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O35927

- CTND2_MOUSE

UniProt

O35927 - CTND2_MOUSE

Protein

Catenin delta-2

Gene

Ctnnd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33.2 Publications

    GO - Biological processi

    1. learning Source: MGI
    2. morphogenesis of a branching structure Source: MGI
    3. multicellular organismal development Source: UniProtKB-KW
    4. regulation of synaptic plasticity Source: MGI
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. single organismal cell-cell adhesion Source: InterPro
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell adhesion, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catenin delta-2
    Alternative name(s):
    Neural plakophilin-related ARM-repeat protein
    Short name:
    NPRAP
    Neurojungin
    Gene namesi
    Name:Ctnnd2
    Synonyms:Catnd2, Nprap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1195966. Ctnnd2.

    Subcellular locationi

    Nucleus. Cell junctionadherens junction
    Note: Colocalizes with CDK5 in the cell body of neuronal cells.By similarity

    GO - Cellular componenti

    1. adherens junction Source: UniProtKB-SubCell
    2. neuron projection Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. postsynaptic density Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12471247Catenin delta-2PRO_0000064300Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei513 – 5131Phosphotyrosine1 Publication
    Modified residuei1098 – 10981Phosphoserine1 Publication

    Post-translational modificationi

    O-glycosylated.1 Publication
    Phosphorylated by CDK5.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO35927.
    PaxDbiO35927.
    PRIDEiO35927.

    PTM databases

    PhosphoSiteiO35927.

    Expressioni

    Tissue specificityi

    Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions.2 Publications

    Developmental stagei

    Increasingly expressed by embryonic day E10. Expression peaks at postnatal day P7 and stays at lower levels in adulthood. First expressed within proliferating neuronal progenitor cells of the neuroepithelium, becomes down-regulated during neuronal migration, and is later reexpressed in the dendritic compartment of postmitotic neurons. In the developing neocortex, it is strongly expressed in the proliferative ventricular zone and the developing cortical plate, yet is conspicuously less prominent in the intermediate zone, which contains migrating cortical neurons, it forms a honeycomb pattern in the neuroepithelium by labeling the cell periphery in a typical adherens junction pattern. By E18, its expression shifts primarily to nascent apical dendrites, a pattern that continues through adulthood.

    Inductioni

    By retinoic acid.1 Publication

    Gene expression databases

    ArrayExpressiO35927.
    BgeeiO35927.
    CleanExiMM_CTNND2.
    GenevestigatoriO35927.

    Interactioni

    Subunit structurei

    Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Binds to PSEN1. Interacts with PDZD2. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) By similarity. Interacts with ZBTB33. Interacts with ARHGEF28.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi201832. 1 interaction.
    IntActiO35927. 4 interactions.
    MINTiMINT-4092555.

    Structurei

    3D structure databases

    ProteinModelPortaliO35927.
    SMRiO35927. Positions 539-1058.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati391 – 43343ARM 1Add
    BLAST
    Repeati537 – 57640ARM 2Add
    BLAST
    Repeati579 – 61840ARM 3Add
    BLAST
    Repeati623 – 66341ARM 4Add
    BLAST
    Repeati679 – 72143ARM 5Add
    BLAST
    Repeati725 – 77046ARM 6Add
    BLAST
    Repeati832 – 87241ARM 7Add
    BLAST
    Repeati904 – 94340ARM 8Add
    BLAST
    Repeati997 – 104044ARM 9Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili49 – 8436Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi218 – 2258Poly-Pro
    Compositional biasi245 – 2484Poly-Ala
    Compositional biasi478 – 4814Poly-Ala
    Compositional biasi808 – 8147Poly-Lys

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 9 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG276924.
    HOGENOMiHOG000231863.
    HOVERGENiHBG004284.
    PhylomeDBiO35927.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR028435. Plakophilin/d_Catenin.
    [Graphical view]
    PANTHERiPTHR10372. PTHR10372. 1 hit.
    PfamiPF00514. Arm. 4 hits.
    [Graphical view]
    SMARTiSM00185. ARM. 7 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35927-1) [UniParc]FASTAAdd to Basket

