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Protein

Prostaglandin D2 receptor-like

Gene

Ptgdrl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

  • prostacyclin receptor activity Source: GO_Central
  • prostaglandin D receptor activity Source: RGD
  • prostaglandin receptor activity Source: RGD

GO - Biological processi

  • cellular response to prostaglandin D stimulus Source: GO_Central
  • inflammatory response Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • positive regulation of penile erection Source: RGD
  • positive regulation of vasodilation Source: RGD
  • regulation of cytosolic calcium ion concentration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor-like
Short name:
PGD receptor-like
Short name:
PGD2 receptor-like
Alternative name(s):
Prostanoid DP receptor-like
Gene namesi
Name:Ptgdrl
Synonyms:Ptgdr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619707. Ptgdrl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 106ExtracellularSequence analysisAdd BLAST28
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 149CytoplasmicSequence analysisAdd BLAST22
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 194ExtracellularSequence analysisAdd BLAST24
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 261CytoplasmicSequence analysisAdd BLAST46
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 306ExtracellularSequence analysisAdd BLAST24
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 357CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003707121 – 357Prostaglandin D2 receptor-likeAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35932.

Expressioni

Tissue specificityi

Strongly expressed in eye and gastrointestinal tract (GIT), moderately in the brain and oviduct and weakly in the epididymis. In the eye, expressed in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina. In the brain, expressed in leptomeninges, choroid plexus and spinal cord (sensory and motor neurons of the dorsal and ventral horns). In the stomach, expressed in the mucous-secreting goblet cells and the columnar epithelium. Expressed in platelets.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048101.

Structurei

3D structure databases

ProteinModelPortaliO35932.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000115475.
InParanoidiO35932.
KOiK04332.
PhylomeDBiO35932.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESYRCQAA TWVERGSSAT MGGVLFSAGL LGNLLALVLL ARSGLGSCRP
60 70 80 90 100
GPLHPPPSVF YVLVCGLTVT HLLGKCLISP MVLAAYAQNR SLKELLPASG
110 120 130 140 150
NQLCEAFAFL MSFFGLASTL QLLAMALECW LSLGHPFFYQ RHITARRGVL
160 170 180 190 200
VAPVAGAFSL AFCALPFAGF GKFVQYCPGT WCFIQMIHKK RSFSVIGFSV
210 220 230 240 250
LYSSLMALLV LATVVCNLGA MSNLYAMHRR QRHHPRRCSR DRAQSGSDYR
260 270 280 290 300
HGSPNPLEEL DHFVLLALTT VLFTMCSLPL IYRAYYGAFK LVDRADGDSE
310 320 330 340 350
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKAFTRPLI YRNWCSHSWQ

TNMESTL
Length:357
Mass (Da):39,803
Last modified:January 1, 1998 - v1
Checksum:iDB966276DD68184C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92289 mRNA. Translation: AAB71762.1.
RefSeqiNP_071577.1. NM_022241.1.
UniGeneiRn.110861.
Rn.57393.

Genome annotation databases

GeneIDi63889.
KEGGirno:63889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92289 mRNA. Translation: AAB71762.1.
RefSeqiNP_071577.1. NM_022241.1.
UniGeneiRn.110861.
Rn.57393.

3D structure databases

ProteinModelPortaliO35932.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048101.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO35932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi63889.
KEGGirno:63889.

Organism-specific databases

CTDi63889.
RGDi619707. Ptgdrl.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000115475.
InParanoidiO35932.
KOiK04332.
PhylomeDBiO35932.

Miscellaneous databases

PROiO35932.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPD2RL_RAT
AccessioniPrimary (citable) accession number: O35932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.