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Protein

GDNF family receptor alpha

Gene

Gfra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotationImported

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-8853659. RET signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alphaUniRule annotation
Gene namesi
Name:Gfra2Imported
Synonyms:GDNFR-betaImported, RETL2Imported
ORF Names:rCG_37079Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi61809. Gfra2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_501398913022 – 464GDNF family receptor alphaUniRule annotationAdd BLAST443

Expressioni

Gene expression databases

BgeeiENSRNOG00000014010.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 117GDNFInterPro annotationAdd BLAST78
Domaini161 – 241GDNFInterPro annotationAdd BLAST81
Domaini251 – 347GDNFInterPro annotationAdd BLAST97

Sequence similaritiesi

Belongs to the GDNFR family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IU4F. Eukaryota.
ENOG410XPTA. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000008695.
HOVERGENiHBG051725.
OMAiSLCRTDH.
OrthoDBiEOG091G087B.
TreeFamiTF331647.

Family and domain databases

InterProiView protein in InterPro
IPR016017. GDNF/GAS1.
IPR037193. GDNF_alpha.
IPR003438. GDNF_rcpt.
IPR003504. GDNF_rcpt_a2.
IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
PANTHERiPTHR10269. PTHR10269. 1 hit.
PfamiView protein in Pfam
PF02351. GDNF. 3 hits.
PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
PRINTSiPR01318. GDNFRALPHA2.
PR01316. GDNFRECEPTOR.
SMARTiView protein in SMART
SM00907. GDNF. 3 hits.
SUPFAMiSSF110035. SSF110035. 1 hit.

Sequencei

Sequence statusi: Complete.

O35977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILANAFCLF FFLDETLRSL ASPSSLQGSE LHGWRPQVDC VRANELCAAE
60 70 80 90 100
SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK
110 120 130 140 150
KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGT
160 170 180 190 200
DPAVSTKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC
210 220 230 240 250
HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN
260 270 280 290 300
CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM
310 320 330 340 350
IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLR DFTENPCLRN
360 370 380 390 400
AIQAFGNGTD VNMSPKGPSL PATQAPRVEK TPSLPDDLSD STSLGTSVIT
410 420 430 440 450
TCTSIQEQGL KANNSKELSM CFTELTTNIS PGSKKVIKLN SGSSRARLSA
460
ALTALPLLML TLAL
Length:464
Mass (Da):51,669
Last modified:January 1, 1998 - v1
Checksum:i81168301BE50D6CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018331 Genomic DNA. No translation available.
AF005226 mRNA. Translation: AAB62247.1.
U97143 mRNA. Translation: AAC53301.1.
CH473951 Genomic DNA. Translation: EDM02244.1.
RefSeqiNP_036882.1. NM_012750.1.
UniGeneiRn.90137.

Genome annotation databases

EnsembliENSRNOT00000019222; ENSRNOP00000019222; ENSRNOG00000014010.
GeneIDi25136.
KEGGirno:25136.

Similar proteinsi

Entry informationi

Entry nameiO35977_RAT
AccessioniPrimary (citable) accession number: O35977
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported