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O35927

- CTND2_MOUSE

UniProt

O35927 - CTND2_MOUSE

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Protein

Catenin delta-2

Gene

Ctnnd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33.2 Publications

GO - Biological processi

  1. learning Source: MGI
  2. morphogenesis of a branching structure Source: MGI
  3. multicellular organismal development Source: UniProtKB-KW
  4. regulation of synaptic plasticity Source: MGI
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. single organismal cell-cell adhesion Source: InterPro
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin delta-2
Alternative name(s):
Neural plakophilin-related ARM-repeat protein
Short name:
NPRAP
Neurojungin
Gene namesi
Name:Ctnnd2
Synonyms:Catnd2, Nprap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1195966. Ctnnd2.

Subcellular locationi

Nucleus. Cell junctionadherens junction
Note: Colocalizes with CDK5 in the cell body of neuronal cells.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12471247Catenin delta-2PRO_0000064300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei513 – 5131Phosphotyrosine1 Publication
Modified residuei1098 – 10981Phosphoserine1 Publication

Post-translational modificationi

O-glycosylated.1 Publication
Phosphorylated by CDK5.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35927.
PaxDbiO35927.
PRIDEiO35927.

PTM databases

PhosphoSiteiO35927.

Expressioni

Tissue specificityi

Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions.2 Publications

Developmental stagei

Increasingly expressed by embryonic day E10. Expression peaks at postnatal day P7 and stays at lower levels in adulthood. First expressed within proliferating neuronal progenitor cells of the neuroepithelium, becomes down-regulated during neuronal migration, and is later reexpressed in the dendritic compartment of postmitotic neurons. In the developing neocortex, it is strongly expressed in the proliferative ventricular zone and the developing cortical plate, yet is conspicuously less prominent in the intermediate zone, which contains migrating cortical neurons, it forms a honeycomb pattern in the neuroepithelium by labeling the cell periphery in a typical adherens junction pattern. By E18, its expression shifts primarily to nascent apical dendrites, a pattern that continues through adulthood.

Inductioni

By retinoic acid.1 Publication

Gene expression databases

BgeeiO35927.
CleanExiMM_CTNND2.
ExpressionAtlasiO35927. baseline and differential.
GenevestigatoriO35927.

Interactioni

Subunit structurei

Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Binds to PSEN1. Interacts with PDZD2. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) By similarity. Interacts with ZBTB33. Interacts with ARHGEF28.By similarity3 Publications

Protein-protein interaction databases

BioGridi201832. 1 interaction.
IntActiO35927. 4 interactions.
MINTiMINT-4092555.

Structurei

3D structure databases

ProteinModelPortaliO35927.
SMRiO35927. Positions 539-1058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati391 – 43343ARM 1Add
BLAST
Repeati537 – 57640ARM 2Add
BLAST
Repeati579 – 61840ARM 3Add
BLAST
Repeati623 – 66341ARM 4Add
BLAST
Repeati679 – 72143ARM 5Add
BLAST
Repeati725 – 77046ARM 6Add
BLAST
Repeati832 – 87241ARM 7Add
BLAST
Repeati904 – 94340ARM 8Add
BLAST
Repeati997 – 104044ARM 9Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili49 – 8436Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 2258Poly-Pro
Compositional biasi245 – 2484Poly-Ala
Compositional biasi478 – 4814Poly-Ala
Compositional biasi808 – 8147Poly-Lys

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG276924.
HOGENOMiHOG000231863.
HOVERGENiHBG004284.
InParanoidiO35927.
PhylomeDBiO35927.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PfamiPF00514. Arm. 4 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O35927-1) [UniParc]FASTAAdd to Basket

Also known as: NPRAPa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA
60 70 80 90 100
ILASVKEQEL QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAGE
110 120 130 140 150
QFHWQTQDGQ KDIEDELTTG LELVDSCIRS LQESGILDPQ DYSTSERPSL
160 170 180 190 200
LSQSALQLNS KPEGSFQYPA SYHSNQTLAL GDTAPSQLPA RSTQARAAGQ
210 220 230 240 250
SFSQGTTGRA GHLAGSEPAP PPPPPREPFA PSLGSAFHLP DAPPAAAALY
260 270 280 290 300
YSSSTLPAPP RGGSPLTTTQ GGSPTKLQRG GSAPEGAAYA APRGSSPKQS
310 320 330 340 350
PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQSTISS SPIHQLSSTI
360 370 380 390 400
GTYATLSPTK RLVHASEQYS KHSQELYATA TLQRPGSLAA GSRASYSSQH
410 420 430 440 450
GHLAPELRAL QSPEHHIDPI YEDRVYQKPP MRSLSQSQGD PLPPAHTGTF
460 470 480 490 500
RTSTAPSSPG VDSVPLQRTG SQHGPQNAAA ATFQRASYAA GPASNYADPY
510 520 530 540 550
RQLQYCASVD SPYSKSGPAL PPEGTLARSP SIDSIQKDPR EFGWRDPELP
560 570 580 590 600
EVIQMLQHQF PSVQSNAAAY LQHLCFGDNK IKAEIRRQGG IQLLVDLLDH
610 620 630 640 650
RMTEVHRSAC GALRNLVYGK ANDDNKIALK NCGGIPALVR LLRKTTDLEI
660 670 680 690 700
RELVTGVLWN LSSCDALKMP IIQDALAVLT NAVIIPHSGW ENSPLQDDRK
710 720 730 740 750
IQLHSSQVLR NATGCLRNVS SAGEEARRRM RECDGLTDAL LYVIQSALGS
760 770 780 790 800
SEIDSKTVEN CVCILRNLSY RLAAETSQGQ HMGTDELDGL LCGETNGKDT
810 820 830 840 850
ESSGCWGKKK KKKKSQDQWD GVGPLPDCAE PPKGIQMLWH PSIVKPYLTL
860 870 880 890 900
LSECSNPDTL EGAAGALQNL AAGSWKGWAE DVAGMAYALR SLPEGAPCLP
910 920 930 940 950
QWSVYIRAAV RKEKGLPILV ELLRIDNDRV VCAVATALRN MALDVRNKEL
960 970 980 990 1000
IGKYAMRDLV HRLPGGNNSN NSGSKAMSDD TVTAVCCTLH EVITKNMENA
1010 1020 1030 1040 1050
KALRDAGGIE KLVGISKSKG DKHSPKVVKA ASQVLNSMWQ YRDLRSLYKK
1060 1070 1080 1090 1100
DGWSQYHFVA SSSTIERDRQ RPYSSSRTPS ISPVRVSPNN RSASAPASPR
1110 1120 1130 1140 1150
EMISLKERKT DYESAGNNAT YHGTKGEHTS RKDTMTAQNT GVSTLYRNSY
1160 1170 1180 1190 1200
GAPAEDIKQN QVSTQPVPQE PSRKDYETYQ PFPNSTRNYD ESFFEDQVHH
1210 1220 1230 1240
RPPASEYTMH LGLKSTGNYV DFYSAARPYS ELNYETSHYP ASPDSWV
Length:1,247
Mass (Da):135,000
Last modified:January 1, 1998 - v1
Checksum:iD4A7A6B6A27D2919
GO
Isoform 2 (identifier: O35927-2) [UniParc]FASTAAdd to Basket

Also known as: NPRAPb

The sequence of this isoform differs from the canonical sequence as follows:
     878-902: Missing.

Show »
Length:1,222
Mass (Da):132,286
Checksum:i9570D985F604C41B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei878 – 90225Missing in isoform 2. CuratedVSP_006747Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90331 mRNA. Translation: AAB82409.1.
BC138260 mRNA. Translation: AAI38261.1.
BC138261 mRNA. Translation: AAI38262.1.
PIRiT42209.
RefSeqiNP_032755.2. NM_008729.2.
UniGeneiMm.321648.

Genome annotation databases

GeneIDi18163.
KEGGimmu:18163.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90331 mRNA. Translation: AAB82409.1 .
BC138260 mRNA. Translation: AAI38261.1 .
BC138261 mRNA. Translation: AAI38262.1 .
PIRi T42209.
RefSeqi NP_032755.2. NM_008729.2.
UniGenei Mm.321648.

3D structure databases

ProteinModelPortali O35927.
SMRi O35927. Positions 539-1058.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201832. 1 interaction.
IntActi O35927. 4 interactions.
MINTi MINT-4092555.

PTM databases

PhosphoSitei O35927.

Proteomic databases

MaxQBi O35927.
PaxDbi O35927.
PRIDEi O35927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 18163.
KEGGi mmu:18163.

Organism-specific databases

CTDi 1501.
MGIi MGI:1195966. Ctnnd2.

Phylogenomic databases

eggNOGi NOG276924.
HOGENOMi HOG000231863.
HOVERGENi HBG004284.
InParanoidi O35927.
PhylomeDBi O35927.

Miscellaneous databases

ChiTaRSi CTNND2. mouse.
NextBioi 293442.
PROi O35927.
SOURCEi Search...

Gene expression databases

Bgeei O35927.
CleanExi MM_CTNND2.
ExpressionAtlasi O35927. baseline and differential.
Genevestigatori O35927.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view ]
PANTHERi PTHR10372. PTHR10372. 1 hit.
Pfami PF00514. Arm. 4 hits.
[Graphical view ]
SMARTi SM00185. ARM. 7 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family."
    Paffenholz R., Franke W.W.
    Differentiation 61:293-304(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Delta-catenin, an adhesive junction-associated protein which promotes cell scattering."
    Lu Q., Paredes M., Medina M., Zhou J., Cavallo R., Peifer M., Orecchio L., Kosik K.S.
    J. Cell Biol. 144:519-532(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH E-CADHERIN.
    Tissue: Brain.
  4. "Expression of the mRNA for two isoforms of neural plakophilin-related arm-repeat protein/delta-catenin in rodent neurons and glial cells."
    Kawamura Y., Fan Q.W., Hayashi H., Michikawa M., Yanagisawa K., Komano H.
    Neurosci. Lett. 277:185-188(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), INDUCTION.
  5. "Delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development."
    Ho C., Zhou J., Medina M., Goto T., Jacobson M., Bhide P.G., Kosik K.S.
    J. Comp. Neurol. 420:261-276(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  6. "Regulation of the rapsyn promoter by kaiso and delta-catenin."
    Rodova M., Kelly K.F., VanSaun M., Daniel J.M., Werle M.J.
    Mol. Cell. Biol. 24:7188-7196(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ZBTB33, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1098, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  9. "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
    Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  10. "Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation."
    Kim H., Han J.-R., Park J., Oh M., James S.E., Chang S., Lu Q., Lee K.Y., Ki H., Song W.-J., Kim K.
    J. Biol. Chem. 283:977-987(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGEF28.
  11. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-513, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCTND2_MOUSE
AccessioniPrimary (citable) accession number: O35927
Secondary accession number(s): B2RR80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3