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Protein

GDNF family receptor alpha

Gene

Gfra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotationImported

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-8853659. RET signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alphaUniRule annotation
Gene namesi
Name:Gfra2Imported
Synonyms:GDNFR-betaImported, RETL2Imported
ORF Names:rCG_37079Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi61809. Gfra2.

Subcellular locationi

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Signal peptidei1 – 21UniRule annotationAdd BLAST21
    ChainiPRO_501183592622 – 464GDNF family receptor alphaUniRule annotationAdd BLAST443

    Expressioni

    Gene expression databases

    BgeeiENSRNOG00000014010.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000019222.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini40 – 117GDNFInterPro annotationAdd BLAST78
    Domaini161 – 241GDNFInterPro annotationAdd BLAST81
    Domaini251 – 347GDNFInterPro annotationAdd BLAST97

    Sequence similaritiesi

    Belongs to the GDNFR family.UniRule annotation

    Keywords - Domaini

    SignalUniRule annotation

    Phylogenomic databases

    eggNOGiENOG410IU4F. Eukaryota.
    ENOG410XPTA. LUCA.
    GeneTreeiENSGT00550000074579.
    HOGENOMiHOG000008695.
    HOVERGENiHBG051725.
    OMAiSLCRTDH.
    OrthoDBiEOG091G087B.
    TreeFamiTF331647.

    Family and domain databases

    InterProiView protein in InterPro
    IPR016017. GDNF/GAS1.
    IPR037193. GDNF_alpha.
    IPR003438. GDNF_rcpt.
    IPR003504. GDNF_rcpt_a2.
    IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
    PANTHERiPTHR10269. PTHR10269. 1 hit.
    PfamiView protein in Pfam
    PF02351. GDNF. 3 hits.
    PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
    PRINTSiPR01318. GDNFRALPHA2.
    PR01316. GDNFRECEPTOR.
    SMARTiView protein in SMART
    SM00907. GDNF. 3 hits.
    SUPFAMiSSF110035. SSF110035. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35977-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MILANAFCLF FFLDETLRSL ASPSSLQGSE LHGWRPQVDC VRANELCAAE
    60 70 80 90 100
    SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK
    110 120 130 140 150
    KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGT
    160 170 180 190 200
    DPAVSTKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC
    210 220 230 240 250
    HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN
    260 270 280 290 300
    CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM
    310 320 330 340 350
    IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLR DFTENPCLRN
    360 370 380 390 400
    AIQAFGNGTD VNMSPKGPSL PATQAPRVEK TPSLPDDLSD STSLGTSVIT
    410 420 430 440 450
    TCTSIQEQGL KANNSKELSM CFTELTTNIS PGSKKVIKLN SGSSRARLSA
    460
    ALTALPLLML TLAL
    Length:464
    Mass (Da):51,669
    Last modified:January 1, 1998 - v1
    Checksum:i81168301BE50D6CC
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AABR07018331 Genomic DNA. No translation available.
    AF005226 mRNA. Translation: AAB62247.1.
    U97143 mRNA. Translation: AAC53301.1.
    CH473951 Genomic DNA. Translation: EDM02244.1.
    RefSeqiNP_036882.1. NM_012750.1.
    UniGeneiRn.90137.

    Genome annotation databases

    EnsembliENSRNOT00000019222; ENSRNOP00000019222; ENSRNOG00000014010.
    GeneIDi25136.
    KEGGirno:25136.

    Similar proteinsi

    Entry informationi

    Entry nameiO35977_RAT
    AccessioniPrimary (citable) accession number: O35977
    Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: January 31, 2018
    This is version 114 of the entry and version 1 of the sequence. See complete history.
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported