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O35973

- PER1_MOUSE

UniProt

O35973 - PER1_MOUSE

Protein

Period circadian protein homolog 1

Gene

Per1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.9 Publications

    GO - Molecular functioni

    1. chromatin DNA binding Source: UniProtKB
    2. E-box binding Source: Ensembl
    3. kinase binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    6. signal transducer activity Source: InterPro
    7. transcription factor binding Source: UniProtKB
    8. transcription factor binding transcription factor activity Source: BHF-UCL
    9. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. circadian regulation of gene expression Source: UniProtKB
    2. circadian regulation of translation Source: UniProtKB
    3. circadian rhythm Source: UniProtKB
    4. entrainment of circadian clock by photoperiod Source: UniProtKB
    5. histone H3 acetylation Source: UniProtKB
    6. histone H3 deacetylation Source: UniProtKB
    7. negative regulation of glucocorticoid receptor signaling pathway Source: UniProtKB
    8. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    9. negative regulation of JNK cascade Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: UniProtKB
    11. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    12. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    13. posttranscriptional regulation of gene expression Source: UniProtKB
    14. regulation of circadian rhythm Source: UniProtKB
    15. regulation of cytokine production involved in inflammatory response Source: UniProtKB
    16. regulation of hair cycle Source: UniProtKB
    17. regulation of p38MAPK cascade Source: UniProtKB
    18. regulation of sodium ion transport Source: UniProtKB
    19. response to cAMP Source: UniProtKB
    20. response to light stimulus Source: BHF-UCL
    21. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_24972. Circadian Clock.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Period circadian protein homolog 1
    Short name:
    mPER1
    Alternative name(s):
    Circadian clock protein PERIOD 1
    Circadian pacemaker protein Rigui
    Gene namesi
    Name:Per1
    Synonyms:Per, Rigui
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1098283. Per1.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Animals show disrupted circadian behavior. The prolongation of light exposure produces larger phase delay of behavioral rhythm compared to wild-types. Double knocknouts for PER2 and PER1 show an abrupt loss of rhythmicity immediately upon transfer to exprosure to constant darkness. Animals have largely affected the water intake (polydipsia) and urine volume (polyuria).3 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi267 – 2671Y → E: No effect on homodimerization. Abolishes homodimerization; when associated with E-444. 1 Publication
    Mutagenesisi444 – 4441F → E: Reduces homodimerization. Abolishes homodimerization; when associated with E-267. 1 Publication
    Mutagenesisi448 – 4481W → E: Abolishes homodimerization. 1 Publication
    Mutagenesisi661 – 6611S → A: Reduced phosphorylation. No nuclear entry of PER1, CRY1 nor CKSN1E; when associated with A-663.
    Mutagenesisi663 – 6631S → A: Reduced phosphorylation. No nuclear entry PER1, CRY1 nor CKSN1E; when associated with A-661.
    Mutagenesisi831 – 8333HCR → ACA: No effect on nuclear import.
    Mutagenesisi835 – 8384KAKR → AAKA: Abolishes nuclear accumulation.
    Mutagenesisi902 – 91514TSVSP…SPLVT → AAVAPAAFPAPLVA: No effect on nuclear import. Add
    BLAST

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12911291Period circadian protein homolog 1PRO_0000162628Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei121 – 1211Phosphothreonine; by CSNK1ESequence Analysis
    Modified residuei122 – 1221Phosphoserine; by CSNK1ESequence Analysis
    Modified residuei126 – 1261Phosphoserine; by CSNK1ESequence Analysis
    Modified residuei661 – 6611Phosphoserine1 Publication
    Modified residuei663 – 6631Phosphoserine1 Publication
    Modified residuei704 – 7041PhosphoserineBy similarity
    Modified residuei815 – 8151PhosphoserineBy similarity
    Modified residuei978 – 9781PhosphoserineBy similarity
    Modified residuei979 – 9791PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on serine residues by CSNK1D, CSNK1E and probably also by CSNK1G2. Phosphorylation by CSNK1D or CSNK1E promotes nuclear location of PER proteins as well as ubiquitination and subsequent degradation. May be dephosphorylated by PP1.1 Publication
    Ubiquitinated; requires phosphorylation by CSNK1E and interaction with BTRC and FBXW11.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO35973.
    PRIDEiO35973.

    PTM databases

    PhosphoSiteiO35973.

    Expressioni

    Tissue specificityi

    In brain, highest expression is observed in the SCN. Highly expressed in the pyramidal cell layer of the piriform cortex, the periventricular part of the caudate-putamen, many thalamic nuclei, and the granular layer of the cerebellar cortex. Weaker expression is detected in most area of the brain, including cortical and non cortical structures. Expression but no oscillations occurs in the glomerular and mitral cell layers of the olfactory bulb, the internal granular layer of the cerebellum, the cornu ammonis and dentate gyrus of the hyppocampus, the cerebral and piriform cortices. Expressed in the renal cortex (at protein level). Also found in heart, brain, bladder, lumbar spinal cord, spleen, lung, liver, skeletal muscle and testis.7 Publications

    Developmental stagei

    Expressed in the suprachiasmatic nucleus (SCN) during late fetal and early neonatal life.

    Inductioni

    In the suprachiasmatic nucleus (SCN), behaves like a day-type oscillator, with maximum expression during the light period. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between PER1 and PER2 oscillations. The expression rhythms appear to originate from retina. In liver, peak levels at CT9. In the SCN, levels increase by light exposure during subjective night. Circadian oscillations also observed in skeletal muscle, bladder, lumbar spinal cord and liver but not in testis.7 Publications

    Gene expression databases

    ArrayExpressiO35973.
    BgeeiO35973.
    CleanExiMM_PER1.
    GenevestigatoriO35973.

    Interactioni

    Subunit structurei

    Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interacts with ARNTL and clock. Interacts with GPRASP1. Interacts (phosphorylated) with BTRC and FBXW11; the interactions trigger proteasomal degradation. Interacts with NONO, WDR5 and SFPQ.10 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TimelessQ9R1X43EBI-1266764,EBI-1793117

    Protein-protein interaction databases

    BioGridi202111. 24 interactions.
    DIPiDIP-38519N.
    IntActiO35973. 8 interactions.

    Structurei

    Secondary structure

    1
    1291
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi198 – 2003
    Helixi202 – 21211
    Beta strandi217 – 2259
    Turni226 – 2283
    Beta strandi230 – 2345
    Helixi237 – 2426
    Turni247 – 2515
    Helixi254 – 2574
    Helixi260 – 26910
    Turni272 – 2743
    Beta strandi297 – 3015
    Beta strandi314 – 32512
    Beta strandi334 – 34310
    Beta strandi347 – 3515
    Helixi355 – 3573
    Beta strandi359 – 3646
    Beta strandi369 – 3735
    Helixi377 – 3815
    Helixi385 – 3884
    Helixi393 – 3964
    Helixi399 – 4013
    Helixi402 – 41211
    Beta strandi415 – 4173
    Beta strandi425 – 4284
    Beta strandi430 – 4323
    Beta strandi434 – 4385
    Beta strandi440 – 4456
    Turni447 – 4493
    Beta strandi451 – 46313
    Helixi485 – 49814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DJ2X-ray2.75A/B/C/D191-502[»]
    ProteinModelPortaliO35973.
    SMRiO35973. Positions 196-502.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini208 – 27568PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini348 – 41467PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini422 – 46544PACAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 151151Interaction with BTRCBy similarityAdd
    BLAST
    Regioni596 – 815220Required for phosphorylation by CSNK1EAdd
    BLAST
    Regioni1148 – 1291144CRY binding domainAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi138 – 14710Nuclear export signal 1By similarity
    Motifi489 – 49810Nuclear export signal 3
    Motifi824 – 84017Nuclear localization signal1 PublicationAdd
    BLAST
    Motifi981 – 9888Nuclear export signal 2By similarity
    Motifi1042 – 10465LXXLL

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi49 – 12981Ser-richAdd
    BLAST
    Compositional biasi653 – 6564Poly-Ser
    Compositional biasi841 – 8444Poly-His
    Compositional biasi847 – 971125Pro-richAdd
    BLAST
    Compositional biasi1029 – 110375Ser-richAdd
    BLAST
    Compositional biasi1224 – 127754Gly-richAdd
    BLAST
    Compositional biasi1270 – 12734Poly-Glu

    Sequence similaritiesi

    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG253593.
    GeneTreeiENSGT00510000046467.
    HOVERGENiHBG008167.
    InParanoidiB1ASX0.
    KOiK02633.
    OMAiELGAVHS.
    TreeFamiTF318445.

    Family and domain databases

    InterProiIPR001610. PAC.
    IPR000014. PAS.
    IPR022728. Period_circadian-like_C.
    [Graphical view]
    PfamiPF12114. Period_C. 1 hit.
    [Graphical view]
    SMARTiSM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    PROSITEiPS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGPLEGADG GGDPRPGEPF CPGGVPSPGA PQHRPCPGPS LADDTDANSN     50
    GSSGNESNGP ESRGASQRSS HSSSSGNGKD SALLETTESS KSTNSQSPSP 100
    PSSSIAYSLL SASSEQDNPS TSGCSSEQSA RARTQKELMT ALRELKLRLP 150
    PERRGKGRSG TLATLQYALA CVKQVQANQE YYQQWSLEEG EPCAMDMSTY 200
    TLEELEHITS EYTLRNQDTF SVAVSFLTGR IVYISEQAGV LLRCKRDVFR 250
    GARFSELLAP QDVGVFYGST TPSRLPTWGT GTSAGSGLKD FTQEKSVFCR 300
    IRGGPDRDPG PRYQPFRLTP YVTKIRVSDG APAQPCCLLI AERIHSGYEA 350
    PRIPPDKRIF TTRHTPSCLF QDVDERAAPL LGYLPQDLLG APVLLFLHPE 400
    DRPLMLAIHK KILQLAGQPF DHSPIRFCAR NGEYVTMDTS WAGFVHPWSR 450
    KVAFVLGRHK VRTAPLNEDV FTPPAPSPAP SLDSDIQELS EQIHRLLLQP 500
    VHSSSPTGLC GVGPLMSPGP LHSPGSSSDS NGGDAEGPGP PAPVTFQQIC 550
    KDVHLVKHQG QQLFIESRAK PPPRPRLLAT GTFKAKVLPC QSPNPELEVA 600
    PVPDQASLAL APEEPERKET SGCSYQQINC LDSILRYLES CNIPSTTKRK 650
    CASSSSYTAS SASDDDKQRA GPVPVGAKKD PSSAMLSGEG ATPRKEPVVG 700
    GTLSPLALAN KAESVVSVTS QCSFSSTIVH VGDKKPPESD IIMMEDLPGL 750
    APGPAPSPAP SPTVAPDPTP DAYRPVGLTK AVLSLHTQKE EQAFLNRFRD 800
    LGRLRGLDTS SVAPSAPGCH HGPIPPGRRH HCRSKAKRSR HHHHQTPRPE 850
    TPCYVSHPSP VPSSGPWPPP PATTPFPAMV QPYPLPVFSP RGGPQPLPPA 900
    PTSVSPATFP SPLVTPMVAL VLPNYLFPTP PSYPYGVSQA PVEGPPTPAS 950
    HSPSPSLPPP PLSPPHRPDS PLFNSRCSSP LQLNLLQLEE SPRTEGGAAA 1000
    GGPGSSAGPL PPSEETAEPE ARLVEVTESS NQDALSGSSD LLELLLQEDS 1050
    RSGTGSAASG SLGSGLGSGS GSGSHEGGST SASITRSSQS SHTSKYFGSI 1100
    DSSEAEAGAA RARTEPGDQV IKCVLQDPIW LLMANADQRV MMTYQVPSRD 1150
    AASVLKQDRE RLRAMQKQQP RFSEDQRREL GAVHSWVRKG QLPRALDVTA 1200
    CVDCGSSVQD PGHSDDPLFS ELDGLGLEPM EEGGGEGGGC GVGGGGGDGG 1250
    EEAQTQIGAK GSSSQDSAME EEEQGGGSSS PALPAEENST S 1291
    Length:1,291
    Mass (Da):136,373
    Last modified:July 27, 2011 - v2
    Checksum:i77FB9BC71EDF31A6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1199 – 11991T → M in AAC53355. (PubMed:9323128)Curated
    Sequence conflicti1199 – 11991T → M in BAA22634. (PubMed:9333243)Curated
    Sequence conflicti1199 – 11991T → M in BAA94086. (PubMed:10857746)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022992 mRNA. Translation: AAC53355.1.
    AB002108 mRNA. Translation: BAA22634.1.
    AB030818 Genomic DNA. Translation: BAA94086.1.
    AL645527 Genomic DNA. Translation: CAI35245.1.
    CCDSiCCDS24882.1.
    PIRiT00019.
    RefSeqiNP_001152839.1. NM_001159367.1.
    NP_035195.2. NM_011065.4.
    XP_006532543.1. XM_006532480.1.
    UniGeneiMm.7373.

