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Protein

Solute carrier organic anion transporter family member 1A4

Gene

Slco1a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones. May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides.

GO - Molecular functioni

GO - Biological processi

  • bile acid metabolic process Source: GO_Central
  • sodium-independent organic anion transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159418. Recycling of bile acids and salts.
R-RNO-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A4
Alternative name(s):
Brain digoxin carrier protein
Brain-specific organic anion transporter
OATP-B1
Sodium-independent organic anion-transporting polypeptide 2
Solute carrier family 21 member 5
Gene namesi
Name:Slco1a4
Synonyms:Oatp1a4, Oatp2, Slc21a5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621389. Slco1a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 111Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini112 – 154ExtracellularSequence analysisAdd BLAST43
Transmembranei155 – 183Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini184 – 202CytoplasmicSequence analysisAdd BLAST19
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 241ExtracellularSequence analysisAdd BLAST18
Transmembranei242 – 266Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini267 – 310CytoplasmicSequence analysisAdd BLAST44
Transmembranei311 – 332Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini333 – 352ExtracellularSequence analysisAdd BLAST20
Transmembranei353 – 376Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini377 – 380CytoplasmicSequence analysis4
Transmembranei381 – 404Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini405 – 512ExtracellularSequence analysisAdd BLAST108
Transmembranei513 – 535Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini536 – 544CytoplasmicSequence analysis9
Transmembranei545 – 570Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini571 – 604ExtracellularSequence analysisAdd BLAST34
Transmembranei605 – 622Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini623 – 661CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1781860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910471 – 661Solute carrier organic anion transporter family member 1A4Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi438 ↔ 464PROSITE-ProRule annotation
Disulfide bondi442 ↔ 453PROSITE-ProRule annotation
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi444 ↔ 468PROSITE-ProRule annotation
Glycosylationi482N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Modified residuei633PhosphoserineBy similarity1
Modified residuei634PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35913.
PRIDEiO35913.

Expressioni

Tissue specificityi

Highly expressed in brain, liver, and kidney but not expressed in heart, spleen, lung, skeletal muscle, and testis.

Gene expression databases

BgeeiENSRNOG00000047493.
GenevisibleiO35913. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040237.

Chemistry databases

BindingDBiO35913.

Structurei

3D structure databases

ProteinModelPortaliO35913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini432 – 487Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOVERGENiHBG063896.
InParanoidiO35913.
KOiK03460.
OMAiCHAGCKE.
OrthoDBiEOG091G08QD.
PhylomeDBiO35913.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSEKRVAT HGVRCFAKIK MFLLALTCAY VSKSLSGTYM NSMLTQIERQ
60 70 80 90 100
FGIPTSIVGL INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCAVMGLGC
110 120 130 140 150
FLISLPHFLM GQYEYETILP TSNVSSNSFF CVENRSQTLN PTQDPSECVK
160 170 180 190 200
EMKSLMWIYV LVGNIIRGIG ETPIMPLGIS YIEDFAKSEN SPLYIGILET
210 220 230 240 250
GMTIGPLIGL LLASSCANIY VDIESVNTDD LTITPTDTRW VGAWWIGFLV
260 270 280 290 300
CAGVNILTSF PFFFFPKTLP KEGLQENVDG TENAKEKKHR KKAKEEKRGI
310 320 330 340 350
TKDFFVFMKS LSCNPIYMLF ILISVLQFNA FINSFTFMPK YLEQQYGKST
360 370 380 390 400
AEVVFLMGLY MLPPICLGYL IGGLIMKKFK VTVKKAAHLA FWLCLSEYLL
410 420 430 440 450
SFLSYVMTCD NFPVAGLTTS YEGVQHQLYV ENKVLADCNT RCNCSTNTWD
460 470 480 490 500
PVCGDNGLAY MSACLAGCEK SVGTGTNMVF QNCSCIQSSG NSSAVLGLCN
510 520 530 540 550
KGPDCANKLQ YFLIIAIFGC FIYSLAGIPG YMVLLRCIKS EEKSLGVGLH
560 570 580 590 600
AFCIRILAGI PAPIYFGALI DRTCLHWGTL KCGEPGACRM YDINSFRRLY
610 620 630 640 650
LGLPAALRGA SFVPAFFILR LTRTFQFPGD IESSKTDHAE MKLTLKESEC
660
TEVLRSKVTE D
Length:661
Mass (Da):73,252
Last modified:January 1, 1998 - v1
Checksum:i692DA69FC85299D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti360Y → N in AAC32669 (PubMed:9712861).Curated1
Sequence conflicti617F → FF in AAC32669 (PubMed:9712861).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88036 mRNA. Translation: AAB80699.1.
U95011 mRNA. Translation: AAC32669.1.
RefSeqiNP_571981.1. NM_131906.1.
XP_017447901.1. XM_017592412.1.
UniGeneiRn.5641.

Genome annotation databases

EnsembliENSRNOT00000043374; ENSRNOP00000042595; ENSRNOG00000047493.
ENSRNOT00000046598; ENSRNOP00000040237; ENSRNOG00000047493.
GeneIDi170698.
KEGGirno:170698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88036 mRNA. Translation: AAB80699.1.
U95011 mRNA. Translation: AAC32669.1.
RefSeqiNP_571981.1. NM_131906.1.
XP_017447901.1. XM_017592412.1.
UniGeneiRn.5641.

3D structure databases

ProteinModelPortaliO35913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040237.

Chemistry databases

BindingDBiO35913.
ChEMBLiCHEMBL1781860.

Proteomic databases

PaxDbiO35913.
PRIDEiO35913.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043374; ENSRNOP00000042595; ENSRNOG00000047493.
ENSRNOT00000046598; ENSRNOP00000040237; ENSRNOG00000047493.
GeneIDi170698.
KEGGirno:170698.

Organism-specific databases

CTDi6579.
RGDi621389. Slco1a4.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOVERGENiHBG063896.
InParanoidiO35913.
KOiK03460.
OMAiCHAGCKE.
OrthoDBiEOG091G08QD.
PhylomeDBiO35913.

Enzyme and pathway databases

ReactomeiR-RNO-159418. Recycling of bile acids and salts.
R-RNO-879518. Transport of organic anions.

Miscellaneous databases

PROiO35913.

Gene expression databases

BgeeiENSRNOG00000047493.
GenevisibleiO35913. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1A4_RAT
AccessioniPrimary (citable) accession number: O35913
Secondary accession number(s): O55224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.