    Also known as: NPRAPa

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA     50
    ILASVKEQEL QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAGE 100
    QFHWQTQDGQ KDIEDELTTG LELVDSCIRS LQESGILDPQ DYSTSERPSL 150
    LSQSALQLNS KPEGSFQYPA SYHSNQTLAL GDTAPSQLPA RSTQARAAGQ 200
    SFSQGTTGRA GHLAGSEPAP PPPPPREPFA PSLGSAFHLP DAPPAAAALY 250
    YSSSTLPAPP RGGSPLTTTQ GGSPTKLQRG GSAPEGAAYA APRGSSPKQS 300
    PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQSTISS SPIHQLSSTI 350
    GTYATLSPTK RLVHASEQYS KHSQELYATA TLQRPGSLAA GSRASYSSQH 400
    GHLAPELRAL QSPEHHIDPI YEDRVYQKPP MRSLSQSQGD PLPPAHTGTF 450
    RTSTAPSSPG VDSVPLQRTG SQHGPQNAAA ATFQRASYAA GPASNYADPY 500
    RQLQYCASVD SPYSKSGPAL PPEGTLARSP SIDSIQKDPR EFGWRDPELP 550
    EVIQMLQHQF PSVQSNAAAY LQHLCFGDNK IKAEIRRQGG IQLLVDLLDH 600
    RMTEVHRSAC GALRNLVYGK ANDDNKIALK NCGGIPALVR LLRKTTDLEI 650
    RELVTGVLWN LSSCDALKMP IIQDALAVLT NAVIIPHSGW ENSPLQDDRK 700
    IQLHSSQVLR NATGCLRNVS SAGEEARRRM RECDGLTDAL LYVIQSALGS 750
    SEIDSKTVEN CVCILRNLSY RLAAETSQGQ HMGTDELDGL LCGETNGKDT 800
    ESSGCWGKKK KKKKSQDQWD GVGPLPDCAE PPKGIQMLWH PSIVKPYLTL 850
    LSECSNPDTL EGAAGALQNL AAGSWKGWAE DVAGMAYALR SLPEGAPCLP 900
    QWSVYIRAAV RKEKGLPILV ELLRIDNDRV VCAVATALRN MALDVRNKEL 950
    IGKYAMRDLV HRLPGGNNSN NSGSKAMSDD TVTAVCCTLH EVITKNMENA 1000
    KALRDAGGIE KLVGISKSKG DKHSPKVVKA ASQVLNSMWQ YRDLRSLYKK 1050
    DGWSQYHFVA SSSTIERDRQ RPYSSSRTPS ISPVRVSPNN RSASAPASPR 1100
    EMISLKERKT DYESAGNNAT YHGTKGEHTS RKDTMTAQNT GVSTLYRNSY 1150
    GAPAEDIKQN QVSTQPVPQE PSRKDYETYQ PFPNSTRNYD ESFFEDQVHH 1200
    RPPASEYTMH LGLKSTGNYV DFYSAARPYS ELNYETSHYP ASPDSWV 1247
    Length:1,247
    Mass (Da):135,000
    Last modified:January 1, 1998 - v1
    Checksum:iD4A7A6B6A27D2919
    GO
    Isoform 2 (identifier: O35927-2) [UniParc]FASTAAdd to Basket

    Also known as: NPRAPb

    The sequence of this isoform differs from the canonical sequence as follows:
         878-902: Missing.

    Show »
    Length:1,222
    Mass (Da):132,286
    Checksum:i9570D985F604C41B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei878 – 90225Missing in isoform 2. CuratedVSP_006747Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90331 mRNA. Translation: AAB82409.1.
    BC138260 mRNA. Translation: AAI38261.1.
    BC138261 mRNA. Translation: AAI38262.1.
    PIRiT42209.
    RefSeqiNP_032755.2. NM_008729.2.
    UniGeneiMm.321648.

    Genome annotation databases

    GeneIDi18163.
    KEGGimmu:18163.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90331 mRNA. Translation: AAB82409.1 .
    BC138260 mRNA. Translation: AAI38261.1 .
    BC138261 mRNA. Translation: AAI38262.1 .
    PIRi T42209.
    RefSeqi NP_032755.2. NM_008729.2.
    UniGenei Mm.321648.

    3D structure databases

    ProteinModelPortali O35927.
    SMRi O35927. Positions 539-1058.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201832. 1 interaction.
    IntActi O35927. 4 interactions.
    MINTi MINT-4092555.

    PTM databases

    PhosphoSitei O35927.

    Proteomic databases

    MaxQBi O35927.
    PaxDbi O35927.
    PRIDEi O35927.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 18163.
    KEGGi mmu:18163.

    Organism-specific databases

    CTDi 1501.
    MGIi MGI:1195966. Ctnnd2.

    Phylogenomic databases

    eggNOGi NOG276924.
    HOGENOMi HOG000231863.
    HOVERGENi HBG004284.
    PhylomeDBi O35927.

    Miscellaneous databases

    ChiTaRSi CTNND2. mouse.
    NextBioi 293442.
    PROi O35927.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35927.
    Bgeei O35927.
    CleanExi MM_CTNND2.
    Genevestigatori O35927.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR028435. Plakophilin/d_Catenin.
    [Graphical view ]
    PANTHERi PTHR10372. PTHR10372. 1 hit.
    Pfami PF00514. Arm. 4 hits.
    [Graphical view ]
    SMARTi SM00185. ARM. 7 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family."
      Paffenholz R., Franke W.W.
      Differentiation 61:293-304(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
      Tissue: Fetal brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Delta-catenin, an adhesive junction-associated protein which promotes cell scattering."
      Lu Q., Paredes M., Medina M., Zhou J., Cavallo R., Peifer M., Orecchio L., Kosik K.S.
      J. Cell Biol. 144:519-532(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH E-CADHERIN.
      Tissue: Brain.
    4. "Expression of the mRNA for two isoforms of neural plakophilin-related arm-repeat protein/delta-catenin in rodent neurons and glial cells."
      Kawamura Y., Fan Q.W., Hayashi H., Michikawa M., Yanagisawa K., Komano H.
      Neurosci. Lett. 277:185-188(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), INDUCTION.
    5. "Delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development."
      Ho C., Zhou J., Medina M., Goto T., Jacobson M., Bhide P.G., Kosik K.S.
      J. Comp. Neurol. 420:261-276(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    6. "Regulation of the rapsyn promoter by kaiso and delta-catenin."
      Rodova M., Kelly K.F., VanSaun M., Daniel J.M., Werle M.J.
      Mol. Cell. Biol. 24:7188-7196(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ZBTB33, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1098, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    9. "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
      Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    10. "Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation."
      Kim H., Han J.-R., Park J., Oh M., James S.E., Chang S., Lu Q., Lee K.Y., Ki H., Song W.-J., Kim K.
      J. Biol. Chem. 283:977-987(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARHGEF28.
    11. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-513, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiCTND2_MOUSE
    AccessioniPrimary (citable) accession number: O35927
    Secondary accession number(s): B2RR80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3