    Genome annotation databases

    EnsembliENSMUST00000021271; ENSMUSP00000021271; ENSMUSG00000020893.
    ENSMUST00000166748; ENSMUSP00000132635; ENSMUSG00000020893.
    GeneIDi18626.
    KEGGimmu:18626.
    UCSCiuc007jpg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022992 mRNA. Translation: AAC53355.1 .
    AB002108 mRNA. Translation: BAA22634.1 .
    AB030818 Genomic DNA. Translation: BAA94086.1 .
    AL645527 Genomic DNA. Translation: CAI35245.1 .
    CCDSi CCDS24882.1.
    PIRi T00019.
    RefSeqi NP_001152839.1. NM_001159367.1.
    NP_035195.2. NM_011065.4.
    XP_006532543.1. XM_006532480.1.
    UniGenei Mm.7373.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DJ2 X-ray 2.75 A/B/C/D 191-502 [» ]
    ProteinModelPortali O35973.
    SMRi O35973. Positions 196-502.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202111. 24 interactions.
    DIPi DIP-38519N.
    IntActi O35973. 8 interactions.

    PTM databases

    PhosphoSitei O35973.

    Proteomic databases

    PaxDbi O35973.
    PRIDEi O35973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021271 ; ENSMUSP00000021271 ; ENSMUSG00000020893 .
    ENSMUST00000166748 ; ENSMUSP00000132635 ; ENSMUSG00000020893 .
    GeneIDi 18626.
    KEGGi mmu:18626.
    UCSCi uc007jpg.2. mouse.

    Organism-specific databases

    CTDi 5187.
    MGIi MGI:1098283. Per1.

    Phylogenomic databases

    eggNOGi NOG253593.
    GeneTreei ENSGT00510000046467.
    HOVERGENi HBG008167.
    InParanoidi B1ASX0.
    KOi K02633.
    OMAi ELGAVHS.
    TreeFami TF318445.

    Enzyme and pathway databases

    Reactomei REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_24972. Circadian Clock.

    Miscellaneous databases

    NextBioi 294576.
    PROi O35973.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35973.
    Bgeei O35973.
    CleanExi MM_PER1.
    Genevestigatori O35973.

    Family and domain databases

    InterProi IPR001610. PAC.
    IPR000014. PAS.
    IPR022728. Period_circadian-like_C.
    [Graphical view ]
    Pfami PF12114. Period_C. 1 hit.
    [Graphical view ]
    SMARTi SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    PROSITEi PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rigui, a putative mammalian ortholog of the Drosophila period gene."
      Sun Z.S., Albrecht U., Zhuchenko O., Bailey J., Eichele G., Lee C.C.
      Cell 90:1003-1011(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Tissue: Brain.
    2. "Circadian oscillation of a mammalian homologue of the Drosophila period gene."
      Tei H., Okamura H., Shigeyoshi Y., Fukuhara C., Ozawa R., Hirose M., Sakaki Y.
      Nature 389:512-516(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Strain: BALB/c.
      Tissue: Brain.
    3. "The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription."
      Hida A., Koike N., Hirose M., Hattori M., Sakaki Y., Tei H.
      Genomics 65:224-233(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei."
      Shearman L.P., Zylka M.J., Weaver D.R., Kolakowski L.F. Jr., Reppert S.M.
      Neuron 19:1261-1269(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    6. "Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription."
      Sangoram A.M., Saez L., Antoch M.P., Gekakis N., Staknis D., Whiteley A., Fruechte E.M., Vitaterna M.H., Shimomura K., King D.P., Young M.W., Weitz C.J., Takahashi J.S.
      Neuron 21:1101-1113(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TIMELESS.
    7. "Circadian regulation of cryptochrome genes in the mouse."
      Miyamoto Y., Sancar A.
      Brain Res. Mol. Brain Res. 71:238-243(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    8. "mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop."
      Kume K., Zylka M.J., Sriram S., Shearman L.P., Weaver D.R., Jin X., Maywood E.S., Hastings M.H., Reppert S.M.
      Cell 98:193-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PER3; CRY1 AND CRY2, SUBCELLULAR LOCATION.
    9. "A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1."
      Takumi T., Nagamine Y., Miyake S., Matsubara C., Taguchi K., Takekida S., Sakakida Y., Nishikawa K., Kishimoto T., Niwa S., Okumura K., Okamura H.
      Genes Cells 4:67-75(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIMELESS, SUBCELLULAR LOCATION.
    10. "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon."
      Vielhaber E., Eide E., Rivers A., Gao Z.-H., Virshup D.M.
      Mol. Cell. Biol. 20:4888-4899(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PER2, PHOSPHORYLATION BY CKSN1E, NUCLEAR LOCALIZATION SIGNAL, SUBCELLULAR LOCATION, MUTAGENESIS OF 831-HIS--ARG-833; 835-LYS--ARG-838 AND 902-THR--THR-914.
    11. "Posttranslational mechanisms regulate the mammalian circadian clock."
      Lee C., Etchegaray J.-P., Cagampang F.R.A., Loudon A.S.I., Reppert S.M.
      Cell 107:855-867(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION, INDUCTION.
    12. Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
    13. "Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock."
      Bae K., Jin X., Maywood E.S., Hastings M.H., Reppert S.M., Weaver D.R.
      Neuron 30:525-536(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION REPRESSOR OF TRANSLATION, DISRUPTION PHENOTYPE.
    14. "The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon."
      Eide E.J., Vielhaber E.L., Hinz W.A., Virshup D.M.
      J. Biol. Chem. 277:17248-17254(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRY1 AND CRY2, SUBCELLULAR LOCATION.
    15. "Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells."
      Akashi M., Tsuchiya Y., Yoshino T., Nishida E.
      Mol. Cell. Biol. 22:1693-1703(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY CSNK1D AND CKSN1E, UBIQUITINATION.
    16. Cited for: FUNCTION.
    17. "Identification of mPer1 phosphorylation sites responsible for the nuclear entry."
      Takano A., Isojima Y., Nagai K.
      J. Biol. Chem. 279:32578-32585(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-661 AND SER-663, SUBCELLULAR LOCATION, MUTAGENESIS OF 661-SER--SER-663.
