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O35932 (PD2RL_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin D2 receptor-like

Short name=PGD receptor-like
Short name=PGD2 receptor-like
Alternative name(s):
Prostanoid DP receptor-like
Gene names
Name:Ptgdrl
Synonyms:Ptgdr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Tissue specificity

Strongly expressed in eye and gastrointestinal tract (GIT), moderately in the brain and oviduct and weakly in the epididymis. In the eye, expressed in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina. In the brain, expressed in leptomeninges, choroid plexus and spinal cord (sensory and motor neurons of the dorsal and ventral horns). In the stomach, expressed in the mucous-secreting goblet cells and the columnar epithelium. Expressed in platelets. Ref.1 Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Prostaglandin D2 receptor-like
PRO_0000370712

Regions

Topological domain1 – 2020Extracellular Potential
Transmembrane21 – 4121Helical; Name=1; Potential
Topological domain42 – 5716Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 10628Extracellular Potential
Transmembrane107 – 12721Helical; Name=3; Potential
Topological domain128 – 14922Cytoplasmic Potential
Transmembrane150 – 17021Helical; Name=4; Potential
Topological domain171 – 19424Extracellular Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Topological domain216 – 26146Cytoplasmic Potential
Transmembrane262 – 28221Helical; Name=6; Potential
Topological domain283 – 30624Extracellular Potential
Transmembrane307 – 32721Helical; Name=7; Potential
Topological domain328 – 35730Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 182 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35932 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: DB966276DD68184C

FASTA35739,803
        10         20         30         40         50         60 
MNESYRCQAA TWVERGSSAT MGGVLFSAGL LGNLLALVLL ARSGLGSCRP GPLHPPPSVF 

        70         80         90        100        110        120 
YVLVCGLTVT HLLGKCLISP MVLAAYAQNR SLKELLPASG NQLCEAFAFL MSFFGLASTL 

       130        140        150        160        170        180 
QLLAMALECW LSLGHPFFYQ RHITARRGVL VAPVAGAFSL AFCALPFAGF GKFVQYCPGT 

       190        200        210        220        230        240 
WCFIQMIHKK RSFSVIGFSV LYSSLMALLV LATVVCNLGA MSNLYAMHRR QRHHPRRCSR 

       250        260        270        280        290        300 
DRAQSGSDYR HGSPNPLEEL DHFVLLALTT VLFTMCSLPL IYRAYYGAFK LVDRADGDSE 

       310        320        330        340        350 
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKAFTRPLI YRNWCSHSWQ TNMESTL 

« Hide

References

[1]"Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes."
Gerashchenko D., Beuckmann C.T., Kanaoka Y., Eguchi N., Gordon W.C., Urade Y., Bazan N.G., Hayaishi O.
J. Neurochem. 71:937-945(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Retina.
[2]"Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
Town M.H., Casals-Stenzel J., Schillinger E.
Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U92289 mRNA. Translation: AAB71762.1.
RefSeqNP_071577.1. NM_022241.1.
UniGeneRn.110861.

3D structure databases

ProteinModelPortalO35932.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000048101.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEO35932.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID63889.
KEGGrno:63889.

Organism-specific databases

CTD63889.
RGD619707. Ptgdrl.

Phylogenomic databases

eggNOGNOG248831.
HOGENOMHOG000115475.
InParanoidO35932.
KOK04332.
PhylomeDBO35932.

Gene expression databases

GenevestigatorO35932.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF9. PTHR11866:SF9. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612534.

Entry information

Entry namePD2RL_RAT
AccessionPrimary (citable) accession number: O35932
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries