Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Epithelial membrane protein 3

Gene

Emp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in cell proliferation and cell-cell interactions.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 3
Short name:
EMP-3
Alternative name(s):
Hematopoietic neural membrane protein 1
Short name:
HNMP-1
Protein YMP
Gene namesi
Name:Emp3
Synonyms:Ymp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1098729. Emp3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Epithelial membrane protein 3PRO_0000164661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35912.
TopDownProteomicsiO35912.

PTM databases

PhosphoSiteiO35912.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040212.
CleanExiMM_EMP3.
GenevisibleiO35912. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037289.

Structurei

3D structure databases

ProteinModelPortaliO35912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiO35912.
OMAiSDLWYNC.
OrthoDBiEOG091G0RF4.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLLVVSA LHILILVLLF VATLDKSWWT LPDKESLNLW YDCTWNTTTQ
60 70 80 90 100
TWACSNVSEN GWLKAVQALM VLSLILCCLS FILFMFQLYT MRRGGLFYAT
110 120 130 140 150
GLCQLCTSAA VFSGALIYAI HTEEILAKHP SGGSFGYCFA LAWVAFPLAL
160
VSGTVYIHLR KRE
Length:163
Mass (Da):18,253
Last modified:October 3, 2012 - v2
Checksum:i91620FD4C6AEB70C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961L → I in AAC33407 (PubMed:9615230).Curated
Sequence conflicti106 – 1061C → W in AAC33407 (PubMed:9615230).Curated
Sequence conflicti129 – 1291H → Q in AAC33407 (PubMed:9615230).Curated
Sequence conflicti154 – 1552TV → IMY in AAC33407 (PubMed:9615230).Curated
Sequence conflicti154 – 1541T → I in AAC53324 (PubMed:9204931).Curated
Sequence conflicti154 – 1541T → I in AAH01999 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87948 mRNA. Translation: AAC53324.1.
AF011750 mRNA. Translation: AAC33407.1.
AK146939 mRNA. Translation: BAE27548.1.
AC149053 Genomic DNA. No translation available.
BC001999 mRNA. Translation: AAH01999.1.
CCDSiCCDS21270.1.
RefSeqiNP_001139818.1. NM_001146346.1.
NP_034259.2. NM_010129.2.
UniGeneiMm.20829.

Genome annotation databases

EnsembliENSMUST00000038876; ENSMUSP00000037289; ENSMUSG00000040212.
ENSMUST00000164119; ENSMUSP00000132519; ENSMUSG00000040212.
GeneIDi13732.
KEGGimmu:13732.
UCSCiuc009gxv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87948 mRNA. Translation: AAC53324.1.
AF011750 mRNA. Translation: AAC33407.1.
AK146939 mRNA. Translation: BAE27548.1.
AC149053 Genomic DNA. No translation available.
BC001999 mRNA. Translation: AAH01999.1.
CCDSiCCDS21270.1.
RefSeqiNP_001139818.1. NM_001146346.1.
NP_034259.2. NM_010129.2.
UniGeneiMm.20829.

3D structure databases

ProteinModelPortaliO35912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037289.

PTM databases

PhosphoSiteiO35912.

Proteomic databases

PaxDbiO35912.
TopDownProteomicsiO35912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038876; ENSMUSP00000037289; ENSMUSG00000040212.
ENSMUST00000164119; ENSMUSP00000132519; ENSMUSG00000040212.
GeneIDi13732.
KEGGimmu:13732.
UCSCiuc009gxv.2. mouse.

Organism-specific databases

CTDi2014.
MGIiMGI:1098729. Emp3.

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiO35912.
OMAiSDLWYNC.
OrthoDBiEOG091G0RF4.
TreeFamiTF330414.

Miscellaneous databases

PROiO35912.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040212.
CleanExiMM_EMP3.
GenevisibleiO35912. MM.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMP3_MOUSE
AccessioniPrimary (citable) accession number: O35912
Secondary accession number(s): O88333, Q3UIF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.