ID   AL1A7_MOUSE             Reviewed;         501 AA.
AC   O35945; Q80ZX7;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Aldehyde dehydrogenase, cytosolic 1;
DE            EC=1.2.1.3;
DE   AltName: Full=ALDH class 1;
DE   AltName: Full=ALHDII;
DE   AltName: Full=ALDH-E1;
DE   AltName: Full=Aldehyde dehydrogenase family 1 member A7;
DE   AltName: Full=Aldehyde dehydrogenase phenobarbital-inducible;
GN   Name=Aldh1a7; Synonyms=Aldh-pb;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6; TISSUE=Liver;
RX   PubMed=10191271; DOI=10.1042/0264-6021:3390387;
RA   Hsu L.C., Chang W.C., Hoffmann I., Duester G.;
RT   "Molecular analysis of two closely related mouse aldehyde
RT   dehydrogenase genes: identification of a role for Aldh1, but not Aldh-
RT   pb, in the biosynthesis of retinoic acid.";
RL   Biochem. J. 339:387-395(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Can oxidize benzaldehyde, propionaldehyde and
CC       acetaldehyde (By similarity). No detectable activity with retinal.
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH.
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from
CC       ethanol: step 2/2.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Highest level in liver, high level in lung,
CC       low level in kidney and testis.
CC   -!- MISCELLANEOUS: Xenopus embryos injected with Aldh1a7 mRNA failed
CC       to produce retinoic acid in contrast to embryos injected with
CC       Aldh1a1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; U96401; AAB64411.1; -; mRNA.
DR   EMBL; BC046315; AAH46315.2; -; mRNA.
DR   IPI; IPI00336362; -.
DR   RefSeq; NP_036051.1; -.
DR   UniGene; Mm.14609; -.
DR   HSSP; P51977; 1BXS.
DR   Ensembl; ENSMUSG00000024747; Mus musculus.
DR   GeneID; 26358; -.
DR   KEGG; mmu:26358; -.
DR   NMPDR; fig|10090.3.peg.4833; -.
DR   MGI; MGI:1347050; Aldh1a7.
DR   HOGENOM; O35945; -.
DR   HOVERGEN; O35945; -.
DR   OMA; O35945; IEKANCT.
DR   BRENDA; 1.2.1.3; 244.
DR   NextBio; 304207; -.
DR   ArrayExpress; O35945; -.
DR   Bgee; O35945; -.
DR   CleanEx; MM_ALDH1A7; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0042574; P:retinal metabolic process; IDA:MGI.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NAD; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    501       Aldehyde dehydrogenase, cytosolic 1.
FT                                /FTId=PRO_0000291264.
FT   NP_BIND     246    251       NAD (By similarity).
FT   ACT_SITE    269    269       Proton acceptor (By similarity).
FT   ACT_SITE    303    303       Nucleophile (By similarity).
FT   SITE        170    170       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   501 AA;  54588 MW;  42DE97962799237B CRC64;
     MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC HVEEGDKADV
     DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATMESMN AGKVFAHAYL
     LDVEISIKAL QYFAGWADKI HGQTIPSDGN IFTYTRREPI GVCGQIIPWN GPLIIFTWKL
     GPALSCGNTV VVKPAEQTPL TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID
     KVSFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG
     QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ HNKILGLIES
     GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSMDDVIKR
     ANNTTYGLAA GVFTKDLDKA ITVSSALQAG MVWVNCYLAV PVQCPFGGFK MSGNGRELGE
     HGLYEYTELK TVAMQISQKN S
//