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O35932

- PD2RL_RAT

UniProt

O35932 - PD2RL_RAT

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Protein

Prostaglandin D2 receptor-like

Gene
Ptgdrl, Ptgdr2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.

GO - Molecular functioni

  1. prostaglandin D receptor activity Source: RGD
  2. prostaglandin receptor activity Source: RGD

GO - Biological processi

  1. cytosolic calcium ion homeostasis Source: RGD
  2. positive regulation of penile erection Source: RGD
  3. positive regulation of vasodilation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor-like
Short name:
PGD receptor-like
Short name:
PGD2 receptor-like
Alternative name(s):
Prostanoid DP receptor-like
Gene namesi
Name:Ptgdrl
Synonyms:Ptgdr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619707. Ptgdrl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Extracellular Reviewed predictionAdd
BLAST
Transmembranei21 – 4121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini42 – 5716Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei58 – 7821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 10628Extracellular Reviewed predictionAdd
BLAST
Transmembranei107 – 12721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini128 – 14922Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei150 – 17021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini171 – 19424Extracellular Reviewed predictionAdd
BLAST
Transmembranei195 – 21521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini216 – 26146Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei262 – 28221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini283 – 30624Extracellular Reviewed predictionAdd
BLAST
Transmembranei307 – 32721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini328 – 35730Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: RGD
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Prostaglandin D2 receptor-likePRO_0000370712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) Reviewed prediction
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi104 ↔ 182 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO35932.

Expressioni

Tissue specificityi

Strongly expressed in eye and gastrointestinal tract (GIT), moderately in the brain and oviduct and weakly in the epididymis. In the eye, expressed in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina. In the brain, expressed in leptomeninges, choroid plexus and spinal cord (sensory and motor neurons of the dorsal and ventral horns). In the stomach, expressed in the mucous-secreting goblet cells and the columnar epithelium. Expressed in platelets.2 Publications

Gene expression databases

GenevestigatoriO35932.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048101.

Structurei

3D structure databases

ProteinModelPortaliO35932.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248831.
HOGENOMiHOG000115475.
InParanoidiO35932.
KOiK04332.
PhylomeDBiO35932.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35932-1 [UniParc]FASTAAdd to Basket

« Hide

MNESYRCQAA TWVERGSSAT MGGVLFSAGL LGNLLALVLL ARSGLGSCRP    50
GPLHPPPSVF YVLVCGLTVT HLLGKCLISP MVLAAYAQNR SLKELLPASG 100
NQLCEAFAFL MSFFGLASTL QLLAMALECW LSLGHPFFYQ RHITARRGVL 150
VAPVAGAFSL AFCALPFAGF GKFVQYCPGT WCFIQMIHKK RSFSVIGFSV 200
LYSSLMALLV LATVVCNLGA MSNLYAMHRR QRHHPRRCSR DRAQSGSDYR 250
HGSPNPLEEL DHFVLLALTT VLFTMCSLPL IYRAYYGAFK LVDRADGDSE 300
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKAFTRPLI YRNWCSHSWQ 350
TNMESTL 357
Length:357
Mass (Da):39,803
Last modified:January 1, 1998 - v1
Checksum:iDB966276DD68184C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92289 mRNA. Translation: AAB71762.1.
RefSeqiNP_071577.1. NM_022241.1.
UniGeneiRn.110861.

Genome annotation databases

GeneIDi63889.
KEGGirno:63889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92289 mRNA. Translation: AAB71762.1 .
RefSeqi NP_071577.1. NM_022241.1.
UniGenei Rn.110861.

3D structure databases

ProteinModelPortali O35932.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000048101.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi O35932.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 63889.
KEGGi rno:63889.

Organism-specific databases

CTDi 63889.
RGDi 619707. Ptgdrl.

Phylogenomic databases

eggNOGi NOG248831.
HOGENOMi HOG000115475.
InParanoidi O35932.
KOi K04332.
PhylomeDBi O35932.

Miscellaneous databases

NextBioi 612534.

Gene expression databases

Genevestigatori O35932.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes."
    Gerashchenko D., Beuckmann C.T., Kanaoka Y., Eguchi N., Gordon W.C., Urade Y., Bazan N.G., Hayaishi O.
    J. Neurochem. 71:937-945(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Retina.
  2. "Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
    Town M.H., Casals-Stenzel J., Schillinger E.
    Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPD2RL_RAT
AccessioniPrimary (citable) accession number: O35932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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