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Protein

Aldehyde dehydrogenase, cytosolic 1

Gene

Aldh1a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal.By similarity1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase family 3 member B2 (Aldh3b2), Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei170Transition state stabilizerBy similarity1
Active sitei269Proton acceptorPROSITE-ProRule annotationBy similarity1
Active sitei303NucleophilePROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 251NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.3. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.
R-MMU-70350. Fructose catabolism.
R-MMU-71384. Ethanol oxidation.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)
Alternative name(s):
ALDH class 1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A7
Aldehyde dehydrogenase phenobarbital-inducible
Gene namesi
Name:Aldh1a7Imported
Synonyms:Aldh-pb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1347050. Aldh1a7.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002912642 – 501Aldehyde dehydrogenase, cytosolic 1Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei367N6-acetyllysineBy similarity1
Modified residuei410N6-acetyllysineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei419N6-acetyllysineBy similarity1
Modified residuei435N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO35945.
PaxDbiO35945.
PRIDEiO35945.

PTM databases

iPTMnetiO35945.
PhosphoSitePlusiO35945.
SwissPalmiO35945.

Expressioni

Tissue specificityi

Highest level in liver, high level in lung, low level in kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000024747.
CleanExiMM_ALDH1A7.
ExpressionAtlasiO35945. baseline and differential.
GenevisibleiO35945. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiO35945. 2 interactors.
MINTiMINT-1869840.
STRINGi10090.ENSMUSP00000025656.

Structurei

3D structure databases

ProteinModelPortaliO35945.
SMRiO35945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiO35945.
KOiK07249.
OMAiRCFVEAS.
OrthoDBiEOG091G05E8.
PhylomeDBiO35945.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC
60 70 80 90 100
HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR
110 120 130 140 150
LLLATMESMN AGKVFAHAYL LDVEISIKAL QYFAGWADKI HGQTIPSDGN
160 170 180 190 200
IFTYTRREPI GVCGQIIPWN GPLIIFTWKL GPALSCGNTV VVKPAEQTPL
210 220 230 240 250
TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID KVSFTGSTEV
260 270 280 290 300
GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG
310 320 330 340 350
QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ
360 370 380 390 400
HNKILGLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSMDDVIKR ANNTTYGLAA GVFTKDLDKA ITVSSALQAG
460 470 480 490 500
MVWVNCYLAV PVQCPFGGFK MSGNGRELGE HGLYEYTELK TVAMQISQKN

S
Length:501
Mass (Da):54,588
Last modified:January 1, 1998 - v1
Checksum:i42DE97962799237B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96401 mRNA. Translation: AAB64411.1.
BC046315 mRNA. Translation: AAH46315.2.
CCDSiCCDS29696.1.
RefSeqiNP_036051.1. NM_011921.2.
UniGeneiMm.14609.

Genome annotation databases

EnsembliENSMUST00000025656; ENSMUSP00000025656; ENSMUSG00000024747.
GeneIDi26358.
KEGGimmu:26358.
UCSCiuc008gyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96401 mRNA. Translation: AAB64411.1.
BC046315 mRNA. Translation: AAH46315.2.
CCDSiCCDS29696.1.
RefSeqiNP_036051.1. NM_011921.2.
UniGeneiMm.14609.

3D structure databases

ProteinModelPortaliO35945.
SMRiO35945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35945. 2 interactors.
MINTiMINT-1869840.
STRINGi10090.ENSMUSP00000025656.

PTM databases

iPTMnetiO35945.
PhosphoSitePlusiO35945.
SwissPalmiO35945.

Proteomic databases

MaxQBiO35945.
PaxDbiO35945.
PRIDEiO35945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025656; ENSMUSP00000025656; ENSMUSG00000024747.
GeneIDi26358.
KEGGimmu:26358.
UCSCiuc008gyn.1. mouse.

Organism-specific databases

CTDi26358.
MGIiMGI:1347050. Aldh1a7.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiO35945.
KOiK07249.
OMAiRCFVEAS.
OrthoDBiEOG091G05E8.
PhylomeDBiO35945.
TreeFamiTF300455.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BRENDAi1.2.1.3. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.
R-MMU-70350. Fructose catabolism.
R-MMU-71384. Ethanol oxidation.

Miscellaneous databases

ChiTaRSiAldh1a7. mouse.
PROiO35945.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024747.
CleanExiMM_ALDH1A7.
ExpressionAtlasiO35945. baseline and differential.
GenevisibleiO35945. MM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1A7_MOUSE
AccessioniPrimary (citable) accession number: O35945
Secondary accession number(s): Q80ZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Xenopus embryos injected with Aldh1a7 mRNA failed to produce retinoic acid in contrast to embryos injected with Aldh1a1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.