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O35945

- AL1A7_MOUSE

UniProt

O35945 - AL1A7_MOUSE

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Protein
Aldehyde dehydrogenase, cytosolic 1
Gene
Aldh1a7, Aldh-pb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Can oxidize benzaldehyde, propionaldehyde and acetaldehyde By similarity. No detectable activity with retinal.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei170 – 1701Transition state stabilizer By similarityBy similarity
Active sitei269 – 2691Proton acceptor By similarityBy similarity
Active sitei303 – 3031Nucleophile By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2516NAD By similarityBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)
Alternative name(s):
ALDH class 1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A7
Aldehyde dehydrogenase phenobarbital-inducible
Gene namesi
Name:Aldh1a7
Synonyms:Aldh-pb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1347050. Aldh1a7.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Aldehyde dehydrogenase, cytosolic 1
PRO_0000291264Add
BLAST

Proteomic databases

MaxQBiO35945.
PaxDbiO35945.
PRIDEiO35945.

PTM databases

PhosphoSiteiO35945.

Expressioni

Tissue specificityi

Highest level in liver, high level in lung, low level in kidney and testis.1 Publication

Gene expression databases

ArrayExpressiO35945.
BgeeiO35945.
CleanExiMM_ALDH1A7.
GenevestigatoriO35945.

Interactioni

Subunit structurei

Homotetramer By similarity.By similarity

Protein-protein interaction databases

IntActiO35945. 2 interactions.
MINTiMINT-1869840.

Structurei

3D structure databases

ProteinModelPortaliO35945.
SMRiO35945. Positions 9-501.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00550000074289.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiO35945.
KOiK07249.
OMAiNAGKVFA.
OrthoDBiEOG7PS1F7.
PhylomeDBiO35945.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35945-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC    50
HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR 100
LLLATMESMN AGKVFAHAYL LDVEISIKAL QYFAGWADKI HGQTIPSDGN 150
IFTYTRREPI GVCGQIIPWN GPLIIFTWKL GPALSCGNTV VVKPAEQTPL 200
TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID KVSFTGSTEV 250
GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG 300
QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ 350
HNKILGLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE 400
IFGPVQQIMK FKSMDDVIKR ANNTTYGLAA GVFTKDLDKA ITVSSALQAG 450
MVWVNCYLAV PVQCPFGGFK MSGNGRELGE HGLYEYTELK TVAMQISQKN 500
S 501
Length:501
Mass (Da):54,588
Last modified:January 1, 1998 - v1
Checksum:i42DE97962799237B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96401 mRNA. Translation: AAB64411.1.
BC046315 mRNA. Translation: AAH46315.2.
CCDSiCCDS29696.1.
RefSeqiNP_036051.1. NM_011921.2.
UniGeneiMm.14609.

Genome annotation databases

EnsembliENSMUST00000025656; ENSMUSP00000025656; ENSMUSG00000024747.
GeneIDi26358.
KEGGimmu:26358.
UCSCiuc008gyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96401 mRNA. Translation: AAB64411.1 .
BC046315 mRNA. Translation: AAH46315.2 .
CCDSi CCDS29696.1.
RefSeqi NP_036051.1. NM_011921.2.
UniGenei Mm.14609.

3D structure databases

ProteinModelPortali O35945.
SMRi O35945. Positions 9-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O35945. 2 interactions.
MINTi MINT-1869840.

PTM databases

PhosphoSitei O35945.

Proteomic databases

MaxQBi O35945.
PaxDbi O35945.
PRIDEi O35945.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025656 ; ENSMUSP00000025656 ; ENSMUSG00000024747 .
GeneIDi 26358.
KEGGi mmu:26358.
UCSCi uc008gyn.1. mouse.

Organism-specific databases

CTDi 26358.
MGIi MGI:1347050. Aldh1a7.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00550000074289.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi O35945.
KOi K07249.
OMAi NAGKVFA.
OrthoDBi EOG7PS1F7.
PhylomeDBi O35945.
TreeFami TF300455.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Miscellaneous databases

ChiTaRSi Aldh1a7. mouse.
NextBioi 304207.
PROi O35945.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35945.
Bgeei O35945.
CleanExi MM_ALDH1A7.
Genevestigatori O35945.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid."
    Hsu L.C., Chang W.C., Hoffmann I., Duester G.
    Biochem. J. 339:387-395(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiAL1A7_MOUSE
AccessioniPrimary (citable) accession number: O35945
Secondary accession number(s): Q80ZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Xenopus embryos injected with Aldh1a7 mRNA failed to produce retinoic acid in contrast to embryos injected with Aldh1a1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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