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Protein

GTP-binding protein REM 1

Gene

Rem1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes endothelial cell sprouting and actin cytoskeletal reorganization (By similarity). May be involved in angiogenesis. May function in Ca2+ signaling.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94GTPBy similarity8
Nucleotide bindingi194 – 197GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 1
Alternative name(s):
Rad and Gem-like GTP-binding protein 1
Gene namesi
Name:Rem1
Synonyms:Rem
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1097696. Rem1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224821 – 297GTP-binding protein REM 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35929.
PaxDbiO35929.
PRIDEiO35929.

PTM databases

iPTMnetiO35929.
PhosphoSitePlusiO35929.

Expressioni

Tissue specificityi

High expression in cardiac muscle. Moderate expression in lung, skeletal muscle and kidney. Low levels in spleen and brain.

Inductioni

Repressed by lipopolysaccharide stimulation.

Gene expression databases

BgeeiENSMUSG00000000359.
CleanExiMM_REM1.
ExpressionAtlasiO35929. baseline and differential.
GenevisibleiO35929. MM.

Interactioni

Subunit structurei

In vitro, interacts with calmodulin in a calcium-dependent manner (By similarity). Interacts 14-3-3 family members including YWHAE, YWHAH, YWHAQ, YWHAZ in a phosphorylation-dependent manner.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
YwhazP631012EBI-7068866,EBI-354751

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35929. 1 interactor.
MINTiMINT-101892.
STRINGi10090.ENSMUSP00000000369.

Structurei

3D structure databases

ProteinModelPortaliO35929.
SMRiO35929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni267 – 286Calmodulin-bindingAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 287Arg-richAdd BLAST48

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiO35929.
KOiK07847.
OMAiKVRSKSC.
OrthoDBiEOG091G0OCN.
PhylomeDBiO35929.
TreeFamiTF314379.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR017358. RGK.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PIRSFiPIRSF038017. GTP-binding_GEM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51421. RAS. 1 hit.

Sequencei

Sequence statusi: Complete.

O35929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNTQQEAK TTLRRRASTP LPLSSRGHQP GRLCTAPSAP SQHPRLGQSV
60 70 80 90 100
SLNPPVRKPS PAQDGWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF
110 120 130 140 150
AEKQDRDPHE QLGGVYERTL SVDGEDTTLV VMDTWEAEKL DESWCQESCL
160 170 180 190 200
QAGSAYVIVY SIADRSSFES ASELRIQLRR THQANHVPII LVGNKADLAR
210 220 230 240 250
CREVSVEEGR ACAVVFDCKF IETSATLQHN VTELFEGVVR QLRLRRQDNA
260 270 280 290
APETPSPRRR ASLGQRARRF LARLTARSAR RRALKARSKS CHNLAVL
Length:297
Mass (Da):32,909
Last modified:January 1, 1998 - v1
Checksum:i4DCFFC50132C8262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91601 mRNA. Translation: AAB71639.1.
AK053133 mRNA. Translation: BAC35274.1.
AK084460 mRNA. Translation: BAC39190.1.
CCDSiCCDS16895.1.
RefSeqiNP_033073.1. NM_009047.5.
UniGeneiMm.8752.

Genome annotation databases

EnsembliENSMUST00000000369; ENSMUSP00000000369; ENSMUSG00000000359.
GeneIDi19700.
KEGGimmu:19700.
UCSCiuc008nfw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiREM1_MOUSE
AccessioniPrimary (citable) accession number: O35929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: January 1, 1998
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families