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Protein

Monocarboxylate transporter 4

Gene

Slc16a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • plasma membrane lactate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-210991. Basigin interactions.
R-RNO-433692. Proton-coupled monocarboxylate transport.
R-RNO-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 4
Short name:
MCT 4
Alternative name(s):
Monocarboxylate transporter 3
Short name:
MCT 3
Solute carrier family 16 member 3
Gene namesi
Name:Slc16a3
Synonyms:Mct3, Mct4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620603. Slc16a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1716CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Topological domaini39 – 6123ExtracellularSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 842CytoplasmicSequence analysis
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Topological domaini106 – 1094ExtracellularSequence analysis
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 14919CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 1799ExtracellularSequence analysis
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Topological domaini201 – 23131CytoplasmicSequence analysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence analysisAdd
BLAST
Topological domaini253 – 26715ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Topological domaini289 – 29810CytoplasmicSequence analysis
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Topological domaini320 – 3212ExtracellularSequence analysis
Transmembranei322 – 34221HelicalSequence analysisAdd
BLAST
Topological domaini343 – 35513CytoplasmicSequence analysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Topological domaini377 – 39115ExtracellularSequence analysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence analysisAdd
BLAST
Topological domaini413 – 47159CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 471470Monocarboxylate transporter 4PRO_0000211396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei430 – 4301PhosphoserineBy similarity
Modified residuei466 – 4661PhosphothreonineBy similarity
Modified residuei470 – 4701PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35910.
PRIDEiO35910.

Expressioni

Gene expression databases

ExpressionAtlasiO35910. baseline and differential.
GenevisibleiO35910. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051822.

Structurei

3D structure databases

ProteinModelPortaliO35910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO35910.
KOiK08180.
OMAiASFCRSV.
OrthoDBiEOG7W9RTN.
PhylomeDBiO35910.

Family and domain databases

InterProiIPR004743. MCT.
IPR030756. MCT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF27. PTHR11360:SF27. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM
60 70 80 90 100
HEFGIGYSDT AWISSILLAM LYGTGPLCSM CVNRFGCRPV MLVGGLFASL
110 120 130 140 150
GMVAASFCRS IIQIYLTTGV ITGLGLALNF QPSLIMLNRY FNKRRPMANG
160 170 180 190 200
LAAAGSPVFL CALSPLGQLL QDHYGWRGGF LILGGLLLNC CVCAALMRPL
210 220 230 240 250
VAPQASGGAE PHGPQRPSPR LLDLSVFRDR GFLIYAVAAS IMVLGLFVPP
260 270 280 290 300
VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY
310 320 330 340 350
LFSFAMFFNG FTDLTGSTAS DYGGLVVFCI FFGISYGMVG ALQFEVLMAI
360 370 380 390 400
VGTQKFSSAI GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL
410 420 430 440 450
TSSLVLLLGN FFCIGKRKRP EVTKPEEVAS EEEKLHKPPV DVRVDSREVE
460 470
HFLKAEPEKN GEVVHTPETS V
Length:471
Mass (Da):50,549
Last modified:January 1, 1998 - v1
Checksum:i7EED86F82777527A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87627 mRNA. Translation: AAC53591.1.
RefSeqiNP_110461.1. NM_030834.1.
XP_006247993.1. XM_006247931.2.
XP_006247994.1. XM_006247932.2.
XP_006247995.1. XM_006247933.2.
XP_006247996.1. XM_006247934.2.
XP_008766735.1. XM_008768513.1.
XP_008766736.1. XM_008768514.1.
UniGeneiRn.10826.

Genome annotation databases

EnsembliENSRNOT00000054939; ENSRNOP00000051822; ENSRNOG00000036677.
ENSRNOT00000086096; ENSRNOP00000069286; ENSRNOG00000036677.
GeneIDi80878.
KEGGirno:80878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87627 mRNA. Translation: AAC53591.1.
RefSeqiNP_110461.1. NM_030834.1.
XP_006247993.1. XM_006247931.2.
XP_006247994.1. XM_006247932.2.
XP_006247995.1. XM_006247933.2.
XP_006247996.1. XM_006247934.2.
XP_008766735.1. XM_008768513.1.
XP_008766736.1. XM_008768514.1.
UniGeneiRn.10826.

3D structure databases

ProteinModelPortaliO35910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051822.

Proteomic databases

PaxDbiO35910.
PRIDEiO35910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054939; ENSRNOP00000051822; ENSRNOG00000036677.
ENSRNOT00000086096; ENSRNOP00000069286; ENSRNOG00000036677.
GeneIDi80878.
KEGGirno:80878.

Organism-specific databases

CTDi9123.
RGDi620603. Slc16a3.

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO35910.
KOiK08180.
OMAiASFCRSV.
OrthoDBiEOG7W9RTN.
PhylomeDBiO35910.

Enzyme and pathway databases

ReactomeiR-RNO-210991. Basigin interactions.
R-RNO-433692. Proton-coupled monocarboxylate transport.
R-RNO-70268. Pyruvate metabolism.

Miscellaneous databases

PROiO35910.

Gene expression databases

ExpressionAtlasiO35910. baseline and differential.
GenevisibleiO35910. RN.

Family and domain databases

InterProiIPR004743. MCT.
IPR030756. MCT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF27. PTHR11360:SF27. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3."
    Wilson M.C., Jackson V.N., Heddle C., Price N.T., Pilegaard H., Juel C., Bonen A., Montgomery I., Hutter O.F., Halestrap A.P.
    J. Biol. Chem. 273:15920-15926(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Skeletal muscle.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT4_RAT
AccessioniPrimary (citable) accession number: O35910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.