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Protein

Excitatory amino acid transporter 4

Gene

Slc1a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium (By similarity).By similarity

GO - Molecular functioni

  • anion transmembrane transporter activity Source: RGD
  • L-glutamate transmembrane transporter activity Source: RGD
  • sodium:dicarboxylate symporter activity Source: InterPro

GO - Biological processi

  • anion transmembrane transport Source: GOC
  • L-glutamate transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 4
Alternative name(s):
High-affinity neuronal glutamate transporter
Sodium-dependent glutamate/aspartate transporter
Solute carrier family 1 member 6
Gene namesi
Name:Slc1a6
Synonyms:Eaat4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620340. Slc1a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Topological domaini151 – 261111ExtracellularSequence analysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence analysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence analysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence analysisAdd
BLAST
Transmembranei457 – 47721HelicalSequence analysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Excitatory amino acid transporter 4PRO_0000202072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21PhosphoserineCombined sources
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35921.
PRIDEiO35921.

PTM databases

iPTMnetiO35921.
PhosphoSiteiO35921.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009931.

Structurei

3D structure databases

ProteinModelPortaliO35921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiO35921.
KOiK05617.
PhylomeDBiO35921.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHGNSLFL RESGAGGGCL QGLQDSLQQR ALRTRLRLQT MTREHVRRFL
60 70 80 90 100
RRNAFILLTV SAVIIGVSLA FALRPYQLTY RQIKYFSFPG ELLMRMLQML
110 120 130 140 150
VLPLIVSSRV TGMASLDNKA TGRMGMRAAV YYMVTTVIAV FIGILMVTII
160 170 180 190 200
HPGKGSKEGL HREGRIETVP TADAFMDLVR NMFPPNLVEA CFKQFKTQYS
210 220 230 240 250
TRVVTRTIVR TDNGSELGAS ISPPSSAENE TSILENVTRA LGTLQEVISF
260 270 280 290 300
EETVPVPGSA NGINALGLVV FSVAFGLVIG GMKHKGRVLR DFFDSLNEAI
310 320 330 340 350
MRLVGIIIWY APVGILFLIA GKILEMEDMA VLGGQLGMYT LTVIVGLFLH
360 370 380 390 400
AGGVLPLIYF LVTHRNPFPF IGGILQALIT AMGTSSSSAT LPITFRCLEE
410 420 430 440 450
GLGVDRRITR FVLPVGATVN MDGTALYEAL AAIFIAQVNN YELNLGQITT
460 470 480 490 500
ISITATAASV GAAGIPQAGL VTMVIVLTSV GLPTEDITLI IAVDWFLDRL
510 520 530 540 550
RTMTNVLGDS IGAAVIEHLS QRELELQEAE LTLPSLGKPY KSLMAQAKGA
560
SRGRGGNESV M
Length:561
Mass (Da):60,715
Last modified:January 1, 1998 - v1
Checksum:iAAF1298EE6AA8359
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191K → R in AAB40997 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89608 mRNA. Translation: AAB72086.1.
U80915 mRNA. Translation: AAB40997.1.
RefSeqiNP_114454.1. NM_032065.1.
UniGeneiRn.10827.

Genome annotation databases

GeneIDi84012.
KEGGirno:84012.
UCSCiRGD:620340. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89608 mRNA. Translation: AAB72086.1.
U80915 mRNA. Translation: AAB40997.1.
RefSeqiNP_114454.1. NM_032065.1.
UniGeneiRn.10827.

3D structure databases

ProteinModelPortaliO35921.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009931.

Chemistry

GuidetoPHARMACOLOGYi871.

PTM databases

iPTMnetiO35921.
PhosphoSiteiO35921.

Proteomic databases

PaxDbiO35921.
PRIDEiO35921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84012.
KEGGirno:84012.
UCSCiRGD:620340. rat.

Organism-specific databases

CTDi6511.
RGDi620340. Slc1a6.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiO35921.
KOiK05617.
PhylomeDBiO35921.

Miscellaneous databases

NextBioi616543.
PROiO35921.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Lin C.-L.G., Jin L., Rothstein J.D.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.
  2. Matthews J.C., Kilberg M.S., Novak D.A.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-305.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEAA4_RAT
AccessioniPrimary (citable) accession number: O35921
Secondary accession number(s): P97683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 20, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.