    18. "Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock."
      Lee C., Weaver D.R., Reppert S.M.
      Mol. Cell. Biol. 24:584-594(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PER2; PER3; CRY1 AND CRY2, PHOSPHORYLATION BY CSNK1E.
    19. "Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein."
      Masubuchi S., Kataoka N., Sassone-Corsi P., Okamura H.
      J. Neurosci. 25:4719-4724(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS PER2 REGULATOR, DISRUPTION PHENOTYPE.
    20. "Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance."
      Chaves I., Yagita K., Barnhoorn S., Okamura H., van der Horst G.T.J., Tamanini F.
      Mol. Cell. Biol. 26:1743-1753(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRY1 AND CRY2, SUBCELLULAR LOCATION.
    21. "Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5."
      Partch C.L., Shields K.F., Thompson C.L., Selby C.P., Sancar A.
      Proc. Natl. Acad. Sci. U.S.A. 103:10467-10472(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    22. Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION BY CSNK1D AND CSNK1E.
    23. "Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock."
      Schmutz I., Wendt S., Schnell A., Kramer A., Mansuy I.M., Albrecht U.
      PLoS ONE 6:E21325-E21325(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DEPHOSPHORYLATION.
    24. "The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1."
      Lee H.M., Chen R., Kim H., Etchegaray J.P., Weaver D.R., Lee C.
      Proc. Natl. Acad. Sci. U.S.A. 108:16451-16456(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CIRCADIAN CLOCK, PHOSPHORYLATION BY CSNK1D AND CKSN1E, SUBCELLULAR LOCATION.
    25. "Distinct roles of DBHS family members in the circadian transcriptional feedback loop."
      Kowalska E., Ripperger J.A., Muheim C., Maier B., Kurihara Y., Fox A.H., Kramer A., Brown S.A.
      Mol. Cell. Biol. 32:4585-4594(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SFPQ AND NONO.
    26. "A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention."
      Richards J., Cheng K.Y., All S., Skopis G., Jeffers L., Lynch I.J., Wingo C.S., Gumz M.L.
      Am. J. Physiol. 305:F1697-F1704(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION CRY2 REPRESSOR, INTERACTION WITH CRY2; CLOCK AND ARNTL, TISSUE SPECIFICITY.
    27. "Metabolism and the circadian clock converge."
      Eckel-Mahan K., Sassone-Corsi P.
      Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    28. "Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice."
      Noh J.Y., Han D.H., Kim M.H., Ko I.G., Kim S.E., Park N., Kyoung Choe H., Kim K.H., Kim K., Kim C.J., Cho S.
      Exp. Mol. Med. 46:E81-E81(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    29. "A Role for the circadian clock protein Per1 in the regulation of the NaCl Co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells."
      Richards J., Ko B., All S., Cheng K.Y., Hoover R.S., Gumz M.L.
      J. Biol. Chem. 289:11791-11806(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS TRANSCRIPTIONAL ACTIVATOR, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    30. "Modulation of glucocorticoid receptor induction properties by core circadian clock proteins."
      Han D.H., Lee Y.J., Kim K., Kim C.J., Cho S.
      Mol. Cell. Endocrinol. 383:170-180(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN GR REPRESSION.
    31. "Molecular architecture of the mammalian circadian clock."
      Partch C.L., Green C.B., Takahashi J.S.
      Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    32. "Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function."
      Kucera N., Schmalen I., Hennig S., Ollinger R., Strauss H.M., Grudziecki A., Wieczorek C., Kramer A., Wolf E.
      Proc. Natl. Acad. Sci. U.S.A. 109:3311-3316(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 191-502, MUTAGENESIS OF TYR-267; PHE-444 AND TRP-448, FUNCTION IN HEME BINDING, SUBUNIT.

    Entry informationi

    Entry nameiPER1_MOUSE
    AccessioniPrimary (citable) accession number: O35973
    Secondary accession number(s): B1ASX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3