35977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILANAFCLF FFLDETLRSL ASPSSLQGSE LHGWRPQVDC VRANELCAAE
60 70 80 90 100
SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK
110 120 130 140 150
KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGT
160 170 180 190 200
DPAVSTKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC
210 220 230 240 250
HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN
260 270 280 290 300
CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM
310 320 330 340 350
IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLR DFTENPCLRN
360 370 380 390 400
AIQAFGNGTD VNMSPKGPSL PATQAPRVEK TPSLPDDLSD STSLGTSVIT
410 420 430 440 450
TCTSIQEQGL KANNSKELSM CFTELTTNIS PGSKKVIKLN SGSSRARLSA
460
ALTALPLLML TLAL
Length:464
Mass (Da):51,669
Last modified:January 1, 1998 - v1
Checksum:i81168301BE50D6CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018331 Genomic DNA. No translation available.
AF005226 mRNA. Translation: AAB62247.1.
U97143 mRNA. Translation: AAC53301.1.
CH473951 Genomic DNA. Translation: EDM02244.1.
RefSeqiNP_036882.1. NM_012750.1.
UniGeneiRn.90137.

Genome annotation databases

EnsembliENSRNOT00000019222; ENSRNOP00000019222; ENSRNOG00000014010.
GeneIDi25136.
KEGGirno:25136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018331 Genomic DNA. No translation available.
AF005226 mRNA. Translation: AAB62247.1.
U97143 mRNA. Translation: AAC53301.1.
CH473951 Genomic DNA. Translation: EDM02244.1.
RefSeqiNP_036882.1. NM_012750.1.
UniGeneiRn.90137.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019222.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019222; ENSRNOP00000019222; ENSRNOG00000014010.
GeneIDi25136.
KEGGirno:25136.

Organism-specific databases

CTDi2675.
RGDi61809. Gfra2.

Phylogenomic databases

eggNOGiENOG410IU4F. Eukaryota.
ENOG410XPTA. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000008695.
HOVERGENiHBG051725.
OMAiSLCRTDH.
OrthoDBiEOG091G087B.
TreeFamiTF331647.

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-8853659. RET signaling.

Gene expression databases

BgeeiENSRNOG00000014010.

Family and domain databases

InterProiView protein in InterPro
IPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR003504. GDNF_rcpt_a2.
IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
PfamiView protein in Pfam
PF02351. GDNF. 3 hits.
PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
PRINTSiPR01318. GDNFRALPHA2.
PR01316. GDNFRECEPTOR.
SMARTiView protein in SMART
SM00907. GDNF. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiO35977_RAT
AccessioniPrimary (citable) accession number: O35977
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 15, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.