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O35927 (CTND2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catenin delta-2
Alternative name(s):
Neural plakophilin-related ARM-repeat protein
Short name=NPRAP
Neurojungin
Gene names
Name:Ctnnd2
Synonyms:Catnd2, Nprap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1247 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33. Ref.3 Ref.6

Subunit structure

Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Binds to PSEN1. Interacts with PDZD2. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) By similarity. Interacts with ZBTB33. Interacts with ARHGEF28. Ref.3 Ref.6 Ref.10

Subcellular location

Nucleus. Cell junctionadherens junction. Note: Colocalizes with CDK5 in the cell body of neuronal cells By similarity. Ref.5 Ref.6

Tissue specificity

Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform invarious brain regions. Expressed at neuromuscular junctions. Ref.5 Ref.6

Developmental stage

Increasingly expressed by embryonic day E10. Expression peaks at postnatal day P7 and stays at lower levels in adulthood. First expressed within proliferating neuronal progenitor cells of the neuroepithelium, becomes down-regulated during neuronal migration, and is later reexpressed in the dendritic compartment of postmitotic neurons. In the developing neocortex, it is strongly expressed in the proliferative ventricular zone and the developing cortical plate, yet is conspicuously less prominent in the intermediate zone, which contains migrating cortical neurons, it forms a honeycomb pattern in the neuroepithelium by labeling the cell periphery in a typical adherens junction pattern. By E18, its expression shifts primarily to nascent apical dendrites, a pattern that continues through adulthood.

Induction

By retinoic acid. Ref.4

Post-translational modification

O-glycosylated.

Phosphorylated by CDK5 By similarity.

Sequence similarities

Belongs to the beta-catenin family.

Contains 9 ARM repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O35927-1)

Also known as: NPRAPa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O35927-2)

Also known as: NPRAPb;

The sequence of this isoform differs from the canonical sequence as follows:
     878-902: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12471247Catenin delta-2
PRO_0000064300

Regions

Repeat391 – 43343ARM 1
Repeat537 – 57640ARM 2
Repeat579 – 61840ARM 3
Repeat623 – 66341ARM 4
Repeat679 – 72143ARM 5
Repeat725 – 77046ARM 6
Repeat832 – 87241ARM 7
Repeat904 – 94340ARM 8
Repeat997 – 104044ARM 9
Coiled coil49 – 8436 Potential
Compositional bias218 – 2258Poly-Pro
Compositional bias245 – 2484Poly-Ala
Compositional bias478 – 4814Poly-Ala
Compositional bias808 – 8147Poly-Lys

Amino acid modifications

Modified residue5131Phosphotyrosine Ref.11
Modified residue10981Phosphoserine Ref.8

Natural variations

Alternative sequence878 – 90225Missing in isoform 2.
VSP_006747

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (NPRAPa) [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D4A7A6B6A27D2919

FASTA1,247135,000
        10         20         30         40         50         60 
MFARKQSGAA PFGAMPVPDQ PPSASEKNSS LSPGLNTSNG DGSETETTSA ILASVKEQEL 

        70         80         90        100        110        120 
QFERLTRELE AERQIVASQL ERCKLGSETG SMSSISSAGE QFHWQTQDGQ KDIEDELTTG 

       130        140        150        160        170        180 
LELVDSCIRS LQESGILDPQ DYSTSERPSL LSQSALQLNS KPEGSFQYPA SYHSNQTLAL 

       190        200        210        220        230        240 
GDTAPSQLPA RSTQARAAGQ SFSQGTTGRA GHLAGSEPAP PPPPPREPFA PSLGSAFHLP 

       250        260        270        280        290        300 
DAPPAAAALY YSSSTLPAPP RGGSPLTTTQ GGSPTKLQRG GSAPEGAAYA APRGSSPKQS 

       310        320        330        340        350        360 
PSRLAKSYST SSPINIVVSS AGLSPIRVTS PPTVQSTISS SPIHQLSSTI GTYATLSPTK 

       370        380        390        400        410        420 
RLVHASEQYS KHSQELYATA TLQRPGSLAA GSRASYSSQH GHLAPELRAL QSPEHHIDPI 

       430        440        450        460        470        480 
YEDRVYQKPP MRSLSQSQGD PLPPAHTGTF RTSTAPSSPG VDSVPLQRTG SQHGPQNAAA 

       490        500        510        520        530        540 
ATFQRASYAA GPASNYADPY RQLQYCASVD SPYSKSGPAL PPEGTLARSP SIDSIQKDPR 

       550        560        570        580        590        600 
EFGWRDPELP EVIQMLQHQF PSVQSNAAAY LQHLCFGDNK IKAEIRRQGG IQLLVDLLDH 

       610        620        630        640        650        660 
RMTEVHRSAC GALRNLVYGK ANDDNKIALK NCGGIPALVR LLRKTTDLEI RELVTGVLWN 

       670        680        690        700        710        720 
LSSCDALKMP IIQDALAVLT NAVIIPHSGW ENSPLQDDRK IQLHSSQVLR NATGCLRNVS 

       730        740        750        760        770        780 
SAGEEARRRM RECDGLTDAL LYVIQSALGS SEIDSKTVEN CVCILRNLSY RLAAETSQGQ 

       790        800        810        820        830        840 
HMGTDELDGL LCGETNGKDT ESSGCWGKKK KKKKSQDQWD GVGPLPDCAE PPKGIQMLWH 

       850        860        870        880        890        900 
PSIVKPYLTL LSECSNPDTL EGAAGALQNL AAGSWKGWAE DVAGMAYALR SLPEGAPCLP 

       910        920        930        940        950        960 
QWSVYIRAAV RKEKGLPILV ELLRIDNDRV VCAVATALRN MALDVRNKEL IGKYAMRDLV 

       970        980        990       1000       1010       1020 
HRLPGGNNSN NSGSKAMSDD TVTAVCCTLH EVITKNMENA KALRDAGGIE KLVGISKSKG 

      1030       1040       1050       1060       1070       1080 
DKHSPKVVKA ASQVLNSMWQ YRDLRSLYKK DGWSQYHFVA SSSTIERDRQ RPYSSSRTPS 

      1090       1100       1110       1120       1130       1140 
ISPVRVSPNN RSASAPASPR EMISLKERKT DYESAGNNAT YHGTKGEHTS RKDTMTAQNT 

      1150       1160       1170       1180       1190       1200 
GVSTLYRNSY GAPAEDIKQN QVSTQPVPQE PSRKDYETYQ PFPNSTRNYD ESFFEDQVHH 

      1210       1220       1230       1240 
RPPASEYTMH LGLKSTGNYV DFYSAARPYS ELNYETSHYP ASPDSWV 

« Hide

Isoform 2 (NPRAPb) [UniParc].

Checksum: 9570D985F604C41B
Show »

FASTA1,222132,286

References

« Hide 'large scale' references
[1]"Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family."
Paffenholz R., Franke W.W.
Differentiation 61:293-304(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
Tissue: Fetal brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Delta-catenin, an adhesive junction-associated protein which promotes cell scattering."
Lu Q., Paredes M., Medina M., Zhou J., Cavallo R., Peifer M., Orecchio L., Kosik K.S.
J. Cell Biol. 144:519-532(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH E-CADHERIN.
Tissue: Brain.
[4]"Expression of the mRNA for two isoforms of neural plakophilin-related arm-repeat protein/delta-catenin in rodent neurons and glial cells."
Kawamura Y., Fan Q.W., Hayashi H., Michikawa M., Yanagisawa K., Komano H.
Neurosci. Lett. 277:185-188(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), INDUCTION.
[5]"Delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development."
Ho C., Zhou J., Medina M., Goto T., Jacobson M., Bhide P.G., Kosik K.S.
J. Comp. Neurol. 420:261-276(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[6]"Regulation of the rapsyn promoter by kaiso and delta-catenin."
Rodova M., Kelly K.F., VanSaun M., Daniel J.M., Werle M.J.
Mol. Cell. Biol. 24:7188-7196(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ZBTB33, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
[8]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1098, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[9]"O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
Vosseller K., Trinidad J.C., Chalkley R.J., Specht C.G., Thalhammer A., Lynn A.J., Snedecor J.O., Guan S., Medzihradszky K.F., Maltby D.A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
Tissue: Brain.
[10]"Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation."
Kim H., Han J.-R., Park J., Oh M., James S.E., Chang S., Lu Q., Lee K.Y., Ki H., Song W.-J., Kim K.
J. Biol. Chem. 283:977-987(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARHGEF28.
[11]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-513, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U90331 mRNA. Translation: AAB82409.1.
BC138260 mRNA. Translation: AAI38261.1.
BC138261 mRNA. Translation: AAI38262.1.
PIRT42209.
RefSeqNP_032755.2. NM_008729.2.
UniGeneMm.321648.

3D structure databases

ProteinModelPortalO35927.
SMRO35927. Positions 539-1058.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201832. 1 interaction.
IntActO35927. 4 interactions.
MINTMINT-4092555.

PTM databases

PhosphoSiteO35927.

Proteomic databases

PaxDbO35927.
PRIDEO35927.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID18163.
KEGGmmu:18163.

Organism-specific databases

CTD1501.
MGIMGI:1195966. Ctnnd2.

Phylogenomic databases

eggNOGNOG276924.
HOGENOMHOG000231863.
HOVERGENHBG004284.
PhylomeDBO35927.

Gene expression databases

ArrayExpressO35927.
BgeeO35927.
CleanExMM_CTNND2.
GenevestigatorO35927.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERPTHR10372. PTHR10372. 1 hit.
PfamPF00514. Arm. 4 hits.
[Graphical view]
SMARTSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCTNND2. mouse.
NextBio293442.
PROO35927.
SOURCESearch...

Entry information

Entry nameCTND2_MOUSE
AccessionPrimary (citable) accession number: O35927
Secondary accession number(s): B2RR80
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot