Reviewed,
UniProtKB/Swiss-Prot O35904 (PK3CD_MOUSE)
Last modified
October 13, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform EC=2.7.1.153 Alternative name(s): PI3-kinase p110 subunit delta PtdIns-3-kinase p110 Short name=PI3K p110delta | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1043 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. |
| Pathway | Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. |
| Subunit structure | Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS. Ref.2 |
| Tissue specificity | Expressed predominantly in leukocytes. |
| Post-translational modification | Autophosphorylation on Ser-1038 results in the almost complete inactivation of the lipid kinase activity By similarity. |
| Sequence similarities | Belongs to the PI3/PI4-kinase family. Contains 1 PI3K/PI4K domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | B cell activation Inferred from mutant phenotype. Source: MGI B cell homeostasisInferred from mutant phenotype. Source: MGI cell surface receptor linked signal transductionInferred from mutant phenotype. Source: MGI phosphoinositide phosphorylationInferred from electronic annotation. Source: InterPro phosphoinositide-mediated signalingInferred from electronic annotation. Source: InterPro |
| Cellular component | phosphoinositide 3-kinase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | 1-phosphatidylinositol-3-kinase activity Inferred from electronic annotation. Source: InterPro ATP bindingInferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-4,5-bisphosphate 3-kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1043 | 1043 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform | PRO_0000088791 | |||||
Regions | |||||||||
| Domain | 775 – 1028 | 254 | PI3K/PI4K | ||||||
Amino acid modifications | |||||||||
| Modified residue | 523 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 1038 | 1 | Phosphoserine; by autocatalysis By similarity | ||||||
Sequences
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References
| [1] | "p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes." Chantry D., Vojtek A., Kashishian A., Holtzman D.A., Wood C., Gray P.W., Cooper J.A., Hoekstra M.F. J. Biol. Chem. 272:19236-19241(1997) [PubMed: 9235916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen. |
| [2] | "Role of Eras in promoting tumor-like properties in mouse embryonic stem cells." Takahashi K., Mitsui K., Yamanaka S. Nature 423:541-545(2003) [PubMed: 12774123] [Abstract] Cited for: INTERACTION WITH ERAS. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U86587 mRNA. Translation: AAC25676.1. | |
| IPI | IPI00885697. |
| PIR | T43502. |
| UniGene | Mm.229108 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1E8Y based on UniProtKB P48736. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O35904. 2 interactions. |
| STRING | O35904. |
PTM databases | |
| PhosphoSite | O35904. |
Proteomic databases | |
| PRIDE | O35904. |
Genome annotation databases | |
| Ensembl | ENSMUST00000105689; ENSMUSP00000101314; ENSMUSG00000039936; Mus musculus. [Genome view] ENSMUST00000105690; ENSMUSP00000101315; ENSMUSG00000039936; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:1098211. Pik3cd. |
Phylogenomic databases | |
| HOVERGEN | O35904. |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.153. 244. |
Gene expression databases | |
| ArrayExpress | O35904. |
| Bgee | O35904. |
| Genevestigator | O35904. |
| GermOnline | ENSMUSG00000039936. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR002420. PI3K_C2. IPR003113. PI3K_p85_bd. IPR000341. PI3K_ras_bd. IPR001263. PI3Ka. IPR015433. PI_Kinase. [Graphical view] |
| Gene3D | G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit. G3DSA:1.25.40.70. PI3Ka. 1 hit. |
| PANTHER | PTHR10048. PI_Kinase. 1 hit. |
| Pfam | PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF02192. PI3K_p85B. 1 hit. PF00794. PI3K_rbd. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view] |
| SMART | SM00142. PI3K_C2. 1 hit. SM00143. PI3K_p85B. 1 hit. SM00144. PI3K_rbd. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view] |
| PROSITE | PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | PK3CD_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O35904 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


