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Protein

Aldehyde dehydrogenase, cytosolic 1

Gene

Aldh1a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal.By similarity1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei170 – 1701Transition state stabilizerBy similarity
Active sitei269 – 2691Proton acceptorBy similarityPROSITE-ProRule annotation
Active sitei303 – 3031NucleophileBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2516NADBy similarity

GO - Molecular functioni

  1. 3-chloroallyl aldehyde dehydrogenase activity Source: GO_Central
  2. benzaldehyde dehydrogenase (NAD+) activity Source: GO_Central
  3. retinal dehydrogenase activity Source: GO_Central

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_260489. Ethanol oxidation.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)
Alternative name(s):
ALDH class 1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A7
Aldehyde dehydrogenase phenobarbital-inducible
Gene namesi
Name:Aldh1a7Imported
Synonyms:Aldh-pb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1347050. Aldh1a7.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Aldehyde dehydrogenase, cytosolic 1PRO_0000291264Add
BLAST

Proteomic databases

MaxQBiO35945.
PaxDbiO35945.
PRIDEiO35945.

PTM databases

PhosphoSiteiO35945.

Expressioni

Tissue specificityi

Highest level in liver, high level in lung, low level in kidney and testis.1 Publication

Gene expression databases

BgeeiO35945.
CleanExiMM_ALDH1A7.
ExpressionAtlasiO35945. baseline and differential.
GenevestigatoriO35945.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiO35945. 2 interactions.
MINTiMINT-1869840.

Structurei

3D structure databases

ProteinModelPortaliO35945.
SMRiO35945. Positions 9-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiO35945.
KOiK07249.
OMAiWINTYNN.
OrthoDBiEOG7PS1F7.
PhylomeDBiO35945.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35945-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSSKKFPV LNPATEEVIC
60 70 80 90 100
HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR
110 120 130 140 150
LLLATMESMN AGKVFAHAYL LDVEISIKAL QYFAGWADKI HGQTIPSDGN
160 170 180 190 200
IFTYTRREPI GVCGQIIPWN GPLIIFTWKL GPALSCGNTV VVKPAEQTPL
210 220 230 240 250
TALHMASLIK EAGFPPGVVN IVPGYGPTAG GAISSHMDID KVSFTGSTEV
260 270 280 290 300
GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG
310 320 330 340 350
QICVAASRLF VEESIYDEFV RRSVERAKKY ILGNPLNSGI NQGPQIDKEQ
360 370 380 390 400
HNKILGLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSMDDVIKR ANNTTYGLAA GVFTKDLDKA ITVSSALQAG
460 470 480 490 500
MVWVNCYLAV PVQCPFGGFK MSGNGRELGE HGLYEYTELK TVAMQISQKN

S
Length:501
Mass (Da):54,588
Last modified:January 1, 1998 - v1
Checksum:i42DE97962799237B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96401 mRNA. Translation: AAB64411.1.
BC046315 mRNA. Translation: AAH46315.2.
CCDSiCCDS29696.1.
RefSeqiNP_036051.1. NM_011921.2.
UniGeneiMm.14609.

Genome annotation databases

EnsembliENSMUST00000025656; ENSMUSP00000025656; ENSMUSG00000024747.
GeneIDi26358.
KEGGimmu:26358.
UCSCiuc008gyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96401 mRNA. Translation: AAB64411.1.
BC046315 mRNA. Translation: AAH46315.2.
CCDSiCCDS29696.1.
RefSeqiNP_036051.1. NM_011921.2.
UniGeneiMm.14609.

3D structure databases

ProteinModelPortaliO35945.
SMRiO35945. Positions 9-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35945. 2 interactions.
MINTiMINT-1869840.

PTM databases

PhosphoSiteiO35945.

Proteomic databases

MaxQBiO35945.
PaxDbiO35945.
PRIDEiO35945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025656; ENSMUSP00000025656; ENSMUSG00000024747.
GeneIDi26358.
KEGGimmu:26358.
UCSCiuc008gyn.1. mouse.

Organism-specific databases

CTDi26358.
MGIiMGI:1347050. Aldh1a7.

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiO35945.
KOiK07249.
OMAiWINTYNN.
OrthoDBiEOG7PS1F7.
PhylomeDBiO35945.
TreeFamiTF300455.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
ReactomeiREACT_260489. Ethanol oxidation.

Miscellaneous databases

ChiTaRSiAldh1a7. mouse.
NextBioi304207.
PROiO35945.
SOURCEiSearch...

Gene expression databases

BgeeiO35945.
CleanExiMM_ALDH1A7.
ExpressionAtlasiO35945. baseline and differential.
GenevestigatoriO35945.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid."
    Hsu L.C., Chang W.C., Hoffmann I., Duester G.
    Biochem. J. 339:387-395(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Olfactory epitheliumImported.

Entry informationi

Entry nameiAL1A7_MOUSE
AccessioniPrimary (citable) accession number: O35945
Secondary accession number(s): Q80ZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Xenopus embryos injected with Aldh1a7 mRNA failed to produce retinoic acid in contrast to embryos injected with Aldh1a1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.