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O35945

- AL1A7_MOUSE

UniProt

O35945 - AL1A7_MOUSE

Protein

Aldehyde dehydrogenase, cytosolic 1

Gene

Aldh1a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Can oxidize benzaldehyde, propionaldehyde and acetaldehyde By similarity. No detectable activity with retinal.By similarity1 Publication

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei170 – 1701Transition state stabilizerBy similarity
    Active sitei269 – 2691Proton acceptorBy similarityPROSITE-ProRule annotation
    Active sitei303 – 3031NucleophileBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2516NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)
    Alternative name(s):
    ALDH class 1
    ALDH-E1
    ALHDII
    Aldehyde dehydrogenase family 1 member A7
    Aldehyde dehydrogenase phenobarbital-inducible
    Gene namesi
    Name:Aldh1a7Imported
    Synonyms:Aldh-pb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1347050. Aldh1a7.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Aldehyde dehydrogenase, cytosolic 1PRO_0000291264Add
    BLAST

    Proteomic databases

    MaxQBiO35945.
    PaxDbiO35945.
    PRIDEiO35945.

    PTM databases

    PhosphoSiteiO35945.

    Expressioni

    Tissue specificityi

    Highest level in liver, high level in lung, low level in kidney and testis.1 Publication

    Gene expression databases

    ArrayExpressiO35945.
    BgeeiO35945.
    CleanExiMM_ALDH1A7.
    GenevestigatoriO35945.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiO35945. 2 interactions.
    MINTiMINT-1869840.

    Structurei

    3D structure databases

    ProteinModelPortaliO35945.
    SMRiO35945. Positions 9-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00550000074289.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiO35945.
    KOiK07249.
    OMAiNAGKVFA.
    OrthoDBiEOG7PS1F7.
    PhylomeDBiO35945.
    TreeFamiTF300455.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC    50
    HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR 100
    LLLATMESMN AGKVFAHAYL LDVEISIKAL QYFAGWADKI HGQTIPSDGN 150
    IFTYTRREPI GVCGQIIPWN GPLIIFTWKL GPALSCGNTV VVKPAEQTPL 200
    TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID KVSFTGSTEV 250
    GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG 300
    QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ 350
    HNKILGLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE 400
    IFGPVQQIMK FKSMDDVIKR ANNTTYGLAA GVFTKDLDKA ITVSSALQAG 450
    MVWVNCYLAV PVQCPFGGFK MSGNGRELGE HGLYEYTELK TVAMQISQKN 500
    S 501
    Length:501
    Mass (Da):54,588
    Last modified:January 1, 1998 - v1
    Checksum:i42DE97962799237B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96401 mRNA. Translation: AAB64411.1.
    BC046315 mRNA. Translation: AAH46315.2.
    CCDSiCCDS29696.1.
    RefSeqiNP_036051.1. NM_011921.2.
    UniGeneiMm.14609.

    Genome annotation databases

    EnsembliENSMUST00000025656; ENSMUSP00000025656; ENSMUSG00000024747.
    GeneIDi26358.
    KEGGimmu:26358.
    UCSCiuc008gyn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96401 mRNA. Translation: AAB64411.1 .
    BC046315 mRNA. Translation: AAH46315.2 .
    CCDSi CCDS29696.1.
    RefSeqi NP_036051.1. NM_011921.2.
    UniGenei Mm.14609.

    3D structure databases

    ProteinModelPortali O35945.
    SMRi O35945. Positions 9-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O35945. 2 interactions.
    MINTi MINT-1869840.

    PTM databases

    PhosphoSitei O35945.

    Proteomic databases

    MaxQBi O35945.
    PaxDbi O35945.
    PRIDEi O35945.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025656 ; ENSMUSP00000025656 ; ENSMUSG00000024747 .
    GeneIDi 26358.
    KEGGi mmu:26358.
    UCSCi uc008gyn.1. mouse.

    Organism-specific databases

    CTDi 26358.
    MGIi MGI:1347050. Aldh1a7.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00550000074289.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi O35945.
    KOi K07249.
    OMAi NAGKVFA.
    OrthoDBi EOG7PS1F7.
    PhylomeDBi O35945.
    TreeFami TF300455.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Miscellaneous databases

    ChiTaRSi Aldh1a7. mouse.
    NextBioi 304207.
    PROi O35945.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35945.
    Bgeei O35945.
    CleanExi MM_ALDH1A7.
    Genevestigatori O35945.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid."
      Hsu L.C., Chang W.C., Hoffmann I., Duester G.
      Biochem. J. 339:387-395(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Olfactory epitheliumImported.

    Entry informationi

    Entry nameiAL1A7_MOUSE
    AccessioniPrimary (citable) accession number: O35945
    Secondary accession number(s): Q80ZX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Xenopus embryos injected with Aldh1a7 mRNA failed to produce retinoic acid in contrast to embryos injected with Aldh1a1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3