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O35932

- PD2RL_RAT

UniProt

O35932 - PD2RL_RAT

Protein

Prostaglandin D2 receptor-like

Gene

Ptgdrl

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.By similarity

    GO - Molecular functioni

    1. prostaglandin D receptor activity Source: RGD
    2. prostaglandin receptor activity Source: RGD

    GO - Biological processi

    1. cytosolic calcium ion homeostasis Source: RGD
    2. positive regulation of penile erection Source: RGD
    3. positive regulation of vasodilation Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin D2 receptor-like
    Short name:
    PGD receptor-like
    Short name:
    PGD2 receptor-like
    Alternative name(s):
    Prostanoid DP receptor-like
    Gene namesi
    Name:Ptgdrl
    Synonyms:Ptgdr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619707. Ptgdrl.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: RGD
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Prostaglandin D2 receptor-likePRO_0000370712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO35932.

    Expressioni

    Tissue specificityi

    Strongly expressed in eye and gastrointestinal tract (GIT), moderately in the brain and oviduct and weakly in the epididymis. In the eye, expressed in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina. In the brain, expressed in leptomeninges, choroid plexus and spinal cord (sensory and motor neurons of the dorsal and ventral horns). In the stomach, expressed in the mucous-secreting goblet cells and the columnar epithelium. Expressed in platelets.2 Publications

    Gene expression databases

    GenevestigatoriO35932.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000048101.

    Structurei

    3D structure databases

    ProteinModelPortaliO35932.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini42 – 5716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 10628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 26146CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 30624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 35730CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG248831.
    HOGENOMiHOG000115475.
    InParanoidiO35932.
    KOiK04332.
    PhylomeDBiO35932.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000376. Pglndn_D_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01788. PROSTANOIDR.
    PR00854. PRSTNOIDDPR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35932-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNESYRCQAA TWVERGSSAT MGGVLFSAGL LGNLLALVLL ARSGLGSCRP    50
    GPLHPPPSVF YVLVCGLTVT HLLGKCLISP MVLAAYAQNR SLKELLPASG 100
    NQLCEAFAFL MSFFGLASTL QLLAMALECW LSLGHPFFYQ RHITARRGVL 150
    VAPVAGAFSL AFCALPFAGF GKFVQYCPGT WCFIQMIHKK RSFSVIGFSV 200
    LYSSLMALLV LATVVCNLGA MSNLYAMHRR QRHHPRRCSR DRAQSGSDYR 250
    HGSPNPLEEL DHFVLLALTT VLFTMCSLPL IYRAYYGAFK LVDRADGDSE 300
    DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKAFTRPLI YRNWCSHSWQ 350
    TNMESTL 357
    Length:357
    Mass (Da):39,803
    Last modified:January 1, 1998 - v1
    Checksum:iDB966276DD68184C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92289 mRNA. Translation: AAB71762.1.
    RefSeqiNP_071577.1. NM_022241.1.
    UniGeneiRn.110861.

    Genome annotation databases

    GeneIDi63889.
    KEGGirno:63889.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92289 mRNA. Translation: AAB71762.1 .
    RefSeqi NP_071577.1. NM_022241.1.
    UniGenei Rn.110861.

    3D structure databases

    ProteinModelPortali O35932.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000048101.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi O35932.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 63889.
    KEGGi rno:63889.

    Organism-specific databases

    CTDi 63889.
    RGDi 619707. Ptgdrl.

    Phylogenomic databases

    eggNOGi NOG248831.
    HOGENOMi HOG000115475.
    InParanoidi O35932.
    KOi K04332.
    PhylomeDBi O35932.

    Miscellaneous databases

    NextBioi 612534.

    Gene expression databases

    Genevestigatori O35932.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000376. Pglndn_D_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01788. PROSTANOIDR.
    PR00854. PRSTNOIDDPR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes."
      Gerashchenko D., Beuckmann C.T., Kanaoka Y., Eguchi N., Gordon W.C., Urade Y., Bazan N.G., Hayaishi O.
      J. Neurochem. 71:937-945(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Retina.
    2. "Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
      Town M.H., Casals-Stenzel J., Schillinger E.
      Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPD2RL_RAT
    AccessioniPrimary (citable) accession number: O35932
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3