Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase 5 activator 2

Gene

Cdk5r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activator of CDK5/TPKII.

GO - Molecular functioni

  • cyclin-dependent protein kinase 5 activator activity Source: MGI
  • cytoskeletal protein binding Source: MGI
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • cerebellum development Source: MGI
  • hippocampus development Source: MGI
  • layer formation in cerebral cortex Source: MGI
  • neuron migration Source: MGI
  • positive regulation of calcium ion-dependent exocytosis Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • superior olivary nucleus maturation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 activator 2
Short name:
CDK5 activator 2
Alternative name(s):
Cyclin-dependent kinase 5 regulatory subunit 2
p39
p39I
Gene namesi
Name:Cdk5r2
Synonyms:Nck5ai
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1330828. Cdk5r2.

Subcellular locationi

GO - Cellular componenti

  • cyclin-dependent protein kinase 5 holoenzyme complex Source: InterPro
  • cytoplasm Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 369Cyclin-dependent kinase 5 activator 2PRO_0000004803
Initiator methionineiRemoved
Propeptidei2 – ?Sequence analysisPRO_0000004802

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei84 – 841PhosphothreonineCombined sources

Post-translational modificationi

Myristoylated. The Gly-2-Ala mutant is absent of the cell periphery, suggesting that a proper myristoylation signal is essential for the proper distribution of CDK5R2 (p39) (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiO35926.
PaxDbiO35926.
PeptideAtlasiO35926.
PRIDEiO35926.

PTM databases

iPTMnetiO35926.
PhosphoSiteiO35926.

Expressioni

Gene expression databases

BgeeiENSMUSG00000090071.
GenevisibleiO35926. MM.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit and a regulatory subunit.

GO - Molecular functioni

  • cytoskeletal protein binding Source: MGI

Protein-protein interaction databases

MINTiMINT-246909.
STRINGi10090.ENSMUSP00000125322.

Structurei

3D structure databases

ProteinModelPortaliO35926.
SMRiO35926. Positions 180-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 784Poly-Lys
Compositional biasi155 – 1639Poly-Pro
Compositional biasi348 – 3514Poly-Ser

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3932. Eukaryota.
ENOG410YFUI. LUCA.
GeneTreeiENSGT00390000008812.
HOGENOMiHOG000063677.
HOVERGENiHBG050853.
InParanoidiO35926.
KOiK19929.
OMAiGTKHWTM.
OrthoDBiEOG091G0OB3.
TreeFamiTF101036.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR004944. CDK5_activator.
IPR013763. Cyclin-like.
[Graphical view]
PANTHERiPTHR23401. PTHR23401. 1 hit.
PfamiPF03261. CDK5_activator. 1 hit.
[Graphical view]
PIRSFiPIRSF009324. Cdk5_activator. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPAGKGGKG
60 70 80 90 100
ESRLKRPSVL ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN
110 120 130 140 150
RENLLRKGRD GPDGGGTAKP LAVPVPTVPT TAATCEPPSG GSAAAPPPGS
160 170 180 190 200
GGGKPPPPPP PAPQAAPPAP GGSPRRVIVQ ASTGELLRCL GDFVCRRCYR
210 220 230 240 250
LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY LLCRESLRGD
260 270 280 290 300
ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL
310 320 330 340 350
IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASTGGPPS GSSASTTSSS
360
SARDSCATGA KHWTMNLDR
Length:369
Mass (Da):38,924
Last modified:July 27, 2011 - v2
Checksum:iD426300E88441D99
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911G → V in AAB69709 (Ref. 2) Curated
Sequence conflicti172 – 1721G → S in AAC53595 (PubMed:9655938).Curated
Sequence conflicti191 – 1911G → R in AAC53595 (PubMed:9655938).Curated
Sequence conflicti197 – 1971R → S in AAC53595 (PubMed:9655938).Curated
Sequence conflicti220 – 2201L → W in AAB69709 (Ref. 2) Curated
Sequence conflicti248 – 2481R → S in AAC53595 (PubMed:9655938).Curated
Sequence conflicti253 – 2531A → G in AAB69709 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90267 Genomic DNA. Translation: AAC53595.1.
AF016393 Genomic DNA. Translation: AAB69709.1.
AF071086 Genomic DNA. Translation: AAF14854.1.
CH466548 Genomic DNA. Translation: EDL00353.1.
CCDSiCCDS48290.1.
RefSeqiNP_034002.2. NM_009872.3.
UniGeneiMm.153833.

Genome annotation databases

EnsembliENSMUST00000160379; ENSMUSP00000125322; ENSMUSG00000090071.
GeneIDi12570.
KEGGimmu:12570.
UCSCiuc007bng.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90267 Genomic DNA. Translation: AAC53595.1.
AF016393 Genomic DNA. Translation: AAB69709.1.
AF071086 Genomic DNA. Translation: AAF14854.1.
CH466548 Genomic DNA. Translation: EDL00353.1.
CCDSiCCDS48290.1.
RefSeqiNP_034002.2. NM_009872.3.
UniGeneiMm.153833.

3D structure databases

ProteinModelPortaliO35926.
SMRiO35926. Positions 180-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-246909.
STRINGi10090.ENSMUSP00000125322.

PTM databases

iPTMnetiO35926.
PhosphoSiteiO35926.

Proteomic databases

MaxQBiO35926.
PaxDbiO35926.
PeptideAtlasiO35926.
PRIDEiO35926.

Protocols and materials databases

DNASUi12570.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160379; ENSMUSP00000125322; ENSMUSG00000090071.
GeneIDi12570.
KEGGimmu:12570.
UCSCiuc007bng.2. mouse.

Organism-specific databases

CTDi8941.
MGIiMGI:1330828. Cdk5r2.

Phylogenomic databases

eggNOGiKOG3932. Eukaryota.
ENOG410YFUI. LUCA.
GeneTreeiENSGT00390000008812.
HOGENOMiHOG000063677.
HOVERGENiHBG050853.
InParanoidiO35926.
KOiK19929.
OMAiGTKHWTM.
OrthoDBiEOG091G0OB3.
TreeFamiTF101036.

Miscellaneous databases

ChiTaRSiCdk5r2. mouse.
PROiO35926.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090071.
GenevisibleiO35926. MM.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR004944. CDK5_activator.
IPR013763. Cyclin-like.
[Graphical view]
PANTHERiPTHR23401. PTHR23401. 1 hit.
PfamiPF03261. CDK5_activator. 1 hit.
[Graphical view]
PIRSFiPIRSF009324. Cdk5_activator. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCD5R2_MOUSE
AccessioniPrimary (citable) accession number: O35926
Secondary accession number(s): O35277, Q9QYD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.