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Protein

Catenin delta-2

Gene

Ctnnd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:17993462) (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (PubMed:15282317).By similarity5 Publications

GO - Molecular functioni

GO - Biological processi

  • dendritic spine morphogenesis Source: MGI
  • learning Source: MGI
  • morphogenesis of a branching structure Source: MGI
  • regulation of canonical Wnt signaling pathway Source: MGI
  • regulation of synaptic plasticity Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • single organismal cell-cell adhesion Source: InterPro
  • synapse organization Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin delta-2
Alternative name(s):
Neural plakophilin-related ARM-repeat protein
Short name:
NPRAP
Neurojungin
Gene namesi
Name:Ctnnd2
Synonyms:Catnd2, Nprap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1195966. Ctnnd2.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: UniProtKB-SubCell
  • dendrite Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • perikaryon Source: UniProtKB
  • postsynaptic density Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643001 – 1247Catenin delta-2Add BLAST1247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei209Omega-N-methylarginineCombined sources1
Modified residuei261Omega-N-methylarginineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei279Omega-N-methylarginineCombined sources1
Modified residuei293Omega-N-methylarginineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei513PhosphotyrosineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1

Post-translational modificationi

O-glycosylated.1 Publication
Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B (PubMed:19706605).By similarity1 Publication

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

MaxQBiO35927.
PaxDbiO35927.
PRIDEiO35927.

PTM databases

iPTMnetiO35927.
PhosphoSitePlusiO35927.
SwissPalmiO35927.

Expressioni

Tissue specificityi

Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions.2 Publications

Developmental stagei

Increasingly expressed by embryonic day E10. Expression peaks at postnatal day P7 and stays at lower levels in adulthood. First expressed within proliferating neuronal progenitor cells of the neuroepithelium, becomes down-regulated during neuronal migration, and is later reexpressed in the dendritic compartment of postmitotic neurons. In the developing neocortex, it is strongly expressed in the proliferative ventricular zone and the developing cortical plate, yet is conspicuously less prominent in the intermediate zone, which contains migrating cortical neurons, it forms a honeycomb pattern in the neuroepithelium by labeling the cell periphery in a typical adherens junction pattern. By E18, its expression shifts primarily to nascent apical dendrites, a pattern that continues through adulthood.

Inductioni

By retinoic acid.1 Publication

Gene expression databases

BgeeiENSMUSG00000022240.
CleanExiMM_CTNND2.

Interactioni

Subunit structurei

Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Binds to PSEN1. Interacts with PDZD2 (By similarity). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) (By similarity). Interacts with ZBTB33. Interacts with ARHGEF28 (PubMed:17993462). Interacts with CDK5 (By similarity). Interacts with CTNNB1 (By similarity). Interacts with GSK3A and GSK3B (PubMed:20623542) (PubMed:19706605). Interacts with DNM2 (By similarity).By similarity5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201832. 1 interactor.
IntActiO35927. 5 interactors.
MINTiMINT-4092555.
STRINGi10090.ENSMUSP00000080427.

Structurei

3D structure databases

ProteinModelPortaliO35927.
SMRiO35927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati391 – 433ARM 1Add BLAST43
Repeati537 – 576ARM 2Add BLAST40
Repeati579 – 618ARM 3Add BLAST40
Repeati623 – 663ARM 4Add BLAST41
Repeati679 – 721ARM 5Add BLAST43
Repeati725 – 770ARM 6Add BLAST46
Repeati832 – 872ARM 7Add BLAST41
Repeati904 – 943ARM 8Add BLAST40
Repeati997 – 1040ARM 9Add BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 84Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 225Poly-Pro8
Compositional biasi245 – 248Poly-Ala4
Compositional biasi478 – 481Poly-Ala4
Compositional biasi808 – 814Poly-Lys7

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
HOGENOMiHOG000231863.
HOVERGENiHBG004284.
InParanoidiO35927.
PhylomeDBiO35927.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 3 hits.
PfamiPF00514. Arm. 4 hits.
[Graphical view]
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O35927-1) [UniParc]FASTAAdd to basket
Also known as: NPRAPa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA
60 70 80 90 100
ILASVKEQEL QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAGE
110 120 130 140 150
QFHWQTQDGQ KDIEDELTTG LELVDSCIRS LQESGILDPQ DYSTSERPSL
160 170 180 190 200
LSQSALQLNS KPEGSFQYPA SYHSNQTLAL GDTAPSQLPA RSTQARAAGQ
210 220 230 240 250
SFSQGTTGRA GHLAGSEPAP PPPPPREPFA PSLGSAFHLP DAPPAAAALY
260 270 280 290 300
YSSSTLPAPP RGGSPLTTTQ GGSPTKLQRG GSAPEGAAYA APRGSSPKQS
310 320 330 340 350
PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQSTISS SPIHQLSSTI
360 370 380 390 400
GTYATLSPTK RLVHASEQYS KHSQELYATA TLQRPGSLAA GSRASYSSQH
410 420 430 440 450
GHLAPELRAL QSPEHHIDPI YEDRVYQKPP MRSLSQSQGD PLPPAHTGTF
460 470 480 490 500
RTSTAPSSPG VDSVPLQRTG SQHGPQNAAA ATFQRASYAA GPASNYADPY
510 520 530 540 550
RQLQYCASVD SPYSKSGPAL PPEGTLARSP SIDSIQKDPR EFGWRDPELP
560 570 580 590 600
EVIQMLQHQF PSVQSNAAAY LQHLCFGDNK IKAEIRRQGG IQLLVDLLDH
610 620 630 640 650
RMTEVHRSAC GALRNLVYGK ANDDNKIALK NCGGIPALVR LLRKTTDLEI
660 670 680 690 700
RELVTGVLWN LSSCDALKMP IIQDALAVLT NAVIIPHSGW ENSPLQDDRK
710 720 730 740 750
IQLHSSQVLR NATGCLRNVS SAGEEARRRM RECDGLTDAL LYVIQSALGS
760 770 780 790 800
SEIDSKTVEN CVCILRNLSY RLAAETSQGQ HMGTDELDGL LCGETNGKDT
810 820 830 840 850
ESSGCWGKKK KKKKSQDQWD GVGPLPDCAE PPKGIQMLWH PSIVKPYLTL
860 870 880 890 900
LSECSNPDTL EGAAGALQNL AAGSWKGWAE DVAGMAYALR SLPEGAPCLP
910 920 930 940 950
QWSVYIRAAV RKEKGLPILV ELLRIDNDRV VCAVATALRN MALDVRNKEL
960 970 980 990 1000
IGKYAMRDLV HRLPGGNNSN NSGSKAMSDD TVTAVCCTLH EVITKNMENA
1010 1020 1030 1040 1050
KALRDAGGIE KLVGISKSKG DKHSPKVVKA ASQVLNSMWQ YRDLRSLYKK
1060 1070 1080 1090 1100
DGWSQYHFVA SSSTIERDRQ RPYSSSRTPS ISPVRVSPNN RSASAPASPR
1110 1120 1130 1140 1150
EMISLKERKT DYESAGNNAT YHGTKGEHTS RKDTMTAQNT GVSTLYRNSY
1160 1170 1180 1190 1200
GAPAEDIKQN QVSTQPVPQE PSRKDYETYQ PFPNSTRNYD ESFFEDQVHH
1210 1220 1230 1240
RPPASEYTMH LGLKSTGNYV DFYSAARPYS ELNYETSHYP ASPDSWV
Length:1,247
Mass (Da):135,000
Last modified:January 1, 1998 - v1
Checksum:iD4A7A6B6A27D2919
GO
Isoform 2 (identifier: O35927-2) [UniParc]FASTAAdd to basket
Also known as: NPRAPb

The sequence of this isoform differs from the canonical sequence as follows:
     878-902: Missing.

Show »
Length:1,222
Mass (Da):132,286
Checksum:i9570D985F604C41B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006747878 – 902Missing in isoform 2. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90331 mRNA. Translation: AAB82409.1.
BC138260 mRNA. Translation: AAI38261.1.
BC138261 mRNA. Translation: AAI38262.1.
PIRiT42209.
RefSeqiNP_032755.2. NM_008729.2.
UniGeneiMm.321648.

Genome annotation databases

GeneIDi18163.
KEGGimmu:18163.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90331 mRNA. Translation: AAB82409.1.
BC138260 mRNA. Translation: AAI38261.1.
BC138261 mRNA. Translation: AAI38262.1.
PIRiT42209.
RefSeqiNP_032755.2. NM_008729.2.
UniGeneiMm.321648.

3D structure databases

ProteinModelPortaliO35927.
SMRiO35927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201832. 1 interactor.
IntActiO35927. 5 interactors.
MINTiMINT-4092555.
STRINGi10090.ENSMUSP00000080427.

PTM databases

iPTMnetiO35927.
PhosphoSitePlusiO35927.
SwissPalmiO35927.

Proteomic databases

MaxQBiO35927.
PaxDbiO35927.
PRIDEiO35927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18163.
KEGGimmu:18163.

Organism-specific databases

CTDi1501.
MGIiMGI:1195966. Ctnnd2.

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
HOGENOMiHOG000231863.
HOVERGENiHBG004284.
InParanoidiO35927.
PhylomeDBiO35927.

Miscellaneous databases

ChiTaRSiCtnnd2. mouse.
PROiO35927.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022240.
CleanExiMM_CTNND2.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 3 hits.
PfamiPF00514. Arm. 4 hits.
[Graphical view]
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTND2_MOUSE
AccessioniPrimary (citable) accession number: O35927
Secondary accession number(s): B2RR80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.