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O35945 (AL1A7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase, cytosolic 1

EC=1.2.1.3
Alternative name(s):
ALDH class 1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A7
Aldehyde dehydrogenase phenobarbital-inducible
Gene names
Name:Aldh1a7
Synonyms:Aldh-pb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Can oxidize benzaldehyde, propionaldehyde and acetaldehyde By similarity. No detectable activity with retinal. Ref.1

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Subunit structure

Homotetramer By similarity. UniProtKB P13601

Subcellular location

Cytoplasm By similarity UniProtKB P13601.

Tissue specificity

Highest level in liver, high level in lung, low level in kidney and testis. Ref.1

Miscellaneous

Xenopus embryos injected with Aldh1a7 mRNA failed to produce retinoic acid in contrast to embryos injected with Aldh1a1.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Aldehyde dehydrogenase, cytosolic 1
PRO_0000291264

Regions

Nucleotide binding246 – 2516NAD By similarity UniProtKB Q28399

Sites

Active site2691Proton acceptor By similarity UniProtKB P51977
Active site3031Nucleophile By similarity UniProtKB P51977
Site1701Transition state stabilizer By similarity UniProtKB P51977

Sequences

Sequence LengthMass (Da)Tools
O35945 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 42DE97962799237B

FASTA50154,588
        10         20         30         40         50         60 
MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC HVEEGDKADV 

        70         80         90        100        110        120 
DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATMESMN AGKVFAHAYL 

       130        140        150        160        170        180 
LDVEISIKAL QYFAGWADKI HGQTIPSDGN IFTYTRREPI GVCGQIIPWN GPLIIFTWKL 

       190        200        210        220        230        240 
GPALSCGNTV VVKPAEQTPL TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID 

       250        260        270        280        290        300 
KVSFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG 

       310        320        330        340        350        360 
QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ HNKILGLIES 

       370        380        390        400        410        420 
GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSMDDVIKR 

       430        440        450        460        470        480 
ANNTTYGLAA GVFTKDLDKA ITVSSALQAG MVWVNCYLAV PVQCPFGGFK MSGNGRELGE 

       490        500 
HGLYEYTELK TVAMQISQKN S 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid."
Hsu L.C., Chang W.C., Hoffmann I., Duester G.
Biochem. J. 339:387-395(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U96401 mRNA. Translation: AAB64411.1.
BC046315 mRNA. Translation: AAH46315.2.
RefSeqNP_036051.1. NM_011921.2.
UniGeneMm.14609.

3D structure databases

ProteinModelPortalO35945.
SMRO35945. Positions 9-501.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO35945. 2 interactions.
MINTMINT-1869840.

PTM databases

PhosphoSiteO35945.

Proteomic databases

PaxDbO35945.
PRIDEO35945.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025656; ENSMUSP00000025656; ENSMUSG00000024747.
GeneID26358.
KEGGmmu:26358.
UCSCuc008gyn.1. mouse.

Organism-specific databases

CTD26358.
MGIMGI:1347050. Aldh1a7.

Phylogenomic databases

eggNOGCOG1012.
GeneTreeENSGT00550000074289.
HOGENOMHOG000271505.
HOVERGENHBG000097.
InParanoidO35945.
KOK07249.
OMASEESTLM.
OrthoDBEOG7PS1F7.
PhylomeDBO35945.
TreeFamTF300455.

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Gene expression databases

ArrayExpressO35945.
BgeeO35945.
CleanExMM_ALDH1A7.
GenevestigatorO35945.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAldh1a7. mouse.
NextBio304207.
PROO35945.
SOURCESearch...

Entry information

Entry nameAL1A7_MOUSE
AccessionPrimary (citable) accession number: O35945
Secondary accession number(s): Q80ZX